Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Johan Aarum"'
Autor:
Ioanna Smyrlaki, Martin Ekman, Antonio Lentini, Nuno Rufino de Sousa, Natali Papanicolaou, Martin Vondracek, Johan Aarum, Hamzah Safari, Shaman Muradrasoli, Antonio Gigliotti Rothfuchs, Jan Albert, Björn Högberg, Björn Reinius
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
SARS-CoV-2 infection is widely diagnosed by RT-PCR, but RNA extraction is a bottleneck for fast and cheap diagnosis. Here, the authors develop protocols to perform RT-PCR directly on heat-inactivated subject samples or samples lysed with readily avai
Externí odkaz:
https://doaj.org/article/1fdca452b94243fe9b1c96011a64ebaf
Autor:
Rocco Adiutori, Johan Aarum, Irene Zubiri, Michael Bremang, Stephan Jung, Denise Sheer, Ian Pike, Andrea Malaspina
Publikováno v:
Biochemistry and Biophysics Reports, Vol 14, Iss C, Pp 168-177 (2018)
Protein aggregation in biofluids is a poorly understood phenomenon. Under normal physiological conditions, fluid-borne aggregates may contain plasma or cell proteins prone to aggregation. Recent observations suggest that neurofilaments (Nf), the buil
Externí odkaz:
https://doaj.org/article/1f3a8a229be74ec8a921b8141a1b1678
Autor:
Tania A Jones, Babatunji W Ogunkolade, Jaroslaw Szary, Johan Aarum, Muhammad A Mumin, Shyam Patel, Christopher A Pieri, Denise Sheer
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22399 (2011)
BORIS (CTCFL) is the paralog of CTCF (CCCTC-binding factor; NM_006565), a ubiquitously expressed DNA-binding protein with diverse roles in gene expression and chromatin organisation. BORIS and CTCF have virtually identical zinc finger domains, yet di
Externí odkaz:
https://doaj.org/article/d036b88b361b4ab183d6f47a2d1f9300
Autor:
Denise Sheer, Andrea Malaspina, Fabiola Puentes, Irene Zubiri, Ian Pike, Simon McArthur, Rocco Adiutori, Michael Bremang, Emanuela Leoni, Vittoria Lombardi, Johan Aarum
Publikováno v:
Brain Communications
Plasma proteome composition reflects the inflammatory and metabolic state of the organism and can be predictive of system-level and organ-specific pathologies. Circulating protein aggregates are enriched with neurofilament heavy chain—axonal protei
Autor:
Johan Aarum, Shiron Rajendran, Andrea Malaspina, Gavin Giovannoni, Claudia P. Cabrera, Tania A. Jones, Rocco Adiutori, Denise Sheer, Michael R. Barnes
Publikováno v:
EMBO Reports
Most proteins in cell and tissue lysates are soluble. We show here that in lysate from human neurons, more than 1,300 proteins are maintained in a soluble and functional state by association with endogenous RNA, as degradation of RNA invariably leads
Autor:
Andrea Malaspina, Rocco Adiutori, Johan Aarum, Denise Sheer, Irene Zubiri, Emanuela Leoni, Michael Bremang, Vittoria Lombardi, Simon McArthur, Ian Pike, Fabiola Puentes
Background: plasma proteins composition reflects the inflammatory and metabolic state of an organism and can be predictive of system-level and organ-specific pathologies. Circulating protein aggregates (CPA) are enriched with heavy chain neurofilamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee4029f6514a42e4c0042cd8b20364f
https://doi.org/10.21203/rs.3.rs-71596/v1
https://doi.org/10.21203/rs.3.rs-71596/v1
Autor:
Antonio Lentini, Björn Reinius, Hamzah Safari, Ioanna Smyrlaki, Antonio Gigliotti Rothfuchs, Björn Högberg, Shaman Muradrasoli, Johan Aarum, Jan Albert, Nuno Rufino de Sousa, Natali Papanicolaou, Martin Ekman, Martin Vondracek
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is commonly diagnosed by reverse transcription polymerase chain reaction (RT-PCR) to detect viral RNA in patient samples, but RNA extraction
Autor:
Michael Bremang, Irene Zubiri, Denise Sheer, Rocco Adiutori, Andrea Malaspina, Stephan Jung, Johan Aarum, Ian Pike
Publikováno v:
Biochemistry and Biophysics Reports, Vol 14, Iss C, Pp 168-177 (2018)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Protein aggregation in biofluids is a poorly understood phenomenon. Under normal physiological conditions, fluid-borne aggregates may contain plasma or cell proteins prone to aggregation. Recent observations suggest that neurofilaments (Nf), the buil
Autor:
Babatunji W Ogunkolade, Shihong Mao, Christopher A. Pieri, Johan Aarum, Jaroslaw Szary, Stephen A. Krawetz, Tania A. Jones, Diego Ottaviani, Muhammad A. Mumin, Elliott Lever, Denise Sheer, Rossitza Christova
Publikováno v:
Nucleic Acids Research
Activation of the major histocompatibility complex (MHC) by interferon-gamma (IFN-γ) is a fundamental step in the adaptive immune response to pathogens. Here, we show that reorganization of chromatin loop domains in the MHC is evident within the fir
Autor:
Konstantinos Meletis, Maggie S. Y. Yeung, Magda Forsberg, Jonas Frisén, Mats A. A. Persson, Fanie Barnabé-Heider, Marie Carlén, Johan Aarum
Publikováno v:
Proceedings of the National Academy of Sciences. 107:14657-14661
Neural stem cells have a broad differentiation repertoire during embryonic development and can be reprogrammed to pluripotency comparatively easily. We report that adult neural stem cells can be reprogrammed at very high efficiency to monocytes, a di