The age of randomized clinical trials: three important aspects of randomized clinical trials in cardiovascular pharmacotherapy with examples from lipid, diabetes, and antithrombotic trials

Autor: AnneGrete Semb, Joern F Dopheide, Juan Tamargo, Stuart J. Pocock, Juan Carlos Kaski, Heinz Drexel, Sven Wassmann, Thomas Andersen Schmidt, Arthur Mader, Keld Kjeldsen, Alexander Niessner, Gianluigi Savarese, Stefan Agewall, Basil S. Lewis, Christoph H. Saely, Kurt Huber, Giuseppe M.C. Rosano, Gerda Tautermann

Publikováno v: Drexel, H, Lewis, B S, Rosano, G M C, Saely, C H, Tautermann, G, Huber, K, Dopheide, J F, Kaski, J C, Mader, A, Niessner, A, Savarese, G, Schmidt, T A, Semb, A, Tamargo, J, Wassmann, S, Kjeldsen, K P, Agewall, S & Pocock, S J 2021, ' The age of randomized clinical trials : three important aspects of randomized clinical trials in cardiovascular pharmacotherapy with examples from lipid, diabetes, and antithrombotic trials ', European Heart Journal-Cardiovascular Pharmacotherapy, vol. 7, no. 5, pp. 453–459 . https://doi.org/10.1093/ehjcvp/pvaa126

This review article aims to explain the important issues that data safety monitoring boards (DSMB) face when considering early termination of a trial and is specifically addressed to the needs of clinical and research cardiologists. We give an insigh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce05db94f871ce17aa1218a4cc63c61
https://doi.org/10.1093/ehjcvp/pvaa126

Subgroup analyses in randomized clinical trials:value and limitations. Review #3 on important aspects of randomized clinical trials in cardiovascular pharmacotherapy

Autor: Basil S. Lewis, Martin Clodi, Juan Carlos Kaski, Alexander Niessner, Stefan Agewall, Giuseppe M.C. Rosano, Stuart J. Pocock, Heinz Drexel, Christoph H. Saely, Anne Grete Semb, Gianluigi Savarese, Gerda Tautermann, Kurt Huber, Juan Tamargo, Joern F Dopheide, Arthur Mader, Thomas Andersen Schmidt, Sven Wassmann, Keld Kjeldsen

Publikováno v: Drexel, H, Pocock, S J, Lewis, B S, Saely, C H, Kaski, J C, Rosano, G M C, Tautermann, G, Huber, K, Dopheide, J F, Mader, A, Niessner, A, Savarese, G, Schmidt, T A, Semb, A G, Tamargo, J, Wassmann, S, Clodi, M, Kjeldsen, K P & Agewall, S 2022, ' Subgroup analyses in randomized clinical trials : value and limitations. Review #3 on important aspects of randomized clinical trials in cardiovascular pharmacotherapy ', European Heart Journal-Cardiovascular Pharmacotherapy, vol. 8, no. 3, pp. 302-310 . https://doi.org/10.1093/ehjcvp/pvab048
Drexel, H, Pocock, S J, Lewis, B S, Saely, C H, Kaski, J C, Rosano, G M C, Tautermann, G, Huber, K, Dopheide, J F, Mader, A, Niessner, A, Savarese, G, Schmidt, T A, Semb, A G, Tamargo, J, Wassmann, S, Clodi, M, Kjeldsen, K P & Agewall, S 2022, ' Subgroup analyses in randomized clinical trials : Value and limitations Review #3 on important aspects of randomized clinical trials in cardiovascular pharmacotherapy ', European Heart Journal-Cardiovascular Pharmacotherapy, vol. 8, no. 3, pp. 302-310 . https://doi.org/10.1093/ehjcvp/pvab048

Two review articles previously published from our working group were dedicated to the selection of endpoints as well as to reasons for premature stopping of randomized clinical trials (RCTs).1,2 We there first discussed the importance of mortality an

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https://curis.ku.dk/ws/files/359860634/444088146.pdf

Prognostic role of polyvascular involvement in patients with symptomatic peripheral artery disease

Autor: Luise Adam, Joern F Dopheide, Iris Baumgartner, M Khorrami Borozadi, Heinz Drexel, Mathias Kaspar

Background Patients with peripheral artery disease (PAD) are at very high risk of future cardiovascular events. However, clinical experience suggests that PAD has a wide range of prognosis due to a different atherosclerotic extent with further vascul

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Differentiation of Monocyte Derived Dendritic Cells in End Stage Renal Disease is Skewed Towards Accelerated Maturation

Autor: Joern F. Dopheide, Urban Sester, Martin K. Kuhlmann, Geraldine C. Zeller, Martina Sester, Matthias Girndt

Publikováno v: Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 24(2)

Background. Dendritic cells (DC) play an important role in the induction of immune responses. Patients with end stage renal disease (ESRD) suffer from chronic inflammation, leading to a secondary, uremic immunodeficiency associated with alterations i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08be836d6807a13e8c04898c3dfe0d68
https://pubmed.ncbi.nlm.nih.gov/25931358

Whole Blood of Patients with Peripheral Arterial Disease Shows an Increased Production of Reactive Oxygen Species and a Proinflammatory Phenotype

Autor: Christopher Doppler, Viviane Obst, Thomas Münzel, Andreas Daiber, Joern F Dopheide, Ascan Warnholtz, Christine Espinola-Klein, Marie-Christine Radmacher, Tommaso Gori

Publikováno v: Biophysical Journal. 102(3)

We investigated the production of reactive oxygen species (ROS) in whole blood of patients with peripheral arterial disease (PAD) and performed a phenotypic characterisation of peripheral blood monocytes and dendritic cells (DC) in comparison to heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198771be3ec5388394b1fb538fa82ffd