Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Johan Åqvist"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Enzymes from organisms inhabiting cold environments (psychrophiles) have adapted to catalyzing chemical reactions at near freezing temperatures. Here – using molecular dynamics simulations – the authors analyze cold adaptation of psychrophilic α
Externí odkaz:
https://doaj.org/article/884691212e474ae6a75d5ebf6a689783
Autor:
Willem Jespers, Laura H Heitman, Adriaan P IJzerman, Eddy Sotelo, Gerard J P van Westen, Johan Åqvist, Hugo Gutiérrez-de-Terán
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1009152 (2021)
Transmembranal G Protein-Coupled Receptors (GPCRs) transduce extracellular chemical signals to the cell, via conformational change from a resting (inactive) to an active (canonically bound to a G-protein) conformation. Receptor activation is normally
Externí odkaz:
https://doaj.org/article/ed5e77758ad342f7b032db580b22f1c5
Publikováno v:
ACS Omega, Vol 4, Iss 13, Pp 15539-15548 (2019)
Externí odkaz:
https://doaj.org/article/a9c9e93f22dd4567ab89bb4f3c51602f
Publikováno v:
Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-16 (2019)
Abstract The process of ligand binding to a biological target can be represented as the equilibrium between the relevant solvated and bound states of the ligand. This which is the basis of structure-based, rigorous methods such as the estimation of r
Externí odkaz:
https://doaj.org/article/0fdb0109a1ba4d81a05fe86958fbb923
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Inhibition of the insulin-regulated aminopeptidase (IRAP) improves memory and cognition in animal models. The enzyme has recently been crystallized and several series of inhibitors reported. We herein focused on one series of benzopyran-based inhibit
Externí odkaz:
https://doaj.org/article/6982a429a01f4ea1ac17c4c894c3ae7a
Autor:
Xiaohu Guo, Annika Söderholm, Sandesh Kanchugal P, Geir V Isaksen, Omar Warsi, Ulrich Eckhard, Silvia Trigüis, Adolf Gogoll, Jon Jerlström-Hultqvist, Johan Åqvist, Dan I Andersson, Maria Selmer
Publikováno v:
eLife, Vol 10 (2021)
The first S-adenosyl methionine (SAM) degrading enzyme (SAMase) was discovered in bacteriophage T3, as a counter-defense against the bacterial restriction-modification system, and annotated as a SAM hydrolase forming 5’-methyl-thioadenosine (MTA) a
Externí odkaz:
https://doaj.org/article/525d1cf985e947098fe9b6f370a1c8f9
Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides
Autor:
Sudarsana Reddy Vanga, Jonas Sävmarker, Leelee Ng, Mats Larhed, Mathias Hallberg, Johan Åqvist, Anders Hallberg, Siew Yeen Chai, Hugo Gutiérrez-de-Terán
Publikováno v:
ACS Omega, Vol 3, Iss 4, Pp 4509-4521 (2018)
Externí odkaz:
https://doaj.org/article/bfde87a0178d46798e868c6357b43391
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
The eukaryotic release factor eRF1 is able to recognize the three stop codons UAA, UAG and UGA with high accuracy, while discriminating against near-cognate codons. Here the authors use molecular dynamic simulation to provide insight into the molecul
Externí odkaz:
https://doaj.org/article/433a1ca0112148518b78c6acfcf20c96
Autor:
Anne Cathrine Nøhr, Willem Jespers, Mohamed A. Shehata, Leonard Floryan, Vignir Isberg, Kirsten Bayer Andersen, Johan Åqvist, Hugo Gutiérrez-de-Terán, Hans Bräuner-Osborne, David E. Gloriam
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract GPR139 is an orphan G protein-coupled receptor expressed in the brain, in particular in the habenula, hypothalamus and striatum. It has therefore been suggested that GPR139 is a possible target for metabolic disorders and Parkinson’s disea
Externí odkaz:
https://doaj.org/article/17e7b959f6554066a99116d9312ac208
Autor:
Silvana Vasile, Anders Hallberg, Jessica Sallander, Mathias Hallberg, Johan Åqvist, Hugo Gutiérrez-de-Terán
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 649 (2020)
Angiotensin II receptor type 1 and 2 (AT1R and AT2R) are two G-protein coupled receptors that mediate most biological functions of the octapeptide Angiotensin II (Ang II). AT2R is upregulated upon tissue damage and its activation by selective AT2R ag
Externí odkaz:
https://doaj.org/article/409d868369ea4f3fabdf7e0d5112eaf4