Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Johan A. Kers"'
Autor:
Johan A. Kers, Robert E. Sharp, Anthony W. Defusco, Jae H. Park, Jin Xu, Mark E. Pulse, William J. Weiss, Martin Handfield
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Lantibiotics offer an untapped pipeline for the development of novel antibiotics to treat serious Gram-positive (+) infections including Clostridium difficile. Mutacin 1140 (MU1140) is a lantibiotic produced by Streptococcus mutans and acts via a nov
Externí odkaz:
https://doaj.org/article/b817fd7f62a14cda95a6d257a5f10e9a
Autor:
N. V. Rajeshkumar, Martin Handfield, Johan A. Kers, Jae H. Park, Scott Moncrief, Anthony W. Defusco
Publikováno v:
Toxicology and Applied Pharmacology. 374:32-40
Clostridium difficile associated disease (CDAD) is the leading infectious cause of antibiotic-associated diarrhea and colitis in the United States. Both the incidence and severity of CDAD have been increased over the past two decades. We evaluated th
Autor:
Martin Handfield, Jae H. Park, Mark Pulse, William J. Weiss, Anthony W. Defusco, Johan A. Kers
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Lantibiotics present an attractive scaffold for the development of novel antibiotics. We report here a novel lantibiotic for the treatment of Clostridium difficile infection. The lead compounds were selected from a library of over 700 single- and mul
Autor:
Anthony W. Defusco, Robert Eryl Sharp, Jin Xu, Jae H. Park, Martin Handfield, William J. Weiss, Mark Pulse, Johan A. Kers
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Frontiers in Microbiology
Frontiers in Microbiology
Lantibiotics offer an untapped pipeline for the development of novel antibiotics to treat serious Gram-positive (+) infections including Clostridium difficile. Mutacin 1140 (MU1140) is a lantibiotic produced by Streptococcus mutans and acts via a nov
Autor:
Johan A. Kers, Sheela Muley, Jeffrey Colbeck, Melissa Mayo, R. Eryl Sharp, Jae H. Park, Anthony W. Defusco, Yihui Zhu, Martin Handfield
Publikováno v:
Chemical biologydrug design. 92(6)
Lantibiotics represent a large untapped pipeline of attractive scaffolds for the development of novel antibiotics. Saturation mutagenesis was employed to substitute every amino acid of a lantibiotic called mutacin 1140 (MU1140), creating an unbiased
OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infections
Autor:
Martin Handfield, Jae H. Park, Johan A. Kers, William J. Weiss, Jin Xu, Anthony W. Defusco, Mark Pulse
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197467 (2018)
Lantibiotics continue to offer an untapped pipeline for the development of novel antibiotics. We report here the discovery of a novel lantibiotic for the treatment of C. difficile infection (CDI). The leads were selected from a library of over 300 mu
Autor:
Johan A. Kers, R. Eryl Sharp, Sheela Muley, Melissa Mayo, Jeffrey Colbeck, Yihui Zhu, Anthony W. DeFusco, Jae H. Park, Martin Handfield
Publikováno v:
Chemical Biology & Drug Design. 92:i-i
Publikováno v:
Nitric Oxide. 12:46-53
Evidence for the involvement of a bacterial nitric oxide synthase (NOS) in the biosynthesis of a phytotoxin is presented. Several species of Streptomyces bacteria produce secondary metabolites with unusual nitrogen groups, such as thaxtomin A (ThxA),
Autor:
Raghida Bukhalid, Donna M. Gibson, Kimberly D. Cameron, Rosemary Loria, Joanne E. Morello, Johan A. Kers, Madhumita V. Joshi, Michael J. Wach
Publikováno v:
Molecular Microbiology. 55:1025-1033
Potato scab is a globally important disease caused by polyphyletic plant pathogenic Streptomyces species. Streptomyces acidiscabies, Streptomyces scabies and Streptomyces turgidiscabies possess a conserved biosynthetic pathway for the nitrated dipept
Autor:
Kimberly D. Cameron, Rosemary Loria, Joanne Widom, Michael J. Wach, Johan A. Kers, Donna M. Gibson, Raghida Bukhalid, Brian R. Crane, Stuart B. Krasnoff
Publikováno v:
Nature. 429:79-82
Nitric oxide (NO) is a potent intercellular signal in mammals that mediates key aspects of blood pressure, hormone release, nerve transmission and the immune response of higher organisms. Proteins homologous to full-length mammalian nitric oxide synt