Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joeri Johannes Petrus De Wit"'
Autor:
Rogier C. Buijsman, Joeri Johannes Petrus De Wit, Freek van Cauter, Michaela Tutone, Youri Adolfs, Michelle Muller, R. Jeroen Pasterkamp, Joost C.M. Uitdehaag, Mitch Hartog, Diep Vu-Pham, Nicole Willemsen-Seegers, Guido J.R. Zaman, Aletta D. Kraneveld, Antoon M. van Doornmalen, Jan Gerard Sterrenburg, Jos de Man, Paula Perez-Pardo, Yvonne Grobben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a749d11adb6b8e3b45f329232822fbcd
https://doi.org/10.1111/febs.15721/v2/response1
https://doi.org/10.1111/febs.15721/v2/response1
Autor:
Rogier C. Buijsman, Martine B.W. Prinsen, Jan Gerard Sterrenburg, Jos de Man, Joost C.M. Uitdehaag, Marion Libouban, Jeroen A.D.M. de Roos, Guido J.R. Zaman, Nicole Willemsen-Seegers, Judith R.F. de Vetter, Joeri Johannes Petrus De Wit
Publikováno v:
Journal of Molecular Biology. 429:2211-2230
The protein kinase threonine tyrosine kinase (TTK; also known as Mps1) is a critical component of the spindle assembly checkpoint and a promising drug target for the treatment of aggressive cancers, such as triple negative breast cancer. While the fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ed420d0142b2f7273d2b43a58de06e
https://doi.org/10.1016/j.jmb.2017.05.014
https://doi.org/10.1016/j.jmb.2017.05.014
Autor:
Rogier C. Buijsman, Jeroen A.D.M. de Roos, Jos de Man, Marion Libouban, Nicole Willemsen-Seegers, Joost C.M. Uitdehaag, Martine B.W. Prinsen, Joeri Johannes Petrus De Wit, Guido J.R. Zaman, Jan Gerard Sterrenburg
Publikováno v:
Cancer Research. 77:4185-4185
The protein kinase TTK is a critical component of the spindle assembly checkpoint (SAC), which regulates the proper attachment of sister chromatids during mitosis. TTK is essential for normal progression of the cell cycle and is upregulated in variou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8913be7c744f61fa27213e911a185b80
https://doi.org/10.1158/1538-7445.am2017-4185
https://doi.org/10.1158/1538-7445.am2017-4185
Autor:
Jeroen A.D.M. de Roos, Martine B.W. Prinsen, Guido J.R. Zaman, Joost C.M. Uitdehaag, Rogier C. Buijsman, Joeri Johannes Petrus De Wit, Jos de Man, Nicole Willemsen-Seegers, Jan Gerard Sterrenburg
Publikováno v:
Cancer Research. 76:2646-2646
[purpose] An abnormal number of chromosomes, or ‘aneuploidy’, is a common feature of solid human tumors and a predictor of poor prognosis in breast, lung, brain and colorectal cancer. Aneuploidy is caused by malfunctioning of the Spindle Assembly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb05a0b6db12d6e303bae26ce404954d
https://doi.org/10.1158/1538-7445.am2016-2646
https://doi.org/10.1158/1538-7445.am2016-2646
Autor:
Judith Versteegh, Joeri Johannes Petrus De Wit, Arthur Oubrie, Niels Hoogenboom, Tjeerd Barf, Maaike van Hoek, Bert Kazemier, Allard Kaptein, Carsten Schultz-Fademrecht, Paula Leandro-Garcia, Frank Wijnands, John Dulos, Martin Jaeger, Bas van de Kar, Jeroen A.D.M. de Roos, Gerard Mt Vogel, Mario van Zeeland, Edwin de Zwart, Vera de Kimpe, Judith Borsboom
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(12)
The identification of a potent, selective, and orally available MK2 inhibitor series is described. The initial absence of oral bioavailability was successfully tackled by moving the basic nitrogen of the spiro-4-piperidyl moiety towards the electron-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f22fbd250c5e4013286b26a2ff642b
https://pubmed.ncbi.nlm.nih.gov/21565498
https://pubmed.ncbi.nlm.nih.gov/21565498