Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

Autor: Samira Salihovic, Niklas Nyström, Charlotte Bache-Wiig Mathisen, Robert Kruse, Christine Olbjørn, Svend Andersen, Alexandra J. Noble, Maria Dorn-Rasmussen, Igor Bazov, Gøri Perminow, Randi Opheim, Trond Espen Detlie, Gert Huppertz-Hauss, Charlotte R. H. Hedin, Marie Carlson, Lena Öhman, Maria K. Magnusson, Åsa V. Keita, Johan D. Söderholm, Mauro D’Amato, Matej Orešič, Vibeke Wewer, Jack Satsangi, Carl Mårten Lindqvist, Johan Burisch, Holm H. Uhlig, Dirk Repsilber, Tuulia Hyötyläinen, Marte Lie Høivik, Jonas Halfvarson

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naï

Externí odkaz: https://doaj.org/article/8a477108fc6e4a34a2cccb17d607374e

Increased Numbers of Enteric Glial Cells in the Peyer’s Patches and Enhanced Intestinal Permeability by Glial Cell Mediators in Patients with Ileal Crohn’s Disease

Autor: Olga Biskou, Felipe Meira de-Faria, Susanna M. Walter, Martin E. Winberg, Staffan Haapaniemi, Pär Myrelid, Johan D. Söderholm, Åsa V. Keita

Publikováno v: Cells, Vol 11, Iss 3, p 335 (2022)

Enteric glial cells (EGC) are known to regulate gastrointestinal functions; however, their role in Crohn’s disease (CD) is elusive. Microscopic erosions over the ileal Peyer’s patches are early signs of CD. The aim of this work was to assess the

Externí odkaz: https://doaj.org/article/7498af27187d40b4ab6ff61980dde0e1

Possible Involvement of Intracellular Calcium-Independent Phospholipase A2 in the Release of Secretory Phospholipases from Mast Cells—Increased Expression in Ileal Mast Cells of Crohn’s Disease

Autor: Ulrika Christerson, Åsa V. Keita, Martin E. Winberg, Johan D. Söderholm, Christina Gustafson-Svärd

Publikováno v: Cells, Vol 8, Iss 7, p 672 (2019)

Increased activity of secretory phospholipases A2 (sPLA2) type-II was previously observed in ileum of Crohn’s disease (CD). Our aims were to explore the involvement of calcium-independent (i)PLA2β in the release of sPLA2s from the human mast cell

Externí odkaz: https://doaj.org/article/aa9613a3f91845a0b27c62ff5181ca11

Analysis of Systemic Epigenetic Alterations in Inflammatory Bowel Disease: Defining Geographical, Genetic and Immune-Inflammatory influences on the Circulating Methylome

Autor: Mauro D'Amato, Petr Ricanek, Alex Adams, Jonas Christoffer Lindstrøm, Nicholas A. Kennedy, Morten H. Vatn, Fernando Gomollón, Nicholas T. Ventham, Jonas Halfvarson, Christine Olbjørn, Rahul Kalla, Johan D. Söderholm, Daniel Bergemalm, Simen Vatn, Rebecca C Richmond, Jan Krzysztof Nowak, Caroline L Relton, Jørgen Jahnsen, Jack Satsangi, Marieke Pierik

Publikováno v: Journal of Crohn's & Colitis, 17(2), 170-184. Oxford University Press

Background Epigenetic alterations may provide valuable insights into gene–environment interactions in the pathogenesis of inflammatory bowel disease [IBD]. Methods Genome-wide methylation was measured from peripheral blood using the Illumina 450k p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079c3041e49e3aea6df6864b62c84c43
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190960

Whole Blood Profiling of T-cell-Derived microRNA Allows the Development of Prognostic models in Inflammatory Bowel Disease

Autor: Fernando Gomollón, Petr Ricanek, Gwo-Tzer Ho, Nicholas A. Kennedy, Simen Vatn, Nicholas T. Ventham, S McTaggart, Rahul Kalla, Daniel Bergemalm, Jan Krzysztof Nowak, C Clarke, B Lopez-Jimena, Alasdair Ivens, Jørgen Jahnsen, Morten H. Vatn, Jack Satsangi, Amy H. Buck, Johan D. Söderholm, Ruby White, Alex Adams, Jonas Halfvarson

Publikováno v: Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
2020, ' Whole blood profiling of T-cell derived miRNA allows the development of prognostic models in inflammatory bowel disease ', Journal of Crohn's and Colitis, vol. 14, no. 12, pp. 1724–1733 . https://doi.org/10.1093/ecco-jcc/jjaa134

Background MicroRNAs [miRNAs] are cell-specific small non-coding RNAs that can regulate gene expression and have been implicated in inflammatory bowel disease [IBD] pathogenesis. Here we define the cell-specific miRNA profiles and investigate its bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb631f85394eba488e1ce1c6ddc27dba
https://doi.org/10.1093/ecco-jcc/jjaa134