Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Johan F, Paulsson"'
Autor:
Søren Østergaard, Johan F. Paulsson, Jacob Kofoed, Franziska Zosel, Jørgen Olsen, Claus Bekker Jeppesen, Jane Spetzler, Lars Ynddal, Luise Gram Schleiss, Berit Østergaard Christoffersen, Kirsten Raun, Ulrich Sensfuss, Flemming Seier Nielsen, Rasmus Jørgensen, Birgitte S. Wulff
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Peptides are notoriously known to display very short in vivo half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain long half-lives allowing for up to once-weekly dosing
Externí odkaz:
https://doaj.org/article/cec7ec4e645c44c5a30946919c1e7741
Autor:
Rasmus Jorgensen, Luise Gram Schleiss, Kirsten Raun, Jacob Kofoed, Claus Bekker Jeppesen, Birgitte Schjellerup Wulff, Berit Østergaard Christoffersen, Jørgen Olsen, Lars Ynddal, Franziska Zosel, Ulrich Sensfuss, Johan F. Paulsson, Søren Østergaard, Jane Spetzler, Flemming S Nielsen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Peptides are notoriously known to display very short in vivo half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain long half-lives allowing for up to once-weekly dosing regimen,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b070773ae97f4392dec87755c1751435
https://doaj.org/article/cec7ec4e645c44c5a30946919c1e7741
https://doaj.org/article/cec7ec4e645c44c5a30946919c1e7741
Autor:
Johan F. Paulsson, Jens Kaalby Thomsen, Annika Lindgren Sjölander, Christian Poulsen, Birgitte Schjellerup Wulff, Per-Olof Wahlund, Kilian Conde-Frieboes, Søren Østergaard, Marie Østergaard Pedersen
Publikováno v:
Pharmaceutical Research. 38:1369-1385
The anorectic effect of PYY3–36 makes it a potential pharmacological weight loss treatment. Modifications of the endogenous peptide to obtain commercially attractive pharmacological and biophysical stability properties are examined. Half-life exten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f411fe986b05fc92f7569a83399866d
https://doi.org/10.1007/s11095-021-03077-x
https://doi.org/10.1007/s11095-021-03077-x
High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
Autor:
Johan F Paulsson, Johnny Ludvigsson, Annelie Carlsson, Rosaura Casas, Gun Forsander, Sten A Ivarsson, Ingrid Kockum, Åke Lernmark, Claude Marcus, Bengt Lindblad, Gunilla T Westermark
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93053 (2014)
Aims/hypothesisIslet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid.
Externí odkaz:
https://doaj.org/article/fe2016a67c664464a2a995edd28a451e
Autor:
Christian, Poulsen, Marie Østergaard, Pedersen, Per-Olof, Wahlund, Annika, Sjölander, Jens Kaalby, Thomsen, Kilian W, Conde-Frieboes, Johan F, Paulsson, Birgitte S, Wulff, Søren, Østergaard
Publikováno v:
Pharmaceutical research. 38(8)
The anorectic effect of PYYHalf-life extended PYYDeamidation of asparagine in position 18 and 29 was observed upon incubation at 37°C. Asparagine in position 18 - but not position 29 - could be substituted to glutamine without detrimental effects on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44eba2d1563d226835592aabd480e098
https://pubmed.ncbi.nlm.nih.gov/34272643
https://pubmed.ncbi.nlm.nih.gov/34272643
Autor:
Jacob Kofoed, Rasmus Jorgensen, Birgitte Schjellerup Wulff, Kim G. Madsen, Johan F. Paulsson, Søren Dinesen Østergaard
Publikováno v:
Journal of Medicinal Chemistry. 61:10519-10530
In recent years peptide YY (PYY) has attracted attention within the area of diabetes and obesity due to its involvement in food intake regulation and glucose homeostasis. It is well-known that PYY1–36 is rapidly cleaved by dipeptidyl peptidase-4 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cd84dac6651c1b1815b41141ba5b1a6
https://doi.org/10.1021/acs.jmedchem.8b01046
https://doi.org/10.1021/acs.jmedchem.8b01046
Autor:
Petr, Zouhar, Günaj, Rakipovski, Muhammad Hamza, Bokhari, Oliver, Busby, Johan F, Paulsson, Kilian W, Conde-Frieboes, Johannes J, Fels, Kirsten, Raun, Birgitte, Andersen, Barbara, Cannon, Jan, Nedergaard
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism
The possibility to use leptin therapeutically for lowering glucose levels in patients with type 1 diabetes has attracted interest. However, earlier animal models of type 1 diabetes are severely catabolic with very low endogenous leptin levels, unlike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63eabe2f880be82adf1e7bb2d9cc7e8d
https://pubmed.ncbi.nlm.nih.gov/31743040
https://pubmed.ncbi.nlm.nih.gov/31743040
Autor:
Emil Egecioglu, Majken Dalgaard, Marie Østergaard Pedersen, Birgitte Schjellerup Wulff, Mikala Skydsgaard, Alan Broadmeadow, Clare J. Chesher, Ridhirama Bhuwania, Esther Bloem, Emma Moore, Manuel Tena-Sempere, Hannah Williams, Lærke W. Andersen, Pia Søndergaard Galle, Florian Bolze, Johan F. Paulsson
Publikováno v:
Toxicology and Applied Pharmacology. 404:115152
Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711c0139312e6bed6d38c6b05112dbcd
https://doi.org/10.1016/j.taap.2020.115152
https://doi.org/10.1016/j.taap.2020.115152
Autor:
Søren, Østergaard, Jacob, Kofoed, Johan F, Paulsson, Kim Grimstrup, Madsen, Rasmus, Jorgensen, Birgitte S, Wulff
Publikováno v:
Journal of medicinal chemistry. 61(23)
In recent years peptide YY (PYY) has attracted attention within the area of diabetes and obesity due to its involvement in food intake regulation and glucose homeostasis. It is well-known that PYY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdc8e9ec704caefc0f0316c99fc70760
https://pubmed.ncbi.nlm.nih.gov/30399314
https://pubmed.ncbi.nlm.nih.gov/30399314
Autor:
Bo, Xu, Silvana, Vasile, Søren, Østergaard, Johan F, Paulsson, Jasna, Pruner, Johan, Åqvist, Birgitte S, Wulff, Hugo, Gutiérrez-de-Terán, Dan, Larhammar
Publikováno v:
Molecular pharmacology. 93(4)
Understanding the agonist-receptor interactions in the neuropeptide Y (NPY)/peptide YY (PYY) signaling system is fundamental for the design of novel modulators of appetite regulation. We report here the results of a multidisciplinary approach to eluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f5061ef7669cb4f08055397137e096a
https://pubmed.ncbi.nlm.nih.gov/29367257
https://pubmed.ncbi.nlm.nih.gov/29367257