Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joey Orpilla"'
Autor:
Alexander H. Lee, Lu Sun, Aaron Y. Mochizuki, Jeremy G. Reynoso, Joey Orpilla, Frances Chow, Jenny C. Kienzler, Richard G. Everson, David A. Nathanson, Steven J. Bensinger, Linda M. Liau, Timothy Cloughesy, Willy Hugo, Robert M. Prins
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Immune-checkpoint blockade has shown limited benefits in patients with glioblastoma. To understand how the composition of the tumor immune microenvironment might limit clinical responses, here the authors present a high dimensional profiling of the i
Externí odkaz:
https://doaj.org/article/bc4276916a1e42c19b71f6a03a3eba26
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Supplementary Figure 3: Gene expression analysis shows increased transcription of activation and exhaustion genes in the PD-1+ population in glioma TILs and of antigen experienced genes in the PD-1+ population in glioma PBMCs (each dot represents a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dde78b81dc465a1fa300e2da7231211
https://doi.org/10.1158/1078-0432.22471280
https://doi.org/10.1158/1078-0432.22471280
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Supplementary Table 1: Panel of CyTOF markers used in our study and how each marker was classified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a859c349ad7a82a703bad70e55bb2d1
https://doi.org/10.1158/1078-0432.22471277.v1
https://doi.org/10.1158/1078-0432.22471277.v1
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Purpose:Glioblastoma (GBM) is the most common primary malignant tumor in the central nervous system. Our recent preclinical work has suggested that PD-1/PD-L1 plays an important immunoregulatory role to limit effective antitumor T-cell responses indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b405b9d3ab6a83cb2eb931617679f7
https://doi.org/10.1158/1078-0432.c.6527837.v1
https://doi.org/10.1158/1078-0432.c.6527837.v1
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Supplementary Figure 1: T cells from GBM patient TILs show highest expression of PD-1 compared to healthy donor PBMC and GBM patient PBMCs A) A representative flow cytometry plot measuring PD-1+ expression on CD4+ and CD8+ T cells from Healthy Donor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a71858d7ce51fa1fc8f4761b150acac
https://doi.org/10.1158/1078-0432.22471286
https://doi.org/10.1158/1078-0432.22471286
Autor:
Robert M. Prins, Christel Herold-Mende, Linda M. Liau, Timothy F. Cloughesy, William H. Yong, Richard Everson, Anthony Wang, David Nathanson, Nicholas Bayless, Nikesh Kotecha, Alejandro Garcia, Joseph Antonios, Aaron Mochizuki, Mildred Galvez, Carmen Rapp, Saskia Roesch, Max Mastall, Janet Treger, Joey Orpilla, Shaina Sedighim, Melody Hsu, Alexander Lee, Tom B. Davidson
Supplementary Figure 2: Additional CyTOF data A) The percentage of the CD3+ PD-1+ cells from the TIL (green dots) and PBMCs (red dots) in each cluster (*P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f7bb31ecfe60aeeeaa6a83c799334a
https://doi.org/10.1158/1078-0432.22471283
https://doi.org/10.1158/1078-0432.22471283
Autor:
Francesco Sanvito, Catalina Raymond, Nicholas S Cho, Akifumi Hagiwara, Joey Orpilla, Noriko Salamon, Timothy Cloughesy, Linda M Liau, Richard G Everson, Phioanh L Nghiemphu, Albert Lai, Robert Prins, Benjamin Ellingson
Publikováno v:
Neuro-Oncology. 24:vii174-vii174
BACKGROUND In a classic DSC perfusion sequence, T1 and T2* leakage effects compete in determining the post-bolus signal, and are influenced by tissue geometry (i.e. cell density, cell size). Different DSC sequences can be variously influenced by thes
Autor:
Anthony C Wang, Geoffrey Owens, Alexander Lee, Matthew Z Sun, Sophie Peeters, Jenny C Kienzler, Joey Orpilla, Erick Contreras, Janet Treger, Sylvia K Odesa, Richard G Everson, Eric C Holland, Oren Becher, David Nathanson, Yi Xing, Linda M Liau, Robert M Prins
Publikováno v:
Neurosurgery. 67
Autor:
Sophie Peeters, Geoffrey Owens, Matthew Z Sun, Alexander Lee, Jenny C Kienzler, Joey Orpilla, Erick Contreras, Janet Treger, Silvia Odesa, Richard G Everson, Oren Becher, Eric C Holland, David Nathanson, Yi Xing, Linda M Liau, Robert M Prins, Anthony C Wang
Publikováno v:
Neurosurgery. 67
Autor:
Andres M. Salazar, Richard Everson, Timothy F. Cloughesy, Joey Orpilla, Joseph Antonios, Carolina Chavez, Linda M. Liau, Alexander Lee, Robert M. Prins, Lu Sun, Sara Khattab, Willy Hugo
Publikováno v:
Neuro Oncol
Despite recent advances with immunotherapy in other tumor types, malignant glioma patients have not shown a therapeutic benefit, potentially due to the insufficient activation of an immune response. We and others have documented immune responses and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4a0b68c25706b5a5e56108ca522c3d
https://europepmc.org/articles/PMC7650313/
https://europepmc.org/articles/PMC7650313/