A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion

Autor: Antoine A. Khalil, Daan Smits, Peter D. Haughton, Thijs Koorman, Karin A. Jansen, Mathijs P. Verhagen, Mirjam van der Net, Kitty van Zwieten, Lotte Enserink, Lisa Jansen, Abdelrahman G. El-Gammal, Daan Visser, Milena Pasolli, Max Tak, Denise Westland, Paul J. van Diest, Cathy B. Moelans, M. Guy Roukens, Sandra Tavares, Anne-Marie Fortier, Morag Park, Riccardo Fodde, Martijn Gloerich, Fried. J. T. Zwartkruis, Patrick WB. Derksen, Johan de Rooij

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Dense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells (basal-like cells) maintain several epithelial characteristic

Externí odkaz: https://doaj.org/article/50e49d8f27e74b6aa43d0874b11c6389

Force transduction by cadherin adhesions in morphogenesis [version 1; peer review: 3 approved]

Autor: Willem-Jan Pannekoek, Johan de Rooij, Martijn Gloerich

Publikováno v: F1000Research, Vol 8 (2019)

Mechanical forces drive the remodeling of tissues during morphogenesis. This relies on the transmission of forces between cells by cadherin-based adherens junctions, which couple the force-generating actomyosin cytoskeletons of neighboring cells. Mor

Externí odkaz: https://doaj.org/article/d73abc2064584a36b5ade948bc890b63

The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

Autor: Yvonne L. Dorland, Tsveta S. Malinova, Anne-Marieke D. van Stalborch, Adam G. Grieve, Daphne van Geemen, Nicolette S. Jansen, Bart-Jan de Kreuk, Kalim Nawaz, Jeroen Kole, Dirk Geerts, René J. P. Musters, Johan de Rooij, Peter L. Hordijk, Stephan Huveneers

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)

Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens Junc

Externí odkaz: https://doaj.org/article/39489597f19d45109896f9a7f11b9fb8

Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation

Autor: Floor Twiss, Quint Le Duc, Suzanne Van Der Horst, Hamid Tabdili, Gerard Van Der Krogt, Ning Wang, Holger Rehmann, Stephan Huveneers, Deborah E. Leckband, Johan De Rooij

Publikováno v: Biology Open, Vol 1, Iss 11, Pp 1128-1140 (2012)

Summary Proper regulation of the formation and stabilization of epithelial cell–cell adhesion is crucial in embryonic morphogenesis and tissue repair processes. Defects in this process lead to organ malformation and defective epithelial barrier fun

Externí odkaz: https://doaj.org/article/475896539af044ddabe3c8bb4d38de38

The Effect of Preanalytical and Physiological Variables on Cell-Free DNA Fragmentation

Autor: Ymke van der Pol, Norbert Moldovan, Sandra Verkuijlen, Jip Ramaker, Dries Boers, Wendy Onstenk, Johan de Rooij, Idris Bahce, D Michiel Pegtel, Florent Mouliere

Publikováno v: van der Pol, Y, Moldovan, N, Verkuijlen, S, Ramaker, J, Boers, D, Onstenk, W, de Rooij, J, Bahce, I, Pegtel, D M & Mouliere, F 2022, ' The Effect of Preanalytical and Physiological Variables on Cell-Free DNA Fragmentation ', Clinical Chemistry, vol. 68, no. 6, pp. 803-813 . https://doi.org/10.1093/clinchem/hvac029
Clinical Chemistry, 68(6), 803-813

BackgroundAssays that account for the biological properties and fragmentation of cell-free DNA (cfDNA) can improve the performance of liquid biopsy. However, preanalytic and physiological differences between individuals on fragmentomic analysis are p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32ce0551ecead9265eb222612986c06
https://research.vumc.nl/en/publications/6586d772-4522-4a1d-af1d-7028808e23db