Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Johan Evenäs"'
Autor:
Melissa A. Graewert, Maria Volkova, Klara Jonasson, Juha A. E. Määttä, Tobias Gräwert, Samara Mamidi, Natalia Kulesskaya, Johan Evenäs, Richard E. Johnsson, Dmitri Svergun, Arnab Bhattacharjee, Henri J. Huttunen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that is a disease-modifying drug candidate for Parkinson’s disease. CDNF has pleiotropic protective effects on stressed cells, but its mechanism of actio
Externí odkaz:
https://doaj.org/article/96e49cedbeaa44d2becdda52aada34c8
Autor:
Shireen Mohammad, Caroline E. O’Riordan, Chiara Verra, Eleonora Aimaretti, Gustavo Ferreira Alves, Klaus Dreisch, Johan Evenäs, Patrizia Gena, Angela Tesse, Michael Rützler, Massimo Collino, Giuseppe Calamita, Christoph Thiemermann
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Sepsis is caused by systemic infection and is a major health concern as it is the primary cause of death from infection. It is the leading cause of mortality worldwide and there are no specific effective treatments for sepsis. Gene deletion of the ne
Externí odkaz:
https://doaj.org/article/1a16582065b24e0894afbde23cc9667f
Autor:
Perry Matthew, Fredrik Edfeldt, Isabella Feierberg, Mattias Rohman, Johan Evenäs, Alison Ward, Jens Petersen, Ulf Sivars, Thomas Hansson, Lisa Wissler, Karin Svensson, Xiao-Hong Zhou, Frank Narjes, Matti Lepistö
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2496-2500
Human H-PGDS has shown promise as a potential target for anti-allergic and anti-inflammatory drugs. Here we describe the discovery of a novel class of indole inhibitors, identified through focused screening of 42,000 compounds and evaluated using a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9988fa1de7d07f0fb2c45aebc4c722a4
https://doi.org/10.1016/j.bmcl.2015.04.065
https://doi.org/10.1016/j.bmcl.2015.04.065
Autor:
Predrag Kukic, Patrik Lundström, Mikael Akke, Michele Vendruscolo, Johan Evenäs, Carlo Camilloni
Publikováno v:
Biochemistry. 55(1)
Calmodulin is a two-domain signaling protein that becomes activated upon binding cooperatively two pairs of calcium ions, leading to large-scale conformational changes that expose its binding site. Despite significant advances in understanding the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6190e579ed7ede2b52967a339a24d7
https://pubmed.ncbi.nlm.nih.gov/26618792
https://pubmed.ncbi.nlm.nih.gov/26618792
Publikováno v:
Biophysical Journal. 89:4219-4233
The influence of molecular characteristics on the mutual interaction between peptides and nonionic surfactants has been investigated by studying the effects of surfactants on amphiphilic, random copolymers of alpha-L-amino acids containing lysine res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc53a34827118928bc9ababfe3665e2
https://doi.org/10.1529/biophysj.105.065342
https://doi.org/10.1529/biophysj.105.065342
Autor:
Maria U. Johansson, Torbjörn Drakenberg, Sture Forsén, Hanna Nilsson, Mats Wikström, Johan Evenäs, Lars Björck
Publikováno v:
Journal of Molecular Biology. 316:1083-1099
Proteins G and PAB are bacterial albumin-binding proteins expressed at the surface of group C and G streptococci and Peptostreptococcus magnus, respectively. Repeated albumin-binding domains, known as GA modules, are found in both proteins. The third
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0bf11cd540fee72dea8bc95d95fb69
https://doi.org/10.1006/jmbi.2002.5398
https://doi.org/10.1006/jmbi.2002.5398
Autor:
Andreas Muranyi, Garry P. Gippert, Maria Håkansson, Jonas Fast, L. Anders Svensson,§,▾ and, Johan Evenäs, Eva Thulin, Sara Linse
Publikováno v:
Biochemistry. 40:9887-9895
Water molecules are found to complete the Ca2+ coordination sphere when a protein fails to provide enough ligating oxygens. Hydrogen bonding of these water molecules to the protein backbone or side chains may contribute favorably to the Ca2+ affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2d3e183d88d9761819422d03556099
https://doi.org/10.1021/bi010551h
https://doi.org/10.1021/bi010551h
Autor:
Vitali Tugarinov, Johan Evenäs, Natalie K. Goto, Lewis E. Kay, Nikolai R. Skrynnikov, Ranjith Muhandiram
Publikováno v:
Journal of Molecular Biology. 309:961-974
Solution NMR studies on the physiologically relevant ligand-free and maltotriose-bound states of maltodextrin-binding protein (MBP) are presented. Together with existing data on MBP in complex with beta-cyclodextrin (non-physiological, inactive ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f550f2201942bd2df9d74ef566b09a7
https://doi.org/10.1006/jmbi.2001.4695
https://doi.org/10.1006/jmbi.2001.4695
Publikováno v:
Journal of the American Chemical Society. 123:2858-2864
TROSY-based HN(CO)CA 2D and 3D pulse schemes are presented for measurement of (13)C(alpha)-(13)C(beta) dipolar couplings in high molecular weight (15)N,(13)C,(2)H-labeled proteins. In one approach, (13)C(alpha)-(13)C(beta) dipolar couplings are obtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e2b155bd993edd3128589ba5432de7
https://doi.org/10.1021/ja003833y
https://doi.org/10.1021/ja003833y
Publikováno v:
FEBS Letters. 475:135-138
Vitamin K-dependent protein S, which is a cofactor for activated protein C and thus important for down-regulation of the coagulation cascade, contains several Ca 2+ -binding sites with unusually high affinity. The 89 amino acid fragment constituting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67abaf4147d28629ae2f3b6837ac74a5
https://doi.org/10.1016/s0014-5793(00)01636-7
https://doi.org/10.1016/s0014-5793(00)01636-7