The Tonsil Lymphocyte Landscape in Pediatric Tonsil Hyperplasia and Obstructive Sleep Apnea

Autor: Anna Carrasco, Isabella Sjölander, Aline Van Acker, Andy Dernstedt, Johan Fehrm, Mattias Forsell, Danielle Friberg, Jenny Mjösberg, Anna Rao

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Tonsil hyperplasia is the most common cause of pediatric obstructive sleep apnea (OSA). Despite the growing knowledge in tissue immunology of tonsils, the immunopathology driving tonsil hyperplasia and OSA remains unknown. Here we used multi-parametr

Externí odkaz: https://doaj.org/article/a14ca8cb8e5b4485b29ef756023f0119

Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue

Autor: Jenny Mjösberg, Marianne Forkel, Annika C. Karlsson, Joar Sundman, Jovana Maric, Joshua Lange, Danielle Friberg, Takuya Sekine, Efthymia Kokkinou, Emma B. Hodcroft, Whitney Weigel, Luca Mazzurana, Marcus Buggert, David Price, Sian Llewellyn-Lacey, Julia Niessl, Johan Fehrm, Anna Rao, Viktoria Konya

Publikováno v: Niessl, Julia; Sekine, Takuya; Lange, Joshua; Konya, Viktoria; Forkel, Marianne; Maric, Jovana; Rao, Anna; Mazzurana, Luca; Kokkinou, Efthymia; Weigel, Whitney; Llewellyn-Lacey, Sian; Hodcroft, Emma B.; Karlsson, Annika C; Fehrm, Johan; Sundman, Joar; Price, David A; Mjösberg, Jenny; Friberg, Danielle; Buggert, Marcus (2021). Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue. Science immunology, 6(64), eabk0894. American Association for the Advancement of Science 10.1126/sciimmunol.abk0894

Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed individuals compared with SARS-CoV-2–reactive CD8+ T cells. However, large numbe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f38b103e1e24c0916040a3fd58525fa
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-460082

Postoperative morbidity after adenotonsillectomy versus adenopharyngoplasty in young children with obstructive sleep apnea : an RCT

Autor: Pia Nerfeldt, Anna Borgström, Danielle Friberg, Johan Fehrm

Publikováno v: European Archives of Oto-Rhino-Laryngology

Purpose In our previous randomized controlled trial (RCT), comparing adenotonsillectomy (ATE) with adenopharyngoplasty (APP) in children with severe obstructive sleep apnea (OSA), there were no differences in respiratory sleep parameters or quality o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea65e1e92469011f229df64f8531f427
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-417073

Adenopharyngoplasty vs Adenotonsillectomy in Children With Severe Obstructive Sleep Apnea: A Randomized Clinical Trial

Autor: Pia Nerfeldt, Johan Fehrm, Joar Sundman, Danielle Friberg

Publikováno v: JAMA otolaryngology-- headneck surgery. 144(7)

IMPORTANCE: Adenotonsillectomy (ATE) is the primary surgical method for treating obstructive sleep apnea (OSA) in children. However, children with severe OSA have an increased risk for residual OSA after ATE. Previous studies indicate that adenophary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4d7ec293a89067f12cb116310a0f6a
https://pubmed.ncbi.nlm.nih.gov/29852045

Blood pressure after modified uvulopalatopharyngoplasty: results from the SKUP

Autor: Johan, Fehrm, Danielle, Friberg, Johan, Bring, Nanna, Browaldh

Publikováno v: Sleep medicine. 34

Obstructive sleep apnea (OSA) is a risk factor for hypertension. The SKUPWe used a single-center randomized controlled trial to compare modified UPPP with controls at baseline and after six months. The controls received delayed surgery with an additi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4c7ad7b12af00c69260fcf09d951534
https://pubmed.ncbi.nlm.nih.gov/28522085