Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Joh-E. Ikeda"'
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186227 (2017)
Therapeutic agents to the central nervous system (CNS) need to be efficiently delivered to the target site of action at appropriate therapeutic levels. However, a limited number of effective drugs for the treatment of neurological diseases has been d
Externí odkaz:
https://doaj.org/article/53ab403282df4af99e80368a39a39563
Autor:
Eiichiro Nagata, Mieko Ogino, Kounosuke Iwamoto, Yasuhisa Kitagawa, Yasuo Iwasaki, Fumihito Yoshii, Joh-E Ikeda, ALS Consortium Investigators
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149509 (2016)
OBJECTIVE:Bromocriptine mesylate (BRC), a dopamine D2 receptor agonist has been shown to confer neuroprotection, sustained motor function and slowed disease progression in mouse models of amyotrophic lateral sclerosis (ALS) Here we report a first in
Externí odkaz:
https://doaj.org/article/0f5ffb727004459ea391bc0ee4c2b3bb
Autor:
Eiichiro Nagata, Mieko Ogino, Kounosuke Iwamoto, Yasuhisa Kitagawa, Yasuo Iwasaki, Fumihito Yoshii, Joh-E Ikeda, ALS Consortium Investigators
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152845 (2016)
Externí odkaz:
https://doaj.org/article/2bb17bd36410428e863617890c9ddd5b
Autor:
Kazunori Tanaka, Takuya Kanno, Yoshiko Yanagisawa, Kaori Yasutake, Satoshi Inoue, Noriaki Hirayama, Joh-E Ikeda
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87728 (2014)
Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron degenerative disease. Given that oxidative stress and resulting chronic neuronal inflammation are thought to be central pathogenic, anti-oxidative agents and modulators of neuronal in
Externí odkaz:
https://doaj.org/article/42da0d67f6444d5f9c1db3e0aa957082
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
The delineation of the molecular pathology underlying amyotrophic lateral sclerosis (ALS) is being hampered by the lack of suitable biomarkers. We have previously reported that bromocriptine upregulates the endogenous antioxidative factor, neuronal a
Autor:
Shinji Hadano, Asako Otomo, Ryota Kunita, Kyoko Suzuki-Utsunomiya, Akira Akatsuka, Masato Koike, Masashi Aoki, Yasuo Uchiyama, Yasuto Itoyama, Joh-E Ikeda
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9805 (2010)
ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involved in macropinocytosis-associated endosome fusion and trafficking, and neurite outgrowth. ALS2 deficiency accounts for a number of juvenile recessive motor neuron
Externí odkaz:
https://doaj.org/article/2cf745a0edfb46929bf1461ffa1e9c1a
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186227 (2017)
PLoS ONE
PLoS ONE
Therapeutic agents to the central nervous system (CNS) need to be efficiently delivered to the target site of action at appropriate therapeutic levels. However, a limited number of effective drugs for the treatment of neurological diseases has been d
Autor:
Shinji Hadano, Kaori Yasutake, Fumihito Yoshii, Joh-E Ikeda, Yoshiko Yanagisawa, Noriaki Hirayama, Kazunori Tanaka, Takuya Kanno
Publikováno v:
Free Radical Biology and Medicine. 53:2028-2042
Antioxidant defense is crucial in restoring cellular redox homeostasis. Recent findings have suggested that oxidative stress plays pivotal roles in the pathogenesis of many neurodegenerative diseases. Thus, an anti-oxidative stress remedy might be a
Autor:
Mieko Ogino, Yasuhisa Kitagawa, Eiichiro Nagata, Fumihito Yoshii, Yasuo Iwasaki, Kounosuke Iwamoto, Joh-E Ikeda
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149509 (2016)
PLoS ONE
PLoS ONE
OBJECTIVE:Bromocriptine mesylate (BRC), a dopamine D2 receptor agonist has been shown to confer neuroprotection, sustained motor function and slowed disease progression in mouse models of amyotrophic lateral sclerosis (ALS) Here we report a first in
Autor:
Fumihito Yoshii, Shinji Hadano, Kaori Yasutake, Yoshiko Yanagisawa, Takuya Kanno, Kazunori Tanaka, Joh-E Ikeda
Publikováno v:
Experimental Neurology. 232:41-52
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Since oxidative stress plays a crucial role in the progression of motor neuron loss observed in ALS, a