Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Johan Israelian"'
Autor:
Elvin D. de Araujo, Fettah Erdogan, Heidi A. Neubauer, Deniz Meneksedag-Erol, Pimyupa Manaswiyoungkul, Mohammad S. Eram, Hyuk-Soo Seo, Abdul K. Qadree, Johan Israelian, Anna Orlova, Tobias Suske, Ha T. T. Pham, Auke Boersma, Simone Tangermann, Lukas Kenner, Thomas Rülicke, Aiping Dong, Manimekalai Ravichandran, Peter J. Brown, Gerald F. Audette, Sarah Rauscher, Sirano Dhe-Paganon, Richard Moriggl, Patrick T. Gunning
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Hyper-activated STAT5B and its disease-causing variants are of interest as cancer drug targets. Here the authors combine cell based studies, X-ray crystallography, biophysical experiments and MD simulations to structurally and functionally characteri
Externí odkaz:
https://doaj.org/article/f8b672c48f8f4b91911646f53ce84f0b
Autor:
Nabanita Nawar, Shazreh Bukhari, Ashley A. Adile, Yujin Suk, Pimyupa Manaswiyoungkul, Krimo Toutah, Olasunkanmi O. Olaoye, Yasir S. Raouf, Abootaleb Sedighi, Harsimran Kaur Garcha, Muhammad Murtaza Hassan, William Gwynne, Johan Israelian, Tudor B. Radu, Mulu Geletu, Ayah Abdeldayem, Justyna M. Gawel, Aaron D. Cabral, Chitra Venugopal, Elvin D. de Araujo, Sheila K. Singh, Patrick T. Gunning
Publikováno v:
Journal of Medicinal Chemistry. 65:3193-3217
Autor:
Fettah, Erdogan, Tudor Bogdan, Radu, Anna, Orlova, Abdul Khawazak, Qadree, Elvin Dominic, de Araujo, Johan, Israelian, Peter, Valent, Satu M, Mustjoki, Marco, Herling, Richard, Moriggl, Patrick Thomas, Gunning
Publikováno v:
Journal of cellular and molecular medicine. 26(7)
Through a comprehensive review and in silico analysis of reported data on STAT-linked diseases, we analysed the communication pathways and interactome of the seven STATs in major cancer categories and proposed rational targeting approaches for therap
Autor:
Richard Moriggl, Manimekalai Ravichandran, Thomas Rülicke, Lukas Kenner, Peter Brown, Sarah Rauscher, Mohammad S. Eram, Ha T. T. Pham, Fettah Erdogan, Deniz Meneksedag-Erol, Simone Tangermann, Aiping Dong, Auke Boersma, Patrick T. Gunning, Pimyupa Manaswiyoungkul, Elvin D. de Araujo, Hyuk-Soo Seo, Sirano Dhe-Paganon, Abdul K. Qadree, Gerald F. Audette, Johan Israelian, Anna Orlova, Heidi A. Neubauer, Tobias Suske
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5BN642H, a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patient carriers, although the molecular or
Autor:
Andrew E. Shouksmith, Abootaleb Sedighi, Yasir S. Raouf, Niyati Kachhiyapatel, Ayah Abdeldayem, Paris R. Watson, Krimo Toutah, Olasunkanmi O. Olaoye, David W. Christianson, Patrick T. Gunning, Shazreh Bukhari, Pimyupa Manaswiyoungkul, Justyna M. Gawel, Aaron D. Cabral, Johan Israelian, Muhammad Murtaza Hassan, Nabanita Nawar, Fettah Erdogan, Elvin D. de Araujo, Tudor B. Radu, Mulu Geletu
Publikováno v:
J Med Chem
Histone deacetylase 6 (HDAC6) is involved in multiple regulatory processes, ranging from cellular stress to intracellular transport. Inhibition of aberrant HDAC6 activity in several cancers and neurological diseases has been shown to be efficacious i
Autor:
Patrick T. Gunning, Yasir S. Raouf, Muhammad Murtaza Hassan, Jana von Jan, Aleksandr Ianevski, Muzaffar N. Bhatti, Justyna M. Gawel, Mulu Geletu, Pimyupa Manaswiyoungkul, Nabanita Nawar, Elvin D. de Araujo, Helena Sorger, Olasunkanmi O. Olaoye, Tero Aittokallio, Oliver H. Krämer, Marco Herling, Sanna Timonen, Ayah Abdeldayem, Krimo Toutah, Tudor B. Radu, Richard Moriggl, Shazreh Bukhari, Johan Israelian, Heidi A. Neubauer, Satu Mustjoki, Andrew E. Shouksmith, Abootaleb Sedighi
Publikováno v:
Journal of Medicinal Chemistry
Epigenetic targeting has emerged as an efficacious therapy for hematological cancers. The rare and incurable T-cell prolymphocytic leukemia (T-PLL) is known for its aggressive clinical course. Current epigenetic agents such as histone deacetylase (HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3a89d15e76dd9bd052d4a50193efb2
http://hdl.handle.net/10852/93204
http://hdl.handle.net/10852/93204
Autor:
Muhammad Murtaza Hassan, Yasir S. Raouf, Pimyupa Manaswiyoungkul, Aaron D. Cabral, Abootaleb Sedighi, Rabia Altintas, Fettah Erdogan, Patrick T. Gunning, Giovanni Ganda, David W.J. Armstrong, Olasunkanmi O. Olaoye, Elvin D. de Araujo, Johan Israelian, Fabrizio Angeles, Nabanita Nawar
Publikováno v:
Journal of medicinal chemistry. 63(15)
Histone deacetylases (HDACs) are an attractive therapeutic target for a variety of human diseases. Currently, all four FDA-approved HDAC-targeting drugs are nonselective, pan-HDAC inhibitors, exhibiting adverse side effects at therapeutic doses. Alth
Autor:
Abootaleb Sedighi, Yasir S. Raouf, Diana Sina, Krimo Toutah, Johan Israelian, Andrew E. Shouksmith, Patrick T. Gunning, Shazreh Bukhari, Elvin D. de Araujo, Olasunkanmi O. Olaoye, Aaron D. Cabral, Nabanita Nawar, Tudor B. Radu, Justyna M. Gawel, Pimyupa Manaswiyoungkul
Publikováno v:
European journal of medicinal chemistry. 201
Dysregulated Histone Deacetylase (HDAC) activity across multiple human pathologies have highlighted this family of epigenetic enzymes as critical druggable targets, amenable to small molecule intervention. While efficacious, current approaches using
Autor:
Shiva Farhangi, Elvin D. de Araujo, Ji Sung Park, Angelika Berger-Becvar, Patrick T. Gunning, Pimyupa Manaswiyoungkul, Karen Yuen, Lubna Abu-Jazar, Johan Israelian
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 143:159-167
The development of STAT protein-specific inhibitors has been the focus of a number of drug discovery programs. STAT activation occurs through phosphorylation at the STAT SH2 domain, resulting in dimerization, translocation to the nucleus, and transcr
Autor:
Alp Sipahigil, Young-Ik Sohn, Michael J. Burek, Mikhail D. Lukin, Srujan Meesala, Ruffin E. Evans, Nigel J. Clarke, Adarsh S. Patri, Marko Loncar, Robert M. Westervelt, Denis D. Sukachev, Johan Israelian, Haig A. Atikian
Publikováno v:
SPIE Newsroom.