Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Johan, Staaf"'
Autor:
Suze Roostee, Daniel Ehinger, Mats Jönsson, Bengt Phung, Göran Jönsson, Gottfrid Sjödahl, Johan Staaf, Mattias Aine
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The tumour immune microenvironment (TIME) in breast cancer is acknowledged with an increasing role in treatment response and prognosis. With a growing number of immune markers analysed, digital image analysis may facilitate broader TIME unde
Externí odkaz:
https://doaj.org/article/329b5205029c49d09097eb1d2393861b
Autor:
Srinivas Veerla, Johan Staaf
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Kataegis is a hypermutation phenomenon characterized by localized clusters of single base pair substitution (SBS) reported in multiple cancer types. Despite a high frequency in breast cancer, large-scale analyses of kataegis patterns and ass
Externí odkaz:
https://doaj.org/article/f96353864b7a434f99ab3ded4b9a7b83
Autor:
Völundur Hafstað, Jari Häkkinen, Malin Larsson, Johan Staaf, Johan Vallon-Christersson, Helena Persson
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Genomic rearrangements in cancer cells can create fusion genes that encode chimeric proteins or alter the expression of coding and non-coding RNAs. In some cancer types, fusions involving specific kinases are used as targets for t
Externí odkaz:
https://doaj.org/article/9ff2da0262514696b39df8415e9a8fba
Autor:
Benedetta Conte, Fara Brasó-Maristany, Adela Rodríguez Hernández, Tomás Pascual, Guillermo Villacampa, Francesco Schettini, Maria J. Vidal Losada, Elia Seguí, Laura Angelats, Isabel Garcia-Fructuoso, Raquel Gómez-Bravo, Natàlia Lorman-Carbó, Laia Paré, Mercedes Marín-Aguilera, Olga Martínez-Sáez, Barbara Adamo, Esther Sanfeliu, Beatrice Fratini, Claudette Falato, Núria Chic, Ana Vivancos, Patricia Villagrasa, Johan Staaf, Joel S. Parker, Charles M. Perou, Aleix Prat
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105043- (2024)
Summary: Background: Early-stage triple-negative breast cancer (TNBC) displays clinical and biological diversity. From a biological standpoint, immune infiltration plays a crucial role in TNBC prognosis. Currently, there is a lack of genomic tools ai
Externí odkaz:
https://doaj.org/article/e280cec22ed2498189d321ebd159a946
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract PAM50 gene expression subtypes represent a cornerstone in the molecular classification of breast cancer and are included in risk prediction models to guide therapy. We aimed to illustrate the impact of included genes and biological processes
Externí odkaz:
https://doaj.org/article/afe69700fcb64a0e87092685206f1280
Autor:
Gudbjörg Sigurjonsdottir, Tommaso De Marchi, Anna Ehinger, Johan Hartman, Ana Bosch, Johan Staaf, Fredrika Killander, Emma Niméus
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background Immunohistochemical (IHC) PD-L1 expression is commonly employed as predictive biomarker for checkpoint inhibitors in triple-negative breast cancer (TNBC). However, IHC evaluation methods are non-uniform and further studies are nee
Externí odkaz:
https://doaj.org/article/a009212643f448b9bbced5c2d5101159
Autor:
Deborah F. Nacer, Johan Vallon-Christersson, Nicklas Nordborg, Hans Ehrencrona, Anders Kvist, Åke Borg, Johan Staaf
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-20 (2023)
Abstract Background Pathogenic germline variants (PGVs) in certain genes are linked to higher lifetime risk of developing breast cancer and can influence preventive surgery decisions and therapy choices. Public health programs offer genetic screening
Externí odkaz:
https://doaj.org/article/c8bd8024118d4cae9d57089d992fec03
Autor:
Jiajin Chen, Yunjie Song, Yi Li, Yongyue Wei, Sipeng Shen, Yang Zhao, Dongfang You, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, Hongbing Shen, David C. Christiani, Ruyang Zhang, Feng Chen
Publikováno v:
Molecular Oncology, Vol 17, Iss 1, Pp 173-187 (2023)
Epigenome‐wide gene–gene (G × G) interactions associated with non‐small‐cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three‐step analytic strategy to identify
Externí odkaz:
https://doaj.org/article/fefc809c9bc94dd2bd4f3ace96ece64c
Autor:
Johan Staaf, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Siker Kimbung, Ingrid Hedenfalk, Tonje Lien, Therese Sørlie, Bjørn Naume, Hege Russnes, Rachel Marcone, Ayyakkannu Ayyanan, Cathrin Brisken, Rebecka R. Malterling, Bengt Asking, Helena Olofsson, Henrik Lindman, Pär-Ola Bendahl, Anna Ehinger, Christer Larsson, Niklas Loman, Lisa Rydén, Martin Malmberg, Åke Borg, Johan Vallon-Christersson
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, subtypes, and risk of recurrence (
Externí odkaz:
https://doaj.org/article/d2e56c524d0b4a448d746df4499518bd
Autor:
Xinyu Ji, Lijuan Lin, Juanjuan Fan, Yi Li, Yongyue Wei, Sipeng Shen, Li Su, Andrea Shafer, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, Ruyang Zhang, Feng Chen, David C. Christiani
Publikováno v:
Molecular Oncology, Vol 16, Iss 3, Pp 717-731 (2022)
The interaction between DNA methylation of tripartite motif containing 27 (cg05293407TRIM27) and smoking has previously been identified to reveal histologically heterogeneous effects of TRIM27 DNA methylation on early‐stage non‐small‐cell lung
Externí odkaz:
https://doaj.org/article/f987d620e07840b28fadb06cb458f7d7