Subgingival microbiome of rheumatoid arthritis patients in relation to their disease status and periodontal health.

Autor: Kathrin Beyer, Egija Zaura, Bernd W Brandt, Mark J Buijs, Johan G Brun, Wim Crielaard, Anne Isine Bolstad

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0202278 (2018)

OBJECTIVE:Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that share common risk factors. However, the bidirectional relationship between RA and periodontal disease is not fully understood. This study was undertaken to d

Externí odkaz: https://doaj.org/article/6b5b1bc7f34847c997eb12b144d9f778

Expression of Toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome.

Autor: Marie Karlsen, Torbjørn Hansen, Hilde H Nordal, Johan G Brun, Roland Jonsson, Silke Appel

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120383 (2015)

IntroductionSjögren's syndrome (SS) is a rheumatic autoimmune disease characterized by inflammation of exocrine glands. As autoantibodies are present in a majority of patients, B cells have been suggested to play an important role in onset and devel

Externí odkaz: https://doaj.org/article/de9afc05f86f49f294da6bca46d34c3b

Aberrant signaling of immune cells in Sjögren’s syndrome patient subgroups upon interferon stimulation

Autor: Irene, Sarkar, Richard, Davies, Anders K, Aarebrot, Silje M, Solberg, Aleksandra, Petrovic, Anagha M, Joshi, Brith, Bergum, Johan G, Brun, Daniel, Hammenfors, Roland, Jonsson, Silke, Appel

Publikováno v: Frontiers in Immunology

BackgroundPrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity and lack of knowledge r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abda4826f567a513b7928a4be25011fd
https://doi.org/10.3389/fimmu.2022.854183

Juvenile Sjogren's Syndrome

Autor: Vibke Lilleby, Malin V. Jonsson, Daniel Hammenfors, Esther Mossel, Johan G. Brun, Juan Carlos Nieto-González, Rosa Maria Rodrigues Pereira, Sandra Gofinet Pasoto, Valeria Valim, Hendrika Bootsma, Clovis A. Silva, Blanca Elena Rios Gomes Bica, Aline Coelho, Akaluck Thatayatikom

Publikováno v: Arthritis Care & Research
Arthritis Care & Research = Arthritis Care and Research
Arthritis Care & Research = Arthritis Care and Research, 2019, 72 (1), pp.78-87. ⟨10.1002/acr.23839⟩
ARTHRITIS CARE & RESEARCH, 72(1), 78-87. Wiley

International audience; Objective. Juvenile Sjögren's syndrome (SS) is a rare, poorly defined, and possibly underdiagnosed condition affecting children and adolescents. The aim of this study was to characterize symptoms and clinical findings of juve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c284f486c5779eedbc993dc65f7d8aed
https://hdl.handle.net/11370/937a4a51-e5bc-470b-895c-dc8c6da6c208

Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells

Autor: Bhuwan, Khatri, Kandice L, Tessneer, Astrid, Rasmussen, Farhang, Aghakhanian, Tove Ragna, Reksten, Adam, Adler, Ilias, Alevizos, Juan-Manuel, Anaya, Lara A, Aqrawi, Eva, Baecklund, Johan G, Brun, Sara Magnusson, Bucher, Maija-Leena, Eloranta, Fiona, Engelke, Helena, Forsblad-d'Elia, Stuart B, Glenn, Daniel, Hammenfors, Juliana, Imgenberg-Kreuz, Janicke Liaaen, Jensen, Svein Joar Auglænd, Johnsen, Malin V, Jonsson, Marika, Kvarnström, Jennifer A, Kelly, He, Li, Thomas, Mandl, Javier, Martín, Gaétane, Nocturne, Katrine Brække, Norheim, Øyvind, Palm, Kathrine, Skarstein, Anna M, Stolarczyk, Kimberly E, Taylor, Maria, Teruel, Elke, Theander, Swamy, Venuturupalli, Daniel J, Wallace, Kiely M, Grundahl, Kimberly S, Hefner, Lida, Radfar, David M, Lewis, Donald U, Stone, C Erick, Kaufman, Michael T, Brennan, Joel M, Guthridge, Judith A, James, R Hal, Scofield, Patrick M, Gaffney, Lindsey A, Criswell, Roland, Jonsson, Per, Eriksson, Simon J, Bowman, Roald, Omdal, Lars, Rönnblom, Blake, Warner, Maureen, Rischmueller, Torsten, Witte, A Darise, Farris, Xavier, Mariette, Marta E, Alarcon-Riquelme, Caroline H, Shiboski, Marie, Wahren-Herlenius, Wan-Fai, Ng, Kathy L, Sivils, Indra, Adrianto, Gunnel, Nordmark, Christopher J, Lessard

Publikováno v: Nature communications. 13(1)

Sjögren's disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren's cases of European ancestry: CD247, NAB1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06cf8bec799422c3df0cd65ff6519afb
https://pubmed.ncbi.nlm.nih.gov/36316359