Single-cell RNA sequencing identifies senescence as therapeutic target in rhabdomyolysis-induced acute kidney injury.

Autor: Rao SN; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Zahm M; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291-CNRS UMR5051-Université Paul Sabatier (UPS), Toulouse, France., Casemayou A; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Buleon M; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Faguer S; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France.; Department of Nephrology and Organ Transplantation, Referral Centre for Rare Kidney Diseases, French Intensive Care Renal Network, University Hospital of Toulouse, Toulouse, France., Feuillet G; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Iacovoni JS; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Joffre OP; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291-CNRS UMR5051-Université Paul Sabatier (UPS), Toulouse, France., Gonzalez-Fuentes I; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Lhuillier E; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Martins F; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Riant E; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Zakaroff-Girard A; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Schanstra JP; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Saulnier-Blache JS; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Belliere J; Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France.; Department of Nephrology and Organ Transplantation, Referral Centre for Rare Kidney Diseases, French Intensive Care Renal Network, University Hospital of Toulouse, Toulouse, France.

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2024 Feb 28; Vol. 39 (3), pp. 496-509.

IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4 ⁺ Foxp3 ⁺ regulatory T lymphocytes.

Autor: Apert C; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Galindo-Albarrán AO; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France.; Station d'Ecologie Théorique et Expérimentale, CNRS, Moulis, France., Castan S; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Detraves C; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Michaud H; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., McJannett N; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Haegeman B; Station d'Ecologie Théorique et Expérimentale, CNRS, Moulis, France., Fillatreau S; Institut Necker Enfants Malades, Inserm U1151, CNRS UMR8253, Paris, France.; Université de Paris Descartes, Faculté de Médecine, Paris, France.; AP-HP, Hôpital Necker-Enfants Malades, Paris, France., Malissen B; Centre d'Immunophénomique (CIPHE), Aix Marseille Université, INSERM, CNRS, Marseille, France., Holländer G; Paediatric Immunology, Department of Biomedicine, University of Basel and University Children's Hospital Basel, Basel, Switzerland.; Department of Paediatrics and the Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.; Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland., Žuklys S; Paediatric Immunology, Department of Biomedicine, University of Basel and University Children's Hospital Basel, Basel, Switzerland., Santamaria JC; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Joffre OP; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., Romagnoli P; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France., van Meerwijk JPM; Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291 - CNRS UMR5051 - University Toulouse III, Toulouse, France.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Sep 08; Vol. 13, pp. 965303. Date of Electronic Publication: 2022 Sep 08 (Print Publication: 2022).

Robust intrathymic development of regulatory T cells in young NOD mice is rapidly restrained by recirculating cells.

Autor: Darrigues J; Centre de Physiopathologie Toulouse Purpan (CPTP), Inserm U1043, CNRS UMR 5282, Université de Toulouse III (UPS), Toulouse, France., Santamaria JC; Centre de Physiopathologie Toulouse Purpan (CPTP), Inserm U1043, CNRS UMR 5282, Université de Toulouse III (UPS), Toulouse, France., Galindo-Albarrán A; Centre de Physiopathologie Toulouse Purpan (CPTP), Inserm U1043, CNRS UMR 5282, Université de Toulouse III (UPS), Toulouse, France.; Station d'Ecologie Théorique et Expérimentale, CNRS, Moulis, France, Université Paul Sabatier, Moulis, France., Robey EA; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA., Joffre OP; Centre de Physiopathologie Toulouse Purpan (CPTP), Inserm U1043, CNRS UMR 5282, Université de Toulouse III (UPS), Toulouse, France., van Meerwijk JPM; Centre de Physiopathologie Toulouse Purpan (CPTP), Inserm U1043, CNRS UMR 5282, Université de Toulouse III (UPS), Toulouse, France., Romagnoli P; Centre de Physiopathologie Toulouse Purpan (CPTP), Inserm U1043, CNRS UMR 5282, Université de Toulouse III (UPS), Toulouse, France.

Publikováno v: European journal of immunology [Eur J Immunol] 2021 Mar; Vol. 51 (3), pp. 580-593. Date of Electronic Publication: 2020 Aug 13.

Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors.

Autor: Thiault N; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France., Darrigues J; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France., Adoue V; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France., Gros M; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France. [4] Ecole Normale Supérieure de Lyon, Department of Biology, 69007 Lyon, France., Binet B; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France., Perals C; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France., Leobon B; Department of Pediatric Cardiology and Cardiovascular surgery, Children Hospital, University Hospital of Toulouse, Toulouse, France., Fazilleau N; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France., Joffre OP; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France., Robey EA; Department of Molecular and Cell Biology, Division of Immunology and Pathogenesis, University of California, Berkeley, California, USA., van Meerwijk JP; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France., Romagnoli P; 1] Institut National de la Santé et de la Recherche Médicale U1043, Toulouse, France. [2] Centre National de la Recherche Scientifique U5282, Toulouse, France. [3] Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.

Publikováno v: Nature immunology [Nat Immunol] 2015 Jun; Vol. 16 (6), pp. 628-34. Date of Electronic Publication: 2015 May 04.

Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.

Autor: Joffre OP; Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, London, UK., Sancho D, Zelenay S, Keller AM, Reis e Sousa C

Publikováno v: European journal of immunology [Eur J Immunol] 2010 May; Vol. 40 (5), pp. 1255-65.