Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Johan Broddefalk"'
Autor:
Punit P. Seth, Johan Broddefalk, Patrik U. Andersson, Johan Meuller, Michael E. Østergaard, Thazha P. Prakash, Linda Sundström, Leonardo De Maria, Wuxia Fu, Ahlke Hayen, David Janzén, Carina Ämmälä, Eric Valeur, Laurent Knerr, Maria Ölwegård-Halvarsson, Richard G. Lee, Shalini Andersson, William J. Drury, Elaine Pirie, Mehran Nikan, Rasmus Jansson-Löfmark
Publikováno v:
Journal of the American Chemical Society. 143:3416-3429
The extra hepatic delivery of antisense oligonucleotides (ASOs) remains a challenge and hampers the widespread application of this powerful class of therapeutic agents. In that regard, pancreatic beta cells are a particularly attractive but challengi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b854feb4ca478194b8ccb06db2a2c928
https://doi.org/10.1021/jacs.0c12043
https://doi.org/10.1021/jacs.0c12043
Autor:
Hans Ericsson, Igor L. Shamovsky, Carl Whatling, Malin Lemurell, Marianne Swanson, Eva-Lotte Lindstedt, Johan Broddefalk, Mats Någård, Anita Dellsén, Johan Ulander, Carl Amilon, Kenneth Granberg, Annika Westin Eriksson, Daniel Pettersen, Alleyn T. Plowright, Monica Sundqvist, Hans Emtenäs, Martin A. Hayes
Publikováno v:
Journal of Medicinal Chemistry. 62:4312-4324
5-Lipoxygenase activating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway activity and reduce the production of proinflammatory and vasoactive leukotrienes. As such, they are hypothesized to have therapeutic benefit for the treatment of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f5cbb07e77468dbbb61f1fcb001052
https://doi.org/10.1021/acs.jmedchem.8b02004
https://doi.org/10.1021/acs.jmedchem.8b02004
Autor:
Tomas Akerud, Hannah de la Motte, Eva Hurt-Camejo, Tim D. J. Perkins, Åsa Månsson, Frank Jansen, Hans-Georg Beisel, Mikael Dahlström, Gabrielle Saarinen, Fabrizio Giordanetto, Robert G. Roth, Marie Ahlqvist, Fredrik Klingegård, Birgitta Rosengren, Laurent Knerr, Kenth Hallberg, Ingemar Starke, Jenny Sandmark, Daniel Pettersen, Nidhal Selmi, Margareta Herslöf, Johan Brengdahl, Tommy Olsson, Mattias Rohman, Peter Nordberg, Johan Broddefalk
Publikováno v:
ACS Medicinal Chemistry Letters. 9:594-599
[Image: see text] In order to assess the potential of sPLA(2)-X as a therapeutic target for atherosclerosis, novel sPLA(2) inhibitors with improved type X selectivity are required. To achieve the objective of identifying such compounds, we embarked o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3062a7d8619a16b010f0164ff18f98cf
https://doi.org/10.1021/acsmedchemlett.7b00505
https://doi.org/10.1021/acsmedchemlett.7b00505
Autor:
Peter R. Moore, Hans Emtenäs, Andrew Stark, Johan Broddefalk, Staffan Karlsson, Rolf Bergman, Christian Löfberg
Publikováno v:
Organic Process Research & Development. 22:618-624
A large-scale, robust telescoped process involving acid chloride generation and Friedel–Crafts acylation followed by hydrolysis of an ester was developed for the manufacture of a homochiral disubstituted cyclohexane. Chromatography was avoided, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83e28764604100dd0596271543752ce9
https://doi.org/10.1021/acs.oprd.8b00066
https://doi.org/10.1021/acs.oprd.8b00066
Autor:
Christian Löfberg, Marianne Swanson, ZhongQing Yuan, Johan Broddefalk, Annika Westin Eriksson, Susanne Winiwarter, Martin A. Hayes, Gabrielle Saarinen, Johan Meuller, Carl Whatling, Johan Ulander, Hans Emtenäs, Johan Cassel, Monica Sundqvist, Malin Lemurell, Luna Prieto Garcia, Staffan Karlsson
Publikováno v:
Journal of medicinal chemistry. 62(9)
5-Lipoxygenase (5-LO)-activating protein (FLAP) inhibitors have proven to attenuate 5-LO pathway activity and leukotriene production in human clinical trials. However, previous clinical candidates have been discontinued and the link between FLAP inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff40a6805c4be041ac624c15aa826045
https://pubmed.ncbi.nlm.nih.gov/30929436
https://pubmed.ncbi.nlm.nih.gov/30929436
Autor:
Johannes Wikström, Johan Brengdahl, Hanna De La Motte, Hans Georg Beisel, Maria Wågberg, Robert G. Roth, Mikael Dahlström, Nidhal Selmi, Gabrielle Saarinen, Daniel Pettersen, Fabrizio Giordanetto, Eva Hurt-Camejo, Åsa Månsson, Frank Jansen, Mattias Rohman, Laurent Knerr, Fredrik Klingegård, Birgitta Rosengren, Marie Ahlqvist, Tomas Akerud, Jenny Sandmark, Johan Broddefalk, Peter Nordberg
[Image: see text] A lead generation campaign identified indole-based sPLA(2)-X inhibitors with a promising selectivity profile against other sPLA(2) isoforms. Further optimization of sPLA(2) selectivity and metabolic stability resulted in the design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5426bebf6e544cdf4fd5b3f245895890
https://europepmc.org/articles/PMC6047026/
https://europepmc.org/articles/PMC6047026/
Autor:
Wei Zhongyong, Johan Broddefalk, Madeleine Antonsson, Kosrat Amin, Jörgen Jensen, Johan Ulander, Maxime Tremblay, Stephane St-Onge, Karolina Nilsson, Shujuan Jin, Anders Lehmann, Alleyn T. Plowright, Christopher Walpole, Tomaszewski Miroslaw, Hua Yang
Publikováno v:
Journal of Medicinal Chemistry. 56:220-240
Agonists of the cannabinoid receptor 1 (CB1) have been suggested as possible treatments for a range of medical disorders including gastroesophageal reflux disease (GERD). While centrally acting cannabinoid agonists are known to produce psychotropic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e05819466ec51f70ae07e9321387a5
https://doi.org/10.1021/jm301511h
https://doi.org/10.1021/jm301511h
Autor:
Susanne Winiwarter, Öjvind Davidsson, Alleyn T. Plowright, Anna Pettersen, Carl Whatling, Marie Rydén-Landergren, Johan Broddefalk, Margareta Herslöf, Jonas Gunnar Barlind, Daniel Hovdal, Kalle Sigfridsson, Tomas Drmota, Marianne Swanson, Hans Emtenäs, Antonio Llinas, Sara Moses, Johan Ulander, Anders Dahlén, Malin Lemurell
Publikováno v:
Journal of medicinal chemistry. 58(2)
A drug discovery program in search of novel 5-lipoxygenase activating protein (FLAP) inhibitors focused on driving a reduction in lipophilicity with maintained or increased ligand lipophilic efficiency (LLE) compared to previously reported compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d45db613ea0bfe337b948d40f96b41
https://pubmed.ncbi.nlm.nih.gov/25478788
https://pubmed.ncbi.nlm.nih.gov/25478788
Publikováno v:
Tetrahedron. 56:1579-1586
Different protective groups for (5R)-5-hydroxy-L-lysine were investigated in silver silicate promoted glycosylations with aceto-bromogalactose as glycosyl donor. Best results were obtained with Fmo ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2764bcbca8fe409f3fa1ce2f62ad85
https://doi.org/10.1016/s0040-4020(00)00061-2
https://doi.org/10.1016/s0040-4020(00)00061-2
Publikováno v:
Tetrahedron. 54:12047-12070
β-D-Galactopyranosyl and α-D-glucopyranosyl-β-D-galactopyranosyl moieties carrying silyl, isopropylidene and 4-methoxybenzyl protective groups have been attached to the amino acid 5-hydroxy-L-norvaline. The resulting glycosylated building blocks w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::853c25e89cdb300a5cf9de686a956317
https://doi.org/10.1016/s0040-4020(98)83057-3
https://doi.org/10.1016/s0040-4020(98)83057-3