Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Joginder S. Bajwa"'
Autor:
Joginder S. Bajwa, Xinglong Jiang, Huaimin Wang, Jianbiao Peng, Zhongbo Fei, Weiyong Kong, Feng Sun, Yueyan Yin
Publikováno v:
Organic Process Research & Development. 16:1436-1441
A short and scalable synthesis of chiral hydroxamic acid 1, a LpxC inhibitor, is described. This work discloses a novel diastereoselective addition of 2-nitropropane-generated lithium salt to tert-...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d79d4d1f54e9cd6ff8afd63f6893aa2c
https://doi.org/10.1021/op300163n
https://doi.org/10.1021/op300163n
Autor:
Guang-Pei Chen, Hui Liu, Calienni John Vincent, David Thomas Parker, Edwin Bernard Villhauer, Thomas J. Blacklock, Oljan Repic, Joginder S. Bajwa, Vivelo James Anthony, Joel Slade, Kapa Prasad
Publikováno v:
Organic Process Research & Development. 11:825-835
An efficient synthesis of a potent insulin-like growth factor I receptor (IGF-IR) inhibitor AEW541 (1) is described. The key step in the synthesis is the cis-selective reductive amination of cyclobutanone, which sets up the desired 1,3-stereochemistr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8680a9e056f9ffa4fdd95136e5c721f6
https://doi.org/10.1021/op700052u
https://doi.org/10.1021/op700052u
Autor:
Karl Dean, Apurva Chaudhary, Dana Wambser, Oljan Repic, Martin Mueller, Hui Liu, Joginder S. Bajwa, Helmut Boehnke, Kathryn Rene Bracken, Paul G. Lee, Thomas J. Blacklock, Vivelo James Anthony, Joseph Carosi, Kapa Prasad, Michael J. Girgis, Joel Slade, Guang-Pei Chen, David Thomas Parker
Publikováno v:
Organic Process Research & Development. 10:78-93
A practical synthesis of the peptide deformylase inhibitor LBM415, (2S)-N-(5-fluoro-1-oxido-2-pyridinyl)-1-[(2R)-2-[(formylhydroxyamino)methyl]-1-oxohexyl]-2-pyrrolidinecarboxamide, magnesium salt 11, is described. The key chiral intermediate, (2S)-N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::235d589a0750f7d99f4094c42ae298b3
https://doi.org/10.1021/op050165y
https://doi.org/10.1021/op050165y
Autor:
Michael J. Girgis, David Thomas Parker, Parker David John, Joginder S. Bajwa, Hui Liu, Oljan Repic, Joel Slade, Thomas J. Blacklock, Vivelo James Anthony
Publikováno v:
Organic Process Research & Development. 9:608-620
A practical 9-step synthesis of the dual matrix metalloprotease/tumor necrosis factor inhibitor MMP090, trans-(R)-[[N-(4-ethoxyphenylsulfonyl)-N-(4-pyridinylmethyl)]amino]-N-hydroxy-4-propoxy cyclohexaneacetamide 10, was accomplished in 12% overall y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e7b5f41692ea0178d06de135825474
https://doi.org/10.1021/op050066k
https://doi.org/10.1021/op050066k
Publikováno v:
Tetrahedron Letters. 41:6025-6028
Catalytic transfer hydrogenation using 10% Pd–C in the presence of 1,4-cyclohexadiene as the hydrogen donor selectively debenzylates amines and reduces carbon–carbon double bonds while leaving benzyl and benzyloxymethyl ethers intact.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ecab9b81a73dd00178a32542f074dc9
https://doi.org/10.1016/s0040-4039(00)01013-3
https://doi.org/10.1016/s0040-4039(00)01013-3
Publikováno v:
Tetrahedron Letters. 41:6021-6024
Alkyl t -butyldimethylsilyl ethers can be selectively cleaved in the presence of aryl ethers using a catalytic amount of bismuth bromide in wet acetonitrile at ambient temperatures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b56c60f7522570ba4f0a5460d701ab28
https://doi.org/10.1016/s0040-4039(00)01012-1
https://doi.org/10.1016/s0040-4039(00)01012-1
Publikováno v:
Tetrahedron Letters. 47:6425-6427
A very mild, efficient, and convenient method for deprotection of N-tosylated indoles and related structures by cesium carbonate in THF–MeOH is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a5a810d98676257c5189c183500bd3
https://doi.org/10.1016/j.tetlet.2006.06.132
https://doi.org/10.1016/j.tetlet.2006.06.132
Publikováno v:
Tetrahedron Letters. 43:9225-9227
A novel method for preparing ethers from alkoxydialkylsilanes and carbonyl compounds through reductive etherification is described. The salient feature in this method is the utilization of internal hydrogen as the hydride source for reducing the oxon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ec72e1e0128f9ba088890c08a5cc19
https://doi.org/10.1016/s0040-4039(02)02253-0
https://doi.org/10.1016/s0040-4039(02)02253-0
Autor:
Joginder S. Bajwa, Robert C. Anderson
Publikováno v:
ChemInform. 23
Lithium halides in the presence of an acid (pKa < 13) react with epoxides regioselectively to give vicinal halohydrins in high yields The simplicity and convenience of this procedure makes it attractive for large scale synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::032c0a23d8b3943ce934cda5d0eb3000
https://doi.org/10.1002/chin.199214100
https://doi.org/10.1002/chin.199214100