Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Johan Hellsten"'
Autor:
Daniel Oudin Åström, Jacob Simonsen, Lars Lau Raket, Simona Sgarbi, Johan Hellsten, Peter Hagell, Jenny M. Norlin, Klas Kellerborg, Pablo Martinez-Martin, Per Odin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Dementia have substantial negative impact on the affected individual, their care partners and society. Persons living with Parkinson’s disease (PwP) are also to a large extent living with dementia. The aim of this study is to estimate time
Externí odkaz:
https://doaj.org/article/8d6d648fa4dd4c35b873a165703e742d
Autor:
Jennifer R. Mammen, Rebecca M. Speck, Glenn M. Stebbins, Martijn L.T.M. Müller, Phillip T. Yang, Michelle Campbell, Josh Cosman, John E. Crawford, Tien Dam, Johan Hellsten, Stella Jensen-Roberts, Melissa Kostrzebski, Tanya Simuni, Kimberly Ward Barowicz, Jesse M. Cedarbaum, E. Ray Dorsey, Diane Stephenson, Jamie L. Adams
Publikováno v:
Journal of Parkinson's Disease. :1-19
Background: Adoption of new digital measures for clinical trials and practice has been hindered by lack of actionable qualitative data demonstrating relevance of these metrics to people with Parkinson’s disease. Objective: This study evaluated of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f285741d0adad4c0928eab28e4a3110a
https://doi.org/10.3233/jpd-225122
https://doi.org/10.3233/jpd-225122
Autor:
Jennifer R. Mammen, Rebecca M. Speck, Glenn T. Stebbins, Martijn L.T.M. Müller, Phillip T. Yang, Michelle Campbell, Josh Cosman, John E. Crawford, Tien Dam, Johan Hellsten, Stella Jensen-Roberts, Melissa Kostrzebski, Tanya Simuni, Kimberly Ward Barowicz, Jesse M. Cedarbaum, E. Ray Dorsey, Diane Stephenson, Jamie L. Adams
Publikováno v:
Journal of Parkinson's Disease. :1-14
Background: Patient perspectives on meaningful symptoms and impacts in early Parkinson’s disease (PD) are lacking and are urgently needed to clarify priority areas for monitoring, management, and new therapies. Objective: To examine experiences of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a28086207e73b466ee61a6cdd5c6efd
https://doi.org/10.3233/jpd-225068
https://doi.org/10.3233/jpd-225068
Autor:
Johan Hellsten, Denise Chang, Gary S. Sachs, Claudette Brewer, Timothy Peters-Strickland, Nanco Hefting, Eduard Vieta
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
Background: Brexpiprazole is a dopamine/serotonin receptor partial agonist (D2, 5-HT1A) and antagonist (5-HT2A) approved for treatment of schizophrenia and major depressive disorder (adjunct to antidepressants). Aims: This study aimed to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a21dec3ff3167f59b18c76c5656ef38
http://europepmc.org/articles/PMC8366183
http://europepmc.org/articles/PMC8366183
Autor:
Ugne Sabaliauskaite, Anne Vinther Morant, Anders Blaedel Lassen, Johan Hellsten, Katrine Schultz-Knudsen
Publikováno v:
Therapeutic Innovation & Regulatory Science
Background The FDA Patient-Focused Drug Development Initiative was launched to ensure the incorporation of the patient voice into drug development and evaluation. Since 2017, the FDA must publish a statement outlining patient experience data (PED) co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17c96b8955e74481d427bd756dc607d
https://doi.org/10.1007/s43441-020-00244-x
https://doi.org/10.1007/s43441-020-00244-x
Publikováno v:
Biological Psychiatry. 54:1015-1024
Analysis of postmortem tissue from patients with major depression and bipolar disorder has revealed structural changes in several brain regions. We have shown that electroconvulsive seizure (ECS), used for the treatment of severe depression, induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b226fca310108fae3b317de405eee1
https://doi.org/10.1016/s0006-3223(03)00693-0
https://doi.org/10.1016/s0006-3223(03)00693-0
Autor:
Paul Mohapel, Anders Tingström, Johan Hellsten, Malin Wennström, Christine T. Ekdahl, Johan Bengzon
Publikováno v:
European Journal of Neuroscience. 16:283-290
Major depression is often associated with elevated glucocorticoid levels. High levels of glucocorticoids reduce neurogenesis in the adult rat hippocampus. Electroconvulsive seizures (ECS) can enhance neurogenesis, and we investigated the effects of E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72624358700877516d535851eadf63f6
https://doi.org/10.1046/j.1460-9568.2002.02093.x
https://doi.org/10.1046/j.1460-9568.2002.02093.x
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 32(6)
Antidepressant drugs and electroconvulsive seizure (ECS)-treatment, an animal model of electroconvulsive therapy, induce neurogenesis in adult rats. Stress and high levels of corticosterone (CORT) on the contrary inhibit neurogenesis. Hippocampal neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227bdf0bb43e2daaf88128402db942ab
https://pubmed.ncbi.nlm.nih.gov/18583010
https://pubmed.ncbi.nlm.nih.gov/18583010
Publikováno v:
Neuroscience letters. 442(3)
Stress and environmental enrichment have opposing effects on cerebral cellular plasticity. Stress-induced disturbances in neuronal and glial plasticity have been implicated in the pathophysiology of affective disorders. Patients with depression often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e64c413694ba7bae675f41f0119769
https://pubmed.ncbi.nlm.nih.gov/18625288
https://pubmed.ncbi.nlm.nih.gov/18625288
Publikováno v:
Biological Psychiatry; 59(2), pp 178-186 (2006)
Background: Volumetric changes and glial pathology have been reported in the central nervous system (CNS) of patients with depressive disorder, an illness often associated with elevated glucocorticoid levels. Glucocorticoids reduce gliogenesis in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d0ceaf89a801e37576a99f6a8f6554
http://lup.lub.lu.se/record/150169
http://lup.lub.lu.se/record/150169
