A Mass Spectrometric Characterization of Light-Induced Modifications in Therapeutic Proteins.

Autor: Zhang Z; Process Development, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: zzhang@amgen.com., Chow SY; Process Development, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320, USA., De Guzman R; Process Development, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320, USA., Joh NH; Process Development, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320, USA., Joubert MK; Process Development, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320, USA., Richardson J; Process Development, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320, USA., Shah B; Process Development, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320, USA., Wikström M; Process Development, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320, USA., Zhou ZS; Department of Chemistry and Chemical Biology, Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, MA 02115, USA., Wypych J; Process Development, Amgen Inc. One Amgen Center Drive, Thousand Oaks, CA 91320, USA.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2022 Jun; Vol. 111 (6), pp. 1556-1564. Date of Electronic Publication: 2022 Feb 12.

Silicone Oil Particles in Prefilled Syringes With Human Monoclonal Antibody, Representative of Real-World Drug Products, Did Not Increase Immunogenicity in In Vivo and In Vitro Model Systems.

Autor: Joh NH; Amgen Inc., Thousand Oaks, California 91320. Electronic address: nate.joh@amgen.com., Thomas L; Amgen Inc., Thousand Oaks, California 91320., Christian TR; Amgen Inc., Thousand Oaks, California 91320., Verlinsky A; Amgen Inc., Thousand Oaks, California 91320., Jiao N; Amgen Inc., Thousand Oaks, California 91320., Allotta N; Amgen Inc., Thousand Oaks, California 91320., Jawa V; Amgen Inc., Thousand Oaks, California 91320., Cao S; Amgen Inc., Thousand Oaks, California 91320., Narhi LO; Amgen Inc., Thousand Oaks, California 91320., Joubert MK; Amgen Inc., Thousand Oaks, California 91320. Electronic address: mjoubert@amgen.com.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2020 Jan; Vol. 109 (1), pp. 845-853. Date of Electronic Publication: 2019 Oct 16.

Impact of Precipitation of Antibody Therapeutics After Subcutaneous Injection on Pharmacokinetics and Immunogenicity.

Autor: Kinderman F; Drug Product Technologies, Amgen Inc, Thousand Oaks, California 91320. Electronic address: francisk@amgen.com., Yerby B; Research Imaging Sciences, Amgen Inc, Thousand Oaks, California 91320., Jawa V; Predictive and Clinical Immunogenicity, Merck Sharp and Dohme Corp, Kenilworth, New Jersey 07033., Joubert MK; Attribute Sciences, Amgen Inc, Thousand Oaks, California 91320., Joh NH; Attribute Sciences, Amgen Inc, Thousand Oaks, California 91320., Malella J; Pharmacokinetics and Drug Metabolism, Amgen Inc, Thousand Oaks, California 91320., Herskovitz J; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198., Xie J; Medical Sciences, Amgen Inc, Thousand Oaks, California 91320., Ferbas J; Medical Sciences, Amgen Inc, Thousand Oaks, California 91320., McBride HJ; Biosimilars Business Unit, Amgen Inc, Thousand Oaks, California 91320.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2019 Jun; Vol. 108 (6), pp. 1953-1963. Date of Electronic Publication: 2019 Jan 23.

De novo design of a transmembrane Zn²⁺-transporting four-helix bundle.

Autor: Joh NH; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Wang T; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bhate MP; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Acharya R; School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha, India., Wu Y; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Grabe M; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA. william.degrado@ucsf.edu gevorg.grigoryan@dartmouth.edu meihong@mit.edu michael.grabe@ucsf.edu., Hong M; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. william.degrado@ucsf.edu gevorg.grigoryan@dartmouth.edu meihong@mit.edu michael.grabe@ucsf.edu., Grigoryan G; Department of Computer Science and Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA. william.degrado@ucsf.edu gevorg.grigoryan@dartmouth.edu meihong@mit.edu michael.grabe@ucsf.edu., DeGrado WF; Department of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA. william.degrado@ucsf.edu gevorg.grigoryan@dartmouth.edu meihong@mit.edu michael.grabe@ucsf.edu.

Publikováno v: Science (New York, N.Y.) [Science] 2014 Dec 19; Vol. 346 (6216), pp. 1520-4.

Structural imperatives impose diverse evolutionary constraints on helical membrane proteins.

Autor: Oberai A; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA., Joh NH, Pettit FK, Bowie JU

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2009 Oct 20; Vol. 106 (42), pp. 17747-50. Date of Electronic Publication: 2009 Oct 06.