Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist

Autor: Minka Zivkovic, Elisabeth Pols - van Veen, Vossa van der Vegte, Silvie A.E. Sebastian, Annick S. de Moor, Suzanne J.A. Korporaal, Roger E.G. Schutgens, Rolf T. Urbanus, Erik Beckers, Michiel Coppens, Jeroen Eikenboom, Louise Hooimeijer, Gerard Jansen, Roger Schutgens, Rolf Urbanus, Emile van den Akker, Wala Al Arashi, Ryanne Arisz, Lieke Baas, Ruben Bierings, Maartje van den Biggelaar, Johan Boender, Anske van der Bom, Mettine Bos, Martijn Brands, Annelien Bredenoord, Laura Bukkems, Lex Burdorf, Jessica Del Castillo Alferez, Michael Cloesmeijer, Marjon Cnossen, Mariëtte Driessens, Karin Fijnvandraat, Kathelijn Fischer, Geertje Goedhart, Tine Goedhart, Samantha Gouw, Rieke van der Graaf, Masja de Haas, Lotte Haverman, Jan Hazelzet, Shannon van Hoorn, Elise Huisman, Nathalie Jansen, Alexander Janssen, Sean de Jong, Sjoerd Koopman, Marieke Kruip, Sebastiaan Laan, Frank Leebeek, Nikki van Leeuwen, Hester Lingsma, Moniek de Maat, Ron Mathôt, Felix van der Meer, Karina Meijer, Sander Meijer, Stephan Meijer, Iris van Moort, Caroline Mussert, Hans Kristian Ploos van Amstel, Suzanne Polinder, Diaz Prameyllawati, Simone Reitsma, Eliza Roest, Lorenzo Romano, Saskia Schols, Carin Uyl, Jan Voorberg, Huan Zhang

Publikováno v: Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 7, Pp 102582- (2024)

Background: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders. GPVI can be activat

Externí odkaz: https://doaj.org/article/0ff9e6640dac449daeff9b624d1422ef

von Willebrand factor and factor VIII levels after desmopressin are associated with bleeding phenotype in type 1 VWD

Autor: Ferdows Atiq, Lisette M. Schütte, Agnes E.M. Looijen, Johan Boender, Marjon H. Cnossen, Jeroen Eikenboom, Moniek P.M. de Maat, Marieke J. H.A. Kruip, Frank W.G. Leebeek

Publikováno v: Blood Advances, Vol 3, Iss 24, Pp 4147-4154 (2019)

Abstract: The bleeding phenotype of patients with type 1 von Willebrand disease (VWD) is very heterogeneous. We hypothesized that this heterogeneity may partly be explained by variability in response of von Willebrand factor (VWF) and factor VIII (FV

Externí odkaz: https://doaj.org/article/44d5b678927a485e9f11a0735d0e127e

SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders

Autor: Marjon H. Cnossen, Iris van Moort, Simone H. Reitsma, Moniek P.M. de Maat, Roger E.G. Schutgens, Rolf T. Urbanus, Hester F. Lingsma, Ron A.A. Mathot, Samantha C. Gouw, Karina Meijer, Annelien L. Bredenoord, Rieke van der Graaf, Karin Fijnvandraat, Alexander B. Meijer, Emile van den Akker, Ruben Bierings, Jeroen C.J. Eikenboom, Maartje van den Biggelaar, Masja de Haas, Jan Voorberg, Frank W.G. Leebeek, Ryanne A. Arisz, Minka Zivkovic, E. Shannon van Hoorn, Laura H. Bukkems, Tine M.C.H.J. Goedhart, Lorenzo G.R. Romano, Wala Al Arashi, Michael E. Cloesmeijer, Alexander Janssen, Martijn R. Brands, Lieke Baas, Jessica del Castillo Alferez, Huan Zhang, Sebastiaan N.J. Laan, Johan Boender, Johanna G. van der Bom, Mettine H.A. Bos, Lex Burdorf, Michiel Coppens, Mariette Driessens, Kathelijne F. Fischer, Lotte Haverman, Jan A. Hazelzet, Elise J. Huisman, Natalie Jansen, Sean de Jong, Marieke Kruip, Nikki van Leeuwen, Felix van der Meer, Stephan Meijer, Hans Kristian Ploos van Amstel, Suzanne Polinder, Saskia E.M. Schols, Guus Wijfjes, Kees Kluft, Waander L. van Heerde, Geertje Goedhart, Carin Uyl, Jasmijn Timp, Anke Stekelenburg, Floor Moenen, Paula Ypma, Laurens Nieuwenhuizen, Arnoud Plat

Publikováno v: Journal of Thrombosis and Haemostasis, 20(9), 2001-2011. Wiley
Journal of Thrombosis and Haemostasis, 20(9), 2001-2011. Wiley-Blackwell
Journal of thrombosis and haemostasis, 20(9), 2001-2011. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 20(9), 2001-2011. WILEY
Journal of Thrombosis and Haemostasis, 20(9), 2001-2011. Wiley-Blackwell Publishing Ltd
SYMPHONY consortium 2022, ' SYMPHONY consortium : Orchestrating personalized treatment for patients with bleeding disorders ', Journal of Thrombosis and Haemostasis, vol. 20, no. 9, pp. 2001-2011 . https://doi.org/10.1111/jth.15778

Background: Treatment choices for individual patients with an inborn bleeding disorder are increasingly challenging due to increasing options and rising costs for society. We have initiated an integrated interdisciplinary national research program. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f106600596b9764406a2984249fa8169
https://hdl.handle.net/1887/3494538

ADAMTS-13 and bleeding phenotype in von Willebrand disease

Autor: Johan Boender, Angelique Nederlof, Karina Meijer, Evelien P. Mauser‐Bunschoten, Marjon H. Cnossen, Karin Fijnvandraat, Johanna G. van der Bom, Joke de Meris, Britta A.P. Laros‐van Gorkom, Karin P.M. van Galen, Jeroen Eikenboom, Moniek P.M de Maat, Frank W.G. Leebeek, M. Coppens, L. Nieuwenhuizen, R.Y.J. Tamminga, P.F. Ypma, F.J.W. Smiers, E. Beckers, P. Brons, F. Atiq

Publikováno v: Research and Practice in Thrombosis and Haemostasis, 4(8), 1331-1339. WILEY
Research and Practice in Thrombosis and Haemostasis, 4, 8, pp. 1331-1339
Research and Practice in Thrombosis and Haemostasis
Research and practice in thrombosis and haemostasis, 1331-1339. Wiley
ISSUE=8;STARTPAGE=1331;ENDPAGE=1339;ISSN=2475-0379;TITLE=Research and practice in thrombosis and haemostasis
Research and Practice in Thrombosis and Haemostasis, 4, 1331-1339
Research and Practice in Thrombosis and Haemostasis, 4(8), 1331-1339. Wiley-Blackwell Publishing Ltd
Research and practice in thrombosis and haemostasis, 4(8), 1331-1339. Wiley-Blackwell Publishing Ltd

Contains fulltext : 229340.pdf (Publisher’s version ) (Open Access) BACKGROUND: The bleeding phenotype of von Willebrand disease (VWD) varies highly between patients and can only partly be explained by von Willebrand factor (VWF) parameters. By cle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff40f9c491c1ed385ec82015ceaa4f03
http://hdl.handle.net/1887/3184730

Semiautomatic VWF Multimer Densitometric Analysis: Validation of the Clinical Accuracy and Clinical Implications in Von Willebrand Disease

Autor: Johan Boender, Britta A P Laros-van Gorkom, Marjon H. Cnossen, Jeroen Eikenboom, Johanna G. van der Bom, Karina Meijer, Joke de Meris, Karin Fijnvandraat, Karin P M van Galen, Frank W.G. Leebeek, Moniek P.M. de Maat, Ferdows Atiq

Publikováno v: Blood. 136:15-16

Introduction Von Willebrand factor (VWF) multimer analysis is an essential tool in the diagnosis and classification of von Willebrand disease (VWD). Current visual VWF multimer analysis is observer dependent, time consuming and is inaccurate in detec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15da207f5d7e62ffb708cd104a757ee8
https://doi.org/10.1182/blood-2020-142287