Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Johan Hartman"'
Autor:
Abhinav Sharma, Sandy Kang Lövgren, Kajsa Ledesma Eriksson, Yinxi Wang, Stephanie Robertson, Johan Hartman, Mattias Rantalainen
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Background Stratipath Breast is a CE-IVD marked artificial intelligence-based solution for prognostic risk stratification of breast cancer patients into high- and low-risk groups, using haematoxylin and eosin (H&E)-stained histopathology who
Externí odkaz:
https://doaj.org/article/efc316e62709488f9a054523aa5c9212
Autor:
Dimitrios Salgkamis, Emmanouil G. Sifakis, Susanne Agartz, Valtteri Wirta, Johan Hartman, Jonas Bergh, Theodoros Foukakis, Alexios Matikas, Ioannis Zerdes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Formalin-fixed paraffin-embedded (FFPE) tissue represents a valuable source for translational cancer research. However, the widespread application of various downstream methods remains challenging. Here, we aimed to assess the feasibility of
Externí odkaz:
https://doaj.org/article/e736a762e4b949bdab0947513514842e
Autor:
Ilke Demirci, Anton J. M. Larsson, Xinsong Chen, Johan Hartman, Rickard Sandberg, Jonas Frisén
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Analysis of clonal dynamics in human tissues is enabled by somatic genetic variation. Here, we show that analysis of mitochondrial mutations in single cells is dramatically improved in females when using X chromosome inactivation to select i
Externí odkaz:
https://doaj.org/article/6cf0e14ba5474cb585cef9c5ef1292f1
Autor:
Constance Boissin, Yinxi Wang, Abhinav Sharma, Philippe Weitz, Emelie Karlsson, Stephanie Robertson, Johan Hartman, Mattias Rantalainen
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-11 (2024)
Abstract Background Nottingham histological grade (NHG) is a well established prognostic factor in breast cancer histopathology but has a high inter-assessor variability with many tumours being classified as intermediate grade, NHG2. Here, we evaluat
Externí odkaz:
https://doaj.org/article/5004d7a2138a48d19864c4ecb1580cfe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Around 75% of breast cancer (BC) patients have tumors expressing the predictive biomarker estrogen receptor α (ER) and are offered endocrine therapy. One-third eventually develop endocrine resistance, a majority with retained ER expression.
Externí odkaz:
https://doaj.org/article/1be00ef29da948768b38964f3c8ef370
Autor:
Pedro Fonseca, Weiyingqi Cui, Nona Struyf, Le Tong, Ayushi Chaurasiya, Felipe Casagrande, Honglei Zhao, Dinura Fernando, Xinsong Chen, Nicholas P. Tobin, Brinton Seashore-Ludlow, Andreas Lundqvist, Johan Hartman, Anita Göndör, Päivi Östling, Lars Holmgren
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)
Abstract Background Tumor cells have the ability to invade and form small clusters that protrude into adjacent tissues, a phenomenon that is frequently observed at the periphery of a tumor as it expands into healthy tissues. The presence of these clu
Externí odkaz:
https://doaj.org/article/33dfb61ce30b4942b583460a044384b6
Autor:
Caroline Rönnlund, Emmanouil G. Sifakis, Caroline Schagerholm, Qiao Yang, Emelie Karlsson, Xinsong Chen, Theodoros Foukakis, Jodi Weidler, Michael Bates, Irma Fredriksson, Stephanie Robertson, Johan Hartman
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Background Overexpression of human epidermal growth factor receptor 2 (HER2) caused by HER2 gene amplification is a driver in breast cancer tumorigenesis. We aimed to investigate the prognostic significance of manual scoring and digital imag
Externí odkaz:
https://doaj.org/article/45539500ca624cfc9e0f07721e2b11cd
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32892- (2024)
Accurate detection of invasive breast cancer (IC) can provide decision support to pathologists as well as improve downstream computational analyses, where detection of IC is a first step. Tissue containing IC is characterized by the presence of speci
Externí odkaz:
https://doaj.org/article/6561ecaa1dbe4322882171bdcf5be06f
Autor:
Balazs Acs, Johan Hartman, Demet Sönmez, Henrik Lindman, Anna L.V. Johansson, Irma Fredriksson
Publikováno v:
The Lancet Regional Health. Europe, Vol 40, Iss , Pp 100886- (2024)
Summary: Background: Estrogen receptor-low (ER-low) HER2-negative breast cancer has similar pathological and molecular characteristics as triple-negative breast cancer (TNBC), and it is questionable whether it should be considered a separate entity.
Externí odkaz:
https://doaj.org/article/1a7320845b114517a9e6a5c7e3942941
Autor:
Abhinav Sharma, Philippe Weitz, Yinxi Wang, Bojing Liu, Johan Vallon-Christersson, Johan Hartman, Mattias Rantalainen
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Background Histological grade is a well-known prognostic factor that is routinely assessed in breast tumours. However, manual assessment of Nottingham Histological Grade (NHG) has high inter-assessor and inter-laboratory variability, causing
Externí odkaz:
https://doaj.org/article/309484264c3c4fdda4194445da60bff5