Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Johan, Heldin"'
Autor:
Doroteya Raykova, Despoina Kermpatsou, Tony Malmqvist, Philip J. Harrison, Marie Rubin Sander, Christiane Stiller, Johan Heldin, Mattias Leino, Sara Ricardo, Anna Klemm, Leonor David, Ola Spjuth, Kalyani Vemuri, Anna Dimberg, Anders Sundqvist, Maria Norlin, Axel Klaesson, Caroline Kampf, Ola Söderberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Determining the levels of protein–protein interactions is essential for the analysis of signaling within the cell, characterization of mutation effects, protein function and activation in health and disease, among others. Herein, we descri
Externí odkaz:
https://doaj.org/article/62ebc0c6a0da437aba3d465a5bbe05c2
Autor:
Doroteya Raykova, Despoina Kermpatsou, Tony Malmqvist, Philip J. Harrison, Marie Rubin Sander, Christiane Stiller, Johan Heldin, Mattias Leino, Sara Ricardo, Anna Klemm, Leonor David, Ola Spjuth, Kalyani Vemuri, Anna Dimberg, Anders Sundqvist, Maria Norlin, Axel Klaesson, Caroline Kampf, Ola Söderberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/1b52ed4d7464442c978e7ac4bff1d6a2
Autor:
Peter Lönn, Rasel A. Al-Amin, Ehsan Manouchehri Doulabi, Johan Heldin, Radiosa Gallini, Johan Björkesten, Johan Oelrich, Masood Kamali-Moghaddam, Ulf Landegren
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
To improve our ability to monitor cellular responses to e.g. cytokines or drugs, Lönn et al have developed a semi-automated system for large-scale in situ proximity ligation assays (isPLA) in HaCAT keratinocyte cells. Their approach expands the scop
Externí odkaz:
https://doaj.org/article/e5ecdbaa06634e1d97b74de9458d189e
Autor:
Axel Klaesson, Karin Grannas, Tonge Ebai, Johan Heldin, Björn Koos, Mattias Leino, Doroteya Raykova, Johan Oelrich, Linda Arngården, Ola Söderberg, Ulf Landegren
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract We have redesigned probes for in situ proximity ligation assay (PLA), resulting in more efficient localized detection of target proteins. In situ PLA depends on recognition of target proteins by pairs of antibody-oligonucleotide conjugates (
Externí odkaz:
https://doaj.org/article/75ad5875c3544fa48fd0da457da9bb4f
The interplay between membrane subregions and receptor tyrosine kinases (RTK) will influence signaling in both normal and pathological RTK conditions. In this study, epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636bc6419c62bab23df924d024ca3de3
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506912
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506912
Autor:
Camille Ternet, Philipp Junk, Thomas Sevrin, Simona Catozzi, Erik Wåhlén, Johan Heldin, Giorgio Oliviero, Kieran Wynne, Christina Kiel
Publikováno v:
Life Science Alliance. 6:e202201670
Ras is a key switch controlling cell behavior. In the GTP-bound form, Ras interacts with numerous effectors in a mutually exclusive manner, where individual Ras–effectors are likely part of larger cellular (sub)complexes. The molecular details of t
Publikováno v:
Cellular Signalling. 98:110411
Autor:
Bjoern Koos, Ola Söderberg, Johan Heldin, Mattias Leino, Marie Rubin Sander, Despoina Kermpatsou, Doroteya Raykova
Publikováno v:
Molecular Systems Design & Engineering. 4:1058-1065
Proximity based detection methods are invaluable tools in the field of molecular biology, increasing selectivity and allowing for analysis of protein interactions. ProxHCR utilizes pairs of antibodies labelled with oligonucleotides to probe for proxi
Autor:
Felipe Marques Souza de Oliveira, Benjamin Siart, Celso A. Reis, Karol Polom, Johan Heldin, Masood Kamali-Moghaddam, Stefan Mereiter, Niclas G. Karlsson, Doroteya Raykova, Franco Roviello, Qiujin Shen, Peter Lönn
Publikováno v:
New Biotechnology. 45:51-59
Post-translational modifications (PTMs) regulate protein activities to help orchestrate and fine-tune cellular processes. Dysregulation of PTMs is often related with disorders and malignancies, and may serve as a precise biomarker of disease. Develop
Autor:
Masood Kamali-Moghaddam, Rasel A. Al-Amin, Ehsan Manouchehri Doulabi, Johan Björkesten, Peter Lönn, Johan Heldin, Radiosa Gallini, Ulf Landegren, Johan Oelrich
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology
Communications Biology
Protein interactions and posttranslational modifications orchestrate cellular responses to e.g. cytokines and drugs, but it has been difficult to monitor these dynamic events in high-throughput. Here, we describe a semi-automated system for large-sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8fa2e1a506a5e0a72143f491041a88
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459770
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459770