Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Johan F.J. Engbersen"'
Publikováno v:
Journal of materials chemistry. B. 6(2)
Water-soluble, nano-sized crosslinked polymer networks, or nanogels, are delivery vehicles, which have highly interesting properties for therapeutic delivery and imaging. Nanogels may also possess responsive properties, depending on the employed poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170d4c58e929e18a2c48cb3478aec330
https://pubmed.ncbi.nlm.nih.gov/32254164
https://pubmed.ncbi.nlm.nih.gov/32254164
Autor:
Raymond M. Schiffelers, Lies A. L. Fliervoet, Wim E. Hennink, Johan F.J. Engbersen, Tina Vermonden
Publikováno v:
Journal of Materials Chemistry B. 6(36):5651-5670
The potential of gene therapy for the treatment for chronic and life-threatening diseases has been seen for a long time, but widespread applications are still hampered by the difficulties to deliver the highly charged and large nucleic acid molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faba939666851956abd1589a92bf7191
http://www.scopus.com/inward/record.url?scp=85053730295&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85053730295&partnerID=8YFLogxK
Autor:
Jos M. J. Paulusse, Antonie E. Ekkelenkamp, Johan F.J. Engbersen, Karin Roelofs, Michelle M. T. Jansman
Publikováno v:
Acta biomaterialia, 30, 126-134. Elsevier
Narrowly dispersed zwitterionic poly(amido amine) (PAA) nanogels with a diameter of approximately 100nm were prepared by a high-yielding and surfactant-free, inverse nanoprecipitation of PAA polymers. The resulting, negatively charged, nanogels (PAA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf653d134e461764a4d31487f775922
https://doi.org/10.1016/j.actbio.2015.10.037
https://doi.org/10.1016/j.actbio.2015.10.037
Autor:
G.M.J.P.C. Coué, Ronald E. Unger, Leto Tziveleka, Frank Sinner, Harry W.M. Steinbusch, Eleonore Fröhlich, Krystyna Albrecht, Christoph Schmitz, Maria Sánchez-Purrà, Pilar Martinez-Martinez, Smriti Singh, Jürgen Groll, Ewoud C. van Winden, Christian Freese, Christian Grandfils, Salvador Borrós, Berta Albaiges, Hans Georg Frank, C. James Kirkpatrick, Andy J.G. Pötgens, Karin E. Pickl, Gerard H. Bode, Johan F.J. Engbersen, Zili Sideratou, Martin Möller
Publikováno v:
Nanomedicine-Nanotechnology Biology and Medicine, 13(3), 1289-1300. Elsevier Science
Nanomedicine : nanotechnology, biology and medicine, 13(3), 1289-1300. Elsevier
Nanomedicine : nanotechnology, biology and medicine, 13(3), 1289-1300. Elsevier
Targeted delivery of drugs across endothelial barriers remains a formidable challenge, especially in the case of the brain, where the blood-brain barrier severely limits entry of drugs into the central nervous system. Nanoparticle-mediated transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9053d989ca6bf8f8352b139596a1178
https://cris.maastrichtuniversity.nl/en/publications/0657ddb6-7c57-4a6c-ae0b-f821ccdff6bc
https://cris.maastrichtuniversity.nl/en/publications/0657ddb6-7c57-4a6c-ae0b-f821ccdff6bc
Publikováno v:
Current Topics in Medicinal Chemistry. 12:108-119
RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60f2bf1a02672ca3d9866c13a320494
https://doi.org/10.2174/156802612798919123
https://doi.org/10.2174/156802612798919123
Publikováno v:
Biomaterials, 33(2), 614-623. Elsevier
An effective intracellular protein delivery system was developed based on linear poly(amidoamine)s (PAAs) that form self-assembled cationic nanocomplexes with oppositely charged proteins. Two differently functionalized PAAs were synthesized by Michae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efa5dd397d9535efc348c970f9fa98f
https://doi.org/10.1016/j.biomaterials.2011.09.085
https://doi.org/10.1016/j.biomaterials.2011.09.085
Autor:
Johan F.J. Engbersen, Raymond M. Schiffelers, Gert Storm, Pieter Vader, Leonardus J. van der Aa
Publikováno v:
Pharmaceutical Research
Pharmaceutical research, 29(2), 352-361. Springer
Pharmaceutical research, 29(2), 352-361. Springer
Purpose Use of RNA interference as novel therapeutic strategy is hampered by inefficient delivery of its mediator, siRNA, to target cells. Cationic polymers have been thoroughly investigated for this purpose but often display unfavorable characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e91f7e1d808a596c97560d89181e20
http://europepmc.org/articles/PMC3264854
http://europepmc.org/articles/PMC3264854
Autor:
Arwyn Tomos Jones, Leonardus J. van der Aa, Martin Piest, Dries Vercauteren, Kevin Braeckmans, Monerah Al Soraj, Johan F.J. Engbersen, Stefaan C. De Smedt
Publikováno v:
Biomaterials, 32(11), 3072-3084. Elsevier
Extensive research is currently performed on designing safe and efficient non-viral carriers for gene delivery. To increase their efficiency, it is essential to have a thorough understanding of the mechanisms involved in cellular attachment, internal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfe0d1d751432dced2ba2a7f4f60ec8
https://doi.org/10.1016/j.biomaterials.2010.12.045
https://doi.org/10.1016/j.biomaterials.2010.12.045
Publikováno v:
Journal of controlled release, 150(2), 177-186. Elsevier
By Michael addition polymerization of N,N'-cystaminebisacrylamide (CBA) with variable ratios of 4-amino-1-butanol (ABOL) and ethylene diamine (EDA) or triethylenetetramine (TETA), poly(amido amine) copolymers could be obtained with tunable charge den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e025074b66d76aa65042fcb9d8b2590f
https://doi.org/10.1016/j.jconrel.2010.11.030
https://doi.org/10.1016/j.jconrel.2010.11.030
Autor:
Dries Vercauteren, Stefaan C. De Smedt, Kevin Braeckmans, Arwyn Tomos Jones, Hendrik Deschout, Katrien Remaut, Johan F.J. Engbersen, Jo Demeester
Publikováno v:
ACS nano, 5(10), 7874-7884. American Chemical Society
To gain a better understanding of intracellular processing of nanomedicines, we employed quantitative live-cell fluorescence colocalization microscopy to study endosomal trafficking of polyplexes in retinal pigment epithelium cells. A new, dynamic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf554caf23dda0e9c470da98758f7383
https://doi.org/10.1021/nn2020858
https://doi.org/10.1021/nn2020858