Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Johan G, de Boer"'
Autor:
Kimberley Hodgson, Patrick B. Walter, Susan J. Murch, Brendan Quiney, Praveen K. Saxena, Cynthia Thomas, Johan G. de Boer
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 578:15-22
We have measured the inhibition of the mutagenicity of the mycotoxin aflatoxin-B1 in the liver of the rat by plant material of Scutellaria baicalensis, or Huang-qin. The addition of one percent dried Huang-qin to the feed of the animals reduced the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c7e4fe09a8a8bf1287dc62b384352f
https://doi.org/10.1016/j.mrfmmm.2005.01.016
https://doi.org/10.1016/j.mrfmmm.2005.01.016
Publikováno v:
Nutrition and Cancer. 50:168-173
Prevention of esophageal cancer may be possible through dietary modification or supplementation. In this study we have investigated the mutation preventive properties of ellagic acid, green tea, and diallyl sulfide (DAS) against the mutagenicity of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e249a03ab253765bad61a6703c815678
https://doi.org/10.1207/s15327914nc5002_6
https://doi.org/10.1207/s15327914nc5002_6
Autor:
Johan G. de Boer
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 509:201-210
The repair of damage to DNA is critical to the survival of a cell. However, not all organisms nor all individuals express a similar response to challenges to their genetic material. Numerous polymorphisms in genes involved in DNA repair have been fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150a73cb8cf2c03aaee762a362a041c4
https://doi.org/10.1016/s0027-5107(02)00217-8
https://doi.org/10.1016/s0027-5107(02)00217-8
Publikováno v:
Environmental and Molecular Mutagenesis. 40:116-121
The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a recognized mutagen and carcinogen in the colon and prostate of male rats and in the mammary gland of female rats. In the current study, we examined the mutagenicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0309f0e9fd660f0d4f66ae353c33235a
https://doi.org/10.1002/em.10096
https://doi.org/10.1002/em.10096
Autor:
Amanda Thornton, Haiyan Yang, Barry W. Glickman, Johan G. de Boer, Jana Kangas, James Holcroft, Roderick Haesevoets, Ken Sojonky, David Walsh, Gregory R. Stuart, Erika Thorleifson
Publikováno v:
Mutagenesis. 16:431-437
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a food-borne mutagen and carcinogen that induces tumors of the colon and the prostate gland in male rats and of the mammary gland in female rats. In this study we describe the frequency and sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b313ccb162d8d3f2958e8862e5ea943
https://doi.org/10.1093/mutage/16.5.431
https://doi.org/10.1093/mutage/16.5.431
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. :147-151
We assessed the ability of green tea to protect against benzo[a]pyrene (B[a]P)-induced mutations in the liver of lacI transgenic male C57BL/6 Big Blue mice. The mice were given a 2% Japanese green tea hot water extract as their sole source of drinkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe3822d415cdcc0f6f138d94365c54b
https://doi.org/10.1016/s0027-5107(01)00178-6
https://doi.org/10.1016/s0027-5107(01)00178-6
Publikováno v:
Environmental and Molecular Mutagenesis. 37:141-146
Comparison of spontaneous mutation spectra derived from different transgenic constructs can provide valuable insights for interpreting the mechanisms of spontaneous mutation. In this study, spontaneous mutation frequencies and spectra of the lacI tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c15c40abbb0f5ea2bdd6fb06830e067
https://doi.org/10.1002/em.1021
https://doi.org/10.1002/em.1021
Autor:
Gregory R. Stuart, Minako Nagao, Johan G. de Boer, Eriko Okochi, Erika Thorleifson, Toshikazu Ushijima, Barry W. Glickman
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 452:101-121
The cII assay provides an alternative choice to the lacI transgene for mutational studies involving Big Blue(R) transgenic mice and rats, or permits the evaluation of mutational responses in both genes. Here, we compare the mutational response of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922475333245d14f0721149d8b8f1cf4
https://doi.org/10.1016/s0027-5107(00)00058-0
https://doi.org/10.1016/s0027-5107(00)00058-0
Autor:
Anne Constable, Sandra A.M. Bol, Robert J. Turesky, Jovanka Markovic, Janine Horlbeck, Johan G. de Boer
Publikováno v:
Carcinogenesis. 21:1-6
The heterocyclic aromatic amine (HAA) 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) induces intestinal tumours and hepatocellular carcinomas in rats, but no tumourigenic effects have been identified in the kidney. The tissue-specific mutagenicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5aaf298fe2b12442d5edbbbbc98f8e6
https://doi.org/10.1093/carcin/21.1.1
https://doi.org/10.1093/carcin/21.1.1
Autor:
Kathleen Dixon, Glenn Talaska, Anastasia Andringa, Marian L. Miller, Kersi Vasunia, Johan G. de Boer
Publikováno v:
Environmental and Molecular Mutagenesis. 35:319-327
The Big Blue mouse was used to investigate the role of cell proliferation in mutation fixation in the mouse back skin model of carcinogenesis. Phorbol 12-myristate 13 acetate (TPA) was applied to the dorsum of Big Blue mice to manipulate cell prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c9ef9fcac7d88464bf80cc3c3937037
https://doi.org/10.1002/1098-2280(2000)35:4<319::aid-em6>3.0.co
https://doi.org/10.1002/1098-2280(2000)35:4<319::aid-em6>3.0.co