Phenotypic, Metabolic, and Functional Characterization of Experimental Models of Foamy Macrophages: Toward Therapeutic Research in Atherosclerosis

Autor: Amina Sarah Henni Mansour, Mathilde Ragues, Julien Brevier, Coraline Borowczyk, Janaïna Grevelinger, Jeanny Laroche-Traineau, Johan Garaude, Sébastien Marais, Marie-Josée Jacobin-Valat, Edouard Gerbaud, Gisèle Clofent-Sanchez, Florence Ottones

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 18, p 10146 (2024)

Different types of macrophages (Mφ) are involved in atherogenesis, including inflammatory Mφ and foamy Mφ (FM). Our previous study demonstrated that two-photon excited fluorescence (TPEF) imaging of NADH and FAD autofluorescence (AF) could disting

Externí odkaz: https://doaj.org/article/eea832d06ca74173a9d47d53fc8f69a3

Mitochondrial Complex I activity signals antioxidant response through ERK5

Autor: Abrar Ul Haq Khan, Nerea Allende-Vega, Delphine Gitenay, Johan Garaude, Dang-Nghiem Vo, Sana Belkhala, Sabine Gerbal-Chaloin, Claire Gondeau, Martine Daujat-Chavanieu, Cécile Delettre, Stefania Orecchioni, Giovanna Talarico, Francesco Bertolini, Alberto Anel, José M. Cuezva, Jose A. Enriquez, Guillaume Cartron, Charles-Henri Lecellier, Javier Hernandez, Martin Villalba

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

Abstract Oxidative phosphorylation (OXPHOS) generates ROS as a byproduct of mitochondrial complex I activity. ROS-detoxifying enzymes are made available through the activation of their antioxidant response elements (ARE) in their gene promoters. NRF2

Externí odkaz: https://doaj.org/article/cc2bb76d7c6941359df8d4c75d727c38

Mitochondrial Complex I activity signals antioxidant response through ERK5

Autor: Johan Garaude, Stefania Orecchioni, José Antonio Enríquez, Nerea Allende-Vega, Dang Nghiem Vo, Giovanna Talarico, Javier Hernandez, Sabine Gerbal-Chaloin, Abrar Ul Haq Khan, Martin Villalba, Cécile Delettre, Sana Belkhala, Claire Gondeau, Francesco Bertolini, Charles-Henri Lecellier, José M. Cuezva, Martine Daujat-Chavanieu, Alberto Anel, Guillaume Cartron, Delphine Gitenay

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.7420. ⟨10.1038/s41598-018-23884-4⟩
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-23884-4⟩
Repisalud
Instituto de Salud Carlos III (ISCIII)
Scientific Reports, 2018, 8 (1), pp.7420. ⟨10.1038/s41598-018-23884-4⟩
Digital.CSIC. Repositorio Institucional del CSIC

Oxidative phosphorylation (OXPHOS) generates ROS as a byproduct of mitochondrial complex I activity. ROS-detoxifying enzymes are made available through the activation of their antioxidant response elements (ARE) in their gene promoters. NRF2 binds to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785a1595117916f85243fa2953c1255b
https://doaj.org/article/cc2bb76d7c6941359df8d4c75d727c38

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

Autor: María Mittelbrunn, Francesc Baixauli, Angel Luis Jaso-Tamame, Inmaculada Jorge, Johan Garaude, Gloria González-Aseguinolaza, Noa B. Martín-Cófreces, Miguel Vicente-Manzanares, José Antonio Enríquez, Salvador Iborra, Carolina Villarroya-Beltri, Irene Fernández-Delgado, Rebeca Acín-Pérez, Ana Latorre-Pellicer, Francisco Sánchez-Madrid, Daniel Torralba

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Digital.CSIC. Repositorio Institucional del CSIC
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications

Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9392ca650bf15c65212f0417d48062d
http://hdl.handle.net/20.500.12105/6572

Mobiliser l’immunité innée dans le traitement des cancers

Autor: Johan Garaude

Publikováno v: médecine/sciences. 29:985-990

Immunotherapies are particularly attractive when one wants to fight cancer since they aim at controlling the immune system in order to eradicate cancer cells and prevent tumor dissemination. While the clinical use of specific ligands for the innate i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e45e1f9b3539f923937b7751093e578b
https://doi.org/10.1051/medsci/20132911014