Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Johan Hekelaar"'
Autor:
Francisca Monteiro, Georg Hubmann, Vakil Takhaveev, Silke R Vedelaar, Justin Norder, Johan Hekelaar, Joana Saldida, Athanasios Litsios, Hein J Wijma, Alexander Schmidt, Matthias Heinemann
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 12, Pp 1-20 (2019)
Abstract Metabolic heterogeneity between individual cells of a population harbors significant challenges for fundamental and applied research. Identifying metabolic heterogeneity and investigating its emergence require tools to zoom into metabolism o
Externí odkaz:
https://doaj.org/article/4e0eb7e0221f4bcc8a9bb0a80a89742a
Publikováno v:
Journal of the American Chemical Society, 144(8), 3644-3652. AMER CHEMICAL SOC
Macrocyclic peptides (MPs) have positioned themselves as a privileged class of compounds for the discovery of therapeutics and development of chemical probes. Aided by the development of powerful selection strategies, high-affinity binders against bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2464488e19911a58981657ac20a778b
https://doi.org/10.1021/jacs.1c12822
https://doi.org/10.1021/jacs.1c12822
Autor:
Nittert Marinus, Adriaan Minnaard, Liubov Yakovlieva, Johan Hekelaar, Martin Witte, Francesca Nuti, Marthe Walvoort, Anna Maria Papini, Niels Reintjens
Publikováno v:
European Journal of Organic Chemistry, 2022(25):e202200677. WILEY-V C H VERLAG GMBH
Selective modification of carbohydrate residues in glycopeptides is highly relevant as a tool in glycobiology. In particular, oxidation allows for subsequent ligation with a label or handle and can be effectuated enzymatically or chemically. Chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff9015a4a9380fca09e90cef51bf955
https://research.rug.nl/en/publications/79858465-10c9-44cd-b08b-960a035ec9a7
https://research.rug.nl/en/publications/79858465-10c9-44cd-b08b-960a035ec9a7
Autor:
Marthe Walvoort, Adriaan J. Minnaard, Martin D. Witte, Anna Maria Papini, Francesca Nuti, Johan Hekelaar, Nittert Marinus, Liubov Yakovlieva, Niels R.M. Reintjens
Here we report a novel method of site-selective oxidation of glucose moieties on individual glycopeptides and on a mixture of tryptic glycopeptides. The organometallic catalyst [(neocuproine)PdOAc]2OTf2, that was previously shown to perform regiosele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a89915684875bb8e8d1e37b0e8898c1d
https://doi.org/10.26434/chemrxiv.14230244
https://doi.org/10.26434/chemrxiv.14230244
The cyclization of peptides appended onto proteins or whole bacteriophages is typically achieved via disulfide formation, the use of symmetric crosslinkers or the incorporation of noncanonical amino acids. Unfortunately, neither of these strategies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7641647c50e769b296da8a2b4312ccdb
https://doi.org/10.26434/chemrxiv.13705618
https://doi.org/10.26434/chemrxiv.13705618
Autor:
Justin Norder, Athanasios Litsios, Georg Hubmann, Alexander Schmidt, Francisca Monteiro, Hein J. Wijma, Vakil Takhaveev, Joana Saldida, Johan Hekelaar, Matthias Heinemann, Silke R Vedelaar
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 12, Pp n/a-n/a (2019)
Molecular Systems Biology, 15(12):e9071. Wiley-Blackwell
Molecular Systems Biology
Molecular Systems Biology, 15(12):e9071. Wiley-Blackwell
Molecular Systems Biology
Metabolic heterogeneity between individual cells of a population harbors significant challenges for fundamental and applied research. Identifying metabolic heterogeneity and investigating its emergence require tools to zoom into metabolism of individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7c36fdcc9be093e65556d7ca234a99
https://hdl.handle.net/11370/5dda4deb-1257-456c-b125-641edf70059e
https://hdl.handle.net/11370/5dda4deb-1257-456c-b125-641edf70059e
Autor:
Alexandros Papagiannakis, Georg Hubmann, Mattia Rovetta, Paolo Guerra, Matthias Heinemann, Alexander Schmidt, Marten Exterkate, Katarzyna Buczak, Johan Hekelaar, Daphne H. E. W. Huberts, Hanna M Terpstra, Andreas Milias-Argeitis, Athanasios Litsios
Publikováno v:
Nature Cell Biology, 21(11), 1382-1392. Nature Publishing Group
In the unicellular eukaryote Saccharomyces cerevisiae, Cln3-cyclin-dependent kinase activity enables Start, the irreversible commitment to the cell division cycle. However, the concentration of Cln3 has been paradoxically considered to remain constan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253082fcd877cc033181b0405cb1507d
https://research.rug.nl/en/publications/f62a7640-f7c6-4558-b5ef-3e8daf78810f
https://research.rug.nl/en/publications/f62a7640-f7c6-4558-b5ef-3e8daf78810f
Autor:
Athanasios Litsios, Justin Norder, Hein J. Wijma, Joana Saldida, Georg Hubmann, Alexander Schmidt, Matthias Heinemann, Johan Hekelaar, Francisca Monteiro
Metabolic heterogeneity between individual cells of a population harbors offers significant challenges for fundamental and applied research. Identifying metabolic heterogeneity and investigating its emergence requires tools to zoom into metabolism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907ab65c17a3778ae8474d55e3a8a442
https://doi.org/10.1101/682302
https://doi.org/10.1101/682302
Autor:
Niels van Oosterwijk, Simon C. Willies, Johan Hekelaar, Nicholas J. Turner, Bauke W. Dijkstra, Anke C. Terwisscha van Scheltinga
Publikováno v:
Biochemistry, 55(31), 4422-4431. AMER CHEMICAL SOC
ω-Transaminases are enzymes that can introduce an amino group in industrially interesting compounds. We determined crystal structures of two (S)-selective ω-transaminases, one from Arthrobacter sp. (Ars-ωTA) and one from Bacillus megaterium (BM-ω
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6458858c0a0e329bc0a2fd3d5228f0
https://hdl.handle.net/11370/6b7d2794-e275-4669-b57b-1b7c12eaa4a9
https://hdl.handle.net/11370/6b7d2794-e275-4669-b57b-1b7c12eaa4a9
Autor:
Tiziana Masini, Simon van Dijk, Edelmiro Moman, Barbara Birkaya, Milon Mondal, Manuel Jäger, Mulchand S. Patel, Anna K. H. Hirsch, Anke C. Terwisscha van Scheltinga, Johan Hekelaar
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry, 31 (S4), 170-175. TAYLOR & FRANCIS LTD
The last decade has witnessed the reawakening of cancer metabolism as a therapeutic target. In particular, inhibition of pyruvate dehydrogenase kinase (PDK) holds remarkable promise. Dichloroacetic acid (DCA), currently undergoing clinical trials, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad7fb0895344455358d81da91c065b9
https://doi.org/10.1080/14756366.2016.1201812
https://doi.org/10.1080/14756366.2016.1201812