Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Johan Holmkvist"'
Autor:
Camilla Noelle Rathcke, Johan Holmkvist, Lise Lotte N Husmoen, Torben Hansen, Oluf Pedersen, Henrik Vestergaard, Allan Linneberg
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6106 (2009)
YKL-40 is a chitinase-like glycoprotein encoded by the chitinase 3-like 1 gene, CHI3L1, localized at chromosome 1q32.1. Increased levels of serum YKL-40 have been reported to be a biomarker for asthma and a reduced lung function. Interestingly, the C
Externí odkaz:
https://doaj.org/article/8645bc7b7160486193f89ef6185df85d
Autor:
Johan Holmkvist, Karina Banasik, Gitte Andersen, Hiroyuki Unoki, Thomas Skot Jensen, Charlotta Pisinger, Knut Borch-Johnsen, Annelli Sandbaek, Torsten Lauritzen, Sören Brunak, Shiro Maeda, Torben Hansen, Oluf Pedersen
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5872 (2009)
BackgroundPolymorphisms in the potassium channel, voltage-gated, KQT-like subfamily, member 1 (KCNQ1) have recently been reported to associate with type 2 diabetes. The primary aim of the present study was to investigate the putative impact of these
Externí odkaz:
https://doaj.org/article/0d58a0cd81f841f78d30959a06c09843
Autor:
Camilla Noelle Rathcke, Johan Holmkvist, Torben Jørgensen, Knut Borch-Johnsen, Torben Hansen, Oluf Borbye Pedersen, Henrik Vestergaard
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5469 (2009)
CHI3LI encoding the inflammatory glycoprotein YKL-40 is located on chromosome 1q32.1. YKL-40 is involved in inflammatory processes and patients with Type 2 Diabetes (T2D) have elevated circulating YKL-40 levels which correlate with their level of ins
Externí odkaz:
https://doaj.org/article/0a8548da709f41ff8d9c1bc47bedd5b0
Autor:
M. Tang, S. Y. Kim, Tom Forsén, Yun Li, Q. Li, Karina Banasik, J. M. Dekker, Leif Groop, B. Balkau, N. van Leeuwen, Jacek Mokrosinski, G. Tian, Alex S. F. Doney, Thue W. Schwartz, H. Jiang, Johanna Kuusisto, Thorfinn Sand Korneliussen, S. Huang, Guillaume Charpentier, Giel Nijpels, Daniel R. Witte, Maria Lajer, Alena Stančáková, F. Xi, Oluf Pedersen, Anders Albrechtsen, Torben Jørgensen, Mozhgan Dorkhan, Torben Hansen, Amanda J. Bennett, B. Wang, Gregers S. Andersen, Chang Yu, Aneta Aleksandra Nielsen, Mark I. McCarthy, Lise Tarnow, Markku Laakso, Timothy M. Frayling, P.E. Slagboom, Olov Rolandsson, Y. Wang, Torsten Lauritzen, Christopher J. Groves, Weihua Zhang, Peter M. Nilsson, T. Jiang, Loic Yengo, Leen M 't Hart, Y. Gui, Tiinamaija Tuomi, Chao Nie, Peter Rossing, J. Zhang, Frida Renström, Andrew D. Morris, Cramer Christensen, Graham A. Hitman, Neil Robertson, H. Cao, Göran Hallmans, Allan Linneberg, Niels Grarup, Line Skotte, H. Wu, Colin N. A. Palmer, M. P. Manijak, Q. Zhang, Andrew P. Morris, Rasmus Ribel-Madsen, Yi Chen, Arne Astrup, Tibor V. Varga, Mark Walker, Y. Zhou, Jun Wang, Maria Sterner, Paul W. Franks, Lars Bolund, Andrew T. Hattersley, Johan Holmkvist, Karsten Kristiansen, David Altshuler, E. van 't Riet, Philippe Froguel, Stéphane Cauchi, R. Wu, Kunlun He, B. Mu, X. Ma, X. Liu, Weijing Li, H. Liang, Rasmus Nielsen, Olivier Lantieri, T. Ma, Xin Jin, Claes Ladenvall, Michel Marre, Nigel W. Rayner, Thomas Sparsø, Marie A. Vestmar, Johanne Marie Justesen, Ivan Brandslund, Q. Liao, Xiaoming Zhang, H. Zheng
Publikováno v:
Diabetologia
Diabetologia, 56(2), 298-310. Springer Verlag
Albrechtsen, A, Grarup, N, Li, Y, Sparsø, T H, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T S, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stancáková, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Liu, X, Ma, T, Ma, X, Manijak, M P, Marre, M, Mokrosinski, J, Morris, A D, Mu, B, Nielsen, A A, Nijpels, G, Nilsson, P, Palmer, C N A, Rayner, N W, Renström, F, Ribel-Madsen, R, Robertson, N, Rolandsson, O, Rossing, P, Schwartz, T W, Slagboom, P E, Sterner, M, Tang, M, Tarnow, L, Tuomi, T, Van't Riet, E, van Leeuwen, N, Varga, T V, Vestmar, M A, Walker, M, Wang, B, Wang, Y, Wu, H, Xi, F, Yengo, L, Yu, C, Zhang, X, Zhang, J, Zhang, Q, Zhang, W, Zheng, H, Zhou, Y, Altshuler, D, 't Hart, L M, Franks, P W, Balkau, B, Froguel, P, McCarthy, M I, Laakso, M, Groop, L, Christensen, C, Brandslund, I, Lauritzen, T, Witte, D R, Linneberg, A, Jørgensen, T, Hansen, T, Wang, J, Nielsen, R & Pedersen, O 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
Albrechtsen, A, Grarup, N, Li, Y, Sparsø, T H, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stančáková, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Nielsen, A A, Christensen, C, Brandslund, I & D.E.S.I.R. Study Group 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
Albrechtsen, A, Grarup, N, Li, Y, Sparso, T, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stancakova, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Liu, X, Ma, T, Ma, X, Manijak, M P, Marre, M, Mokrosinski, J, Morris, A D, Mu, B, Nielsen, A A, Nijpels, G, Nilsson, P, Palmer, C N A, Rayner, N W, Renström, F, Ribel-Madsen, R, Robertson, N, Rolandsson, O, Rossing, P, Schwartz, T W, Slagboom, P E, Sterner, M, Tang, M, Tarnow, L, Tuomi, T, van't Riet, E, van Leeuwen, N, Varga, T V, Vestmar, M A, Walker, M, Wang, B, Wang, Y, Wu, H, Xi, F, Yengo, L, Yu, C, Zhang, X, Zhang, J, Zhang, Q, Zhang, W, Zheng, H, Zhou, Y, Altshuler, D, 't Hart, L M, Franks, P W, Balkau, B, Froguel, P, McCarthy, M I, Laakso, M, Groop, L, Christensen, C, Brandslund, I, Lauritzen, T, Witte, D R, Linneberg, A, Jørgensen, T, Hansen, T, Wang, J, Nielsen, R & Pedersen, O 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
Diabetologia; Vol 56
Diabetologia, 56(2), 298-310. SPRINGER
Albrechtsen, A, Grarup, N, Li, Y, Sparsø, T H, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T S, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stančáková, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Liu, X, Lauritzen, T, Pedersen, O & D.E.S.I.R. Study Group 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
PMC
Albrechtsen, A, Grarup, N, Li, Y, Sparso, T, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stancakova, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Liu, X, Ma, T, Ma, X, Manijak, M P, Marre, M, Mokrosinski, J, Morris, A D, Mu, B, Nielsen, A A, Nijpels, G, Nilsson, P, Palmer, C N A, Rayner, N W, Renstrom, F, Ribel-Madsen, R, Robertson, N, Rolandsson, O, Rossing, P, Schwartz, T W, Slagboom, P E, Sterner, M, Tang, M, Tarnow, L, Tuomi, T, van 't Riet, E, van Leeuwen, N, Varga, T V, Vestmar, M A, Walker, M, Wang, B, Wang, Y, Wu, H, Xi, F, Yengo, L, Yu, C, Zhang, X, Zhang, J, Zhang, Q, Zhang, W, Zheng, H, Zhou, Y, Altshuler, D, 't Hart, L M, Franks, P W, Balkau, B, Froguel, P, McCarthy, M I, Laakso, M, Groop, L, Christensen, C, Brandslund, I, Lauritzen, T, Witte, D R, Linneberg, A, Jorgensen, T, Hansen, T, Wang, J, Nielsen, R & Pedersen, O 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
Diabetologia, 56(2), 298-310
Diabetologia, 56(2), 298-310. Springer Verlag
Albrechtsen, A, Grarup, N, Li, Y, Sparsø, T H, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T S, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stancáková, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Liu, X, Ma, T, Ma, X, Manijak, M P, Marre, M, Mokrosinski, J, Morris, A D, Mu, B, Nielsen, A A, Nijpels, G, Nilsson, P, Palmer, C N A, Rayner, N W, Renström, F, Ribel-Madsen, R, Robertson, N, Rolandsson, O, Rossing, P, Schwartz, T W, Slagboom, P E, Sterner, M, Tang, M, Tarnow, L, Tuomi, T, Van't Riet, E, van Leeuwen, N, Varga, T V, Vestmar, M A, Walker, M, Wang, B, Wang, Y, Wu, H, Xi, F, Yengo, L, Yu, C, Zhang, X, Zhang, J, Zhang, Q, Zhang, W, Zheng, H, Zhou, Y, Altshuler, D, 't Hart, L M, Franks, P W, Balkau, B, Froguel, P, McCarthy, M I, Laakso, M, Groop, L, Christensen, C, Brandslund, I, Lauritzen, T, Witte, D R, Linneberg, A, Jørgensen, T, Hansen, T, Wang, J, Nielsen, R & Pedersen, O 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
Albrechtsen, A, Grarup, N, Li, Y, Sparsø, T H, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stančáková, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Nielsen, A A, Christensen, C, Brandslund, I & D.E.S.I.R. Study Group 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
Albrechtsen, A, Grarup, N, Li, Y, Sparso, T, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stancakova, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Liu, X, Ma, T, Ma, X, Manijak, M P, Marre, M, Mokrosinski, J, Morris, A D, Mu, B, Nielsen, A A, Nijpels, G, Nilsson, P, Palmer, C N A, Rayner, N W, Renström, F, Ribel-Madsen, R, Robertson, N, Rolandsson, O, Rossing, P, Schwartz, T W, Slagboom, P E, Sterner, M, Tang, M, Tarnow, L, Tuomi, T, van't Riet, E, van Leeuwen, N, Varga, T V, Vestmar, M A, Walker, M, Wang, B, Wang, Y, Wu, H, Xi, F, Yengo, L, Yu, C, Zhang, X, Zhang, J, Zhang, Q, Zhang, W, Zheng, H, Zhou, Y, Altshuler, D, 't Hart, L M, Franks, P W, Balkau, B, Froguel, P, McCarthy, M I, Laakso, M, Groop, L, Christensen, C, Brandslund, I, Lauritzen, T, Witte, D R, Linneberg, A, Jørgensen, T, Hansen, T, Wang, J, Nielsen, R & Pedersen, O 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
Diabetologia; Vol 56
Diabetologia, 56(2), 298-310. SPRINGER
Albrechtsen, A, Grarup, N, Li, Y, Sparsø, T H, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T S, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stančáková, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Liu, X, Lauritzen, T, Pedersen, O & D.E.S.I.R. Study Group 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
PMC
Albrechtsen, A, Grarup, N, Li, Y, Sparso, T, Tian, G, Cao, H, Jiang, T, Kim, S Y, Korneliussen, T, Li, Q, Nie, C, Wu, R, Skotte, L, Morris, A P, Ladenvall, C, Cauchi, S, Stancakova, A, Andersen, G, Astrup, A, Banasik, K, Bennett, A J, Bolund, L, Charpentier, G, Chen, Y, Dekker, J M, Doney, A S F, Dorkhan, M, Forsen, T, Frayling, T M, Groves, C J, Gui, Y, Hallmans, G, Hattersley, A T, He, K, Hitman, G A, Holmkvist, J, Huang, S, Jiang, H, Jin, X, Justesen, J M, Kristiansen, K, Kuusisto, J, Lajer, M, Lantieri, O, Li, W, Liang, H, Liao, Q, Liu, X, Ma, T, Ma, X, Manijak, M P, Marre, M, Mokrosinski, J, Morris, A D, Mu, B, Nielsen, A A, Nijpels, G, Nilsson, P, Palmer, C N A, Rayner, N W, Renstrom, F, Ribel-Madsen, R, Robertson, N, Rolandsson, O, Rossing, P, Schwartz, T W, Slagboom, P E, Sterner, M, Tang, M, Tarnow, L, Tuomi, T, van 't Riet, E, van Leeuwen, N, Varga, T V, Vestmar, M A, Walker, M, Wang, B, Wang, Y, Wu, H, Xi, F, Yengo, L, Yu, C, Zhang, X, Zhang, J, Zhang, Q, Zhang, W, Zheng, H, Zhou, Y, Altshuler, D, 't Hart, L M, Franks, P W, Balkau, B, Froguel, P, McCarthy, M I, Laakso, M, Groop, L, Christensen, C, Brandslund, I, Lauritzen, T, Witte, D R, Linneberg, A, Jorgensen, T, Hansen, T, Wang, J, Nielsen, R & Pedersen, O 2013, ' Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes ', Diabetologia, vol. 56, no. 2, pp. 298-310 . https://doi.org/10.1007/s00125-012-2756-1
Diabetologia, 56(2), 298-310
Aims/hypothesis Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with common metabolic phenoty
Autor:
Göran Berglund, Peter Almgren, B Isomaa, Erik Renström, Valeriya Lyssenko, Leif Groop, Damon Tojjar, Tiinamaija Tuomi, Johan Holmkvist, Cecilia M. Lindgren
AIMS/HYPOTHESIS: Glucose-stimulated insulin secretion is dependent on the electrical activity of beta cells; hence, genes encoding beta cell ion channels are potential candidate genes for type 2 diabetes. The gene encoding the voltage-dependent Ca(2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e8ffa77e765e074e22f4a5992aca90
https://doi.org/10.1007/s00125-007-0846-2
https://doi.org/10.1007/s00125-007-0846-2
Autor:
Torben Hansen, Yingrui Li, Oluf Pedersen, Su Yeon Kim, Rasmus Nielsen, Ruiqiang Li, Yiran Guo, Jun Wang, Johan Holmkvist
Publikováno v:
Kim, S Y, Li, Y, Guo, Y, Li, R, Holmkvist, J, Hansen, T, Pedersen, O, Wang, J & Nielsen, R 2010, ' Design of association studies with pooled or un-pooled next-generation sequencing data ', Genetic Epidemiology, vol. 34, no. 5, pp. 479-91 . https://doi.org/10.1002/gepi.20501
Most common hereditary diseases in humans are complex and multifactorial. Large scale genome-wide association studies based on SNP genotyping, have only identified a small fraction of the heritable variation of these diseases. One explanation may be
Autor:
Torben Jørgensen, A. Sandbaek, Torben Hansen, Camilla H. Andreasen, Thomas Sparsø, Sten Madsbad, Torsten Lauritzen, Knut Borch-Johnsen, Gregers S. Andersen, Johan Holmkvist, Oluf Pedersen, Anders Albrechtsen, Niels Grarup
Publikováno v:
Sparsø, T, Grarup, N, Andreasen, C, Albrechtsen, A, Holmkvist, J, Andersen, G, Jørgensen, T, Borch-Johnsen, K, Sandbaek, A, Lauritzen, T, Madsbad, S, Hansen, T & Pedersen, O 2009, ' Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction ', Diabetologia, vol. 52, no. 7, pp. 1308-14 . https://doi.org/10.1007/s00125-009-1362-3
Udgivelsesdato: 2009-Jul AIMS/HYPOTHESIS: The list of validated type 2 diabetes susceptibility variants has recently been expanded from three to 19. The variants identified are common and have low penetrance in the general population. The aim of the
Autor:
Knut Borch-Johnsen, Claire Levy-Marchal, Amélie Bonnefond, Guillaume Charpentier, Allan Vaag, Marjo-Riitta Järvelin, Karina Banasik, Marion Marchand, Oluf Pedersen, Lise Wegner, Ehm A. Andersson, Niels Grarup, Torben Hansen, Martine Vaxillaire, Anette P. Gjesing, Beverley Balkau, Nabila Bouatia-Naji, Sten Madsbad, Kristine Færch, Christian Dina, Thomas Sparsø, Christine Cavalcanti-Proença, Torben Jørgensen, Michel Marre, Philippe Froguel, Jean Tichet, Pernille Poulsen, Johan Holmkvist
Publikováno v:
Diabetes. 58:1450-1456
OBJECTIVE Genome-wide association studies have identified several variants within the MTNR1B locus that are associated with fasting plasma glucose (FPG) and type 2 diabetes. We refined the association signal by direct genotyping and examined for asso
Autor:
Jean-Claude Chèvre, Jacques Weill, Claire Levy-Marchal, Barbara Heude, Torben Hansen, Katleen Lemaire, Paul Elliott, Marion Marchand, Stéphane Lobbens, Christian Dina, Philippe Froguel, Oluf Pedersen, Jérôme Delplanque, Ghislain Rocheleau, Andrew Walley, Torben Jørgensen, Jean Tichet, Aimo Ruokonen, Knut Borch-Johnsen, Thomas Sparsø, François Pattou, Robert Sladek, Christine Cavalcanti-Proença, Sophie Visvikis-Siest, Alexandra I. F. Blakemore, M. R. Järvelin, Amélie Bonnefond, Maithé Tauber, Michel Marre, Anna-Liisa Hartikainen, Emmanuelle Durand, Beverley Balkau, Frans Schuit, Johan Holmkvist, Stéphane Cauchi, Nabila Bouatia-Naji, Samy Hadjadj, Guillaume Charpentier, Franck De Graeve, David Meyre, Martine Vaxillaire
Publikováno v:
Bouatia-Naji, N, Bonnefond, A, Cavalcanti-Proença, C, Sparsø, T, Holmkvist, J, Marchand, M, Delplanque, J, Lobbens, S, Rocheleau, G, Durand, E, De Graeve, F, Chèvre, J-C, Borch-Johnsen, K, Hartikainen, A-L, Ruokonen, A, Tichet, J, Marre, M, Weill, J, Heude, B, Tauber, M, Lemaire, K, Schuit, F, Elliott, P, Jørgensen, T, Charpentier, G, Hadjadj, S, Cauchi, S, Vaxillaire, M, Sladek, R, Visvikis-Siest, S, Balkau, B, Lévy-Marchal, C, Pattou, F, Meyre, D, Blakemore, A I F, Jarvelin, M-R, Walley, A J, Hansen, T, Dina, C, Pedersen, O & Froguel, P 2009, ' A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk ', Nature Genetics, vol. 41, no. 1, pp. 89-94 . https://doi.org/10.1038/ng.277
Nature Genetics, 41(1), 89-94. Nature Publishing Group
Nature Genetics, 41(1), 89-94. Nature Publishing Group
In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populatio
Autor:
Torben Hansen, Michiaki Kubo, Annelli Sandbæk, Knut Borch-Johnsen, Shiro Maeda, Oluf Pedersen, Tatsuhiko Tsunoda, Torben Jørgensen, Daniel P.K. Ng, Johan Holmkvist, Tetsuya Babazono, Hiroyuki Unoki, Naoyuki Kamatani, Yasuhiko Iwamoto, Hiroshi Hirose, Momoko Horikoshi, Gitte Andersen, Siti Nurbaya, Atsushi Takahashi, Takahisa Kawaguchi, Torsten Lauritzen, Ryuichi Kikkawa, Yusuke Nakamura, Atsunori Kashiwagi, Kazuo Hara, Matsuhiko Hayashi, Takashi Kadowaki, Ryuzo Kawamori, Kohei Kaku, E. Shyong Tai
Publikováno v:
Unoki, H, Takahashi, A, Kawaguchi, T, Hara, K, Horikoshi, M, Ng, D P K, Holmkvist, J, Borch-Johnsen, K, Jørgensen, T, Sandbaek, A, Lauritzen, T, Hansen, T, Nurbaya, S, Tsunoda, T, Kubo, M, Babazono, T, Hirose, H, Hayashi, M, Iwamoto, Y, Kashiwagi, A, Kaku, K, Kawamori, R, Tai, E S, Pedersen, O, Kamatani, N, Kadowaki, T, Kikkawa, R, Nakamura, Y & Maeda, S 2008, ' SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations ', Nature Genetics, vol. 40, no. 9, pp. 1098-102 . https://doi.org/10.1038/ng.208
Udgivelsesdato: 2008-Sep We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1)