Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Johan E Larsson"'
Publikováno v:
eLife, Vol 7 (2018)
The voltage-gated potassium channel KV7.1 and the auxiliary subunit KCNE1 together form the cardiac IKs channel, which is a proposed target for future anti-arrhythmic drugs. We previously showed that polyunsaturated fatty acids (PUFAs) activate KV7.1
Externí odkaz:
https://doaj.org/article/76afcc4292c34739b5d68f68e35d6b4e
Autor:
Inge Schjødt, Rikke E. Mols, István Bakos, Erzsébet Horváth‐Puhó, Finn Gustafsson, Søren L. Kristensen, Johan E. Larsson, Bo Christensen, Hans Eiskjær, Brian B. Løgstrup
Publikováno v:
ESC Heart Failure, Vol 11, Iss 4, Pp 1919-1931 (2024)
Abstract Aims Increasing numbers of patients with advanced heart failure and significant comorbidity and social barriers are considered for left ventricular assist devices (LVADs). We sought to examine health care utilization post‐LVAD implantation
Externí odkaz:
https://doaj.org/article/0d195e54760f4697ab3fd7b4034d2173
Publikováno v:
eLife, Vol 5 (2016)
About 300 loss-of-function mutations in the IKs channel have been identified in patients with Long QT syndrome and cardiac arrhythmia. How specific mutations cause arrhythmia is largely unknown and there are no approved IKs channel activators for tre
Externí odkaz:
https://doaj.org/article/577750b783cd40319102b86659220237
Autor:
Martin Schønemann-Lund, Theis S. Itenov, Johan E. Larsson, Birgitte Lindegaard, Pär I. Johansson, Morten H. Bestle
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-15 (2022)
Abstract Background Endotheliopathy is suggested as pivotal pathophysiology of sepsis and trauma-associated organ failure, but its role in acute respiratory failure is not yet determined. We investigated if endotheliopathy biomarkers at ICU admission
Externí odkaz:
https://doaj.org/article/c7e3e9fe6109417f8a13626fb93fd17c
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Voltage-gated potassium channels of the KV7 family are expressed in many tissues. The physiological importance of KV7 channels is evident from specific forms of disorders linked to dysfunctional KV7 channels, including variants of epilepsy, cardiac a
Externí odkaz:
https://doaj.org/article/a129530b003c4a6ea81216b70e5d1701
Publikováno v:
The Journal of General Physiology
The anticonvulsant retigabine targets the neuronal M-channel but has adverse clinical effects due to its poor KV7 subtype specificity. Larsson et al. reveal that the selectivity of retigabine is improved by coapplication with the endocannabinoid arac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9e324ada8221d9eac6f7261098d3a6c1
http://europepmc.org/articles/PMC7398146
http://europepmc.org/articles/PMC7398146
Publikováno v:
The Journal of General Physiology
There exist many different ion channel modulators that inhibit channel function, but few that increase it. Liin et al. tested 18,000 compounds by high-throughput electrophysiology and found several channel openers with a biaryl-sulfonamide motif that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaafcfe73ae7801d509ddb0d26c483aa
http://europepmc.org/articles/PMC6080886
http://europepmc.org/articles/PMC6080886
Autor:
Johan E. Larsson, Samira Yazdi, Peter Tieleman, Williams E. Miranda, Valentina Corradi, Sergei Y. Noskov, Peter Larsson, Sara I. Liin
Publikováno v:
Biophysical Journal. 118:168a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::402772aac5aa77dc2cb53303d5c57e2a
https://doi.org/10.1016/j.bpj.2019.11.1032
https://doi.org/10.1016/j.bpj.2019.11.1032
Publikováno v:
Biophysical Journal. 118:109a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f98191540478471bc3369bd47a82579
https://doi.org/10.1016/j.bpj.2019.11.747
https://doi.org/10.1016/j.bpj.2019.11.747
