Expanding the CRISPR toolbox for Chinese hamster ovary cells with comprehensive tools for Mad7 genome editing

Autor: Johan B. Rojek, Yogesh Basavaraju, Saranya Nallapareddy, Dubhe B. Bulté, Roland Baumgartner, Sanne Schoffelen, Lise M. Grav, Steffen Goletz, Lasse E. Pedersen

Publikováno v: Rojek, J B, Basavaraju, Y, Nallapareddy, S, Ocaña, D B B, Baumgartner, R, Schoffelen, S, Grav, L M, Goletz, S & Pedersen, L E 2023, ' Expanding the CRISPR toolbox for Chinese hamster ovary cells with comprehensive tools for Mad7 genome editing ', Biotechnology and Bioengineering, vol. 120, no. 6, pp. 1478-1491 . https://doi.org/10.1002/bit.28367

The production of high-value biopharmaceuticals is dominated by mammalian production cells, particularly Chinese Hamster Ovary (CHO) cells, which have been widely used and preferred in manufacturing processes. The discovery of CRISPR-Cas9 significant

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https://doi.org/10.1002/bit.28367