Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joerg Weiske"'
Autor:
Jessica Pinkert, Hans-Henning Boehm, Mark Trautwein, Wolf-Dietrich Doecke, Florian Wessel, Yingzi Ge, Eva Maria Gutierrez, Rafael Carretero, Christoph Freiberg, Uwe Gritzan, Merlin Luetke-Eversloh, Sven Golfier, Oliver Von Ahsen, Valentina Volpin, Antonio Sorrentino, Anchana Rathinasamy, Maria Xydia, Robert Lohmayer, Julian Sax, Ayse Nur-Menevse, Abir Hussein, Slava Stamova, Georg Beckmann, Julian Marius Glueck, Dorian Schoenfeld, Joerg Weiske, Dieter Zopf, Rienk Offringa, Bertolt Kreft, Philipp Beckhove, Joerg Willuda
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a cell surface receptor, is expressed on normal epithelial tissue and highly expressed in cancers of high unmet medical need, such as non-small cell lung, pancreatic, and colorectal
Externí odkaz:
https://doaj.org/article/b51b522082204e19b3b78844000d71d5
Autor:
Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Naomi Barak, Uwe Eberspächer, Nicolas Werbeck, Carlo Stresemann, Martin Lange, Ralf Lesche, Nina Zablowsky, Katrin Juenemann, Atanas Kamburov, Laura Martina Luh, Thomas Markus Leissing, Jeremie Mortier, Michael Steckel, Holger Steuber, Knut Eis, Ashley Eheim, Patrick Steigemann
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101517- (2020)
Summary: Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions th
Externí odkaz:
https://doaj.org/article/a212af021eff409c84704cd1ec1f0308
Autor:
Ingo Hartung, Masoud Vedadi, Magda Szewczyk, Volker Badock, Carlo Stresemann, Holger Steuber, Dalia Barsyte-Lovejoy, Shawna Organ, Norbert Schmees, Clara D. Christ, Detlef Stoeckigt, Steven Kennedy, Stefan Gradl, Cheryl H. Arrowsmith, Megha Abbey, Stephan Siegel, Andrea Haegebarth, Manfred Husemann, Fengling Li, Marcus Bauser, Joerg Weiske, Irene Chau, Viacheslav V. Trush, Peter Brown
Publikováno v:
SLAS Discovery. 26:947-960
SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase that was initially described as an H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has been reported to methylate and regulate several nonhist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31088aa45c9fd48a4764afae98765927
https://doi.org/10.1177/24725552211019409
https://doi.org/10.1177/24725552211019409
Autor:
Jessica Pinkert, Hans-Henning Boehm, Mark Trautwein, Wolf-Dietrich Doecke, Florian Wessel, Yingzi Ge, Eva Maria Gutierrez, Rafael Carretero, Christoph Freiberg, Uwe Gritzan, Merlin Luetke-Eversloh, Sven Golfier, Oliver Von Ahsen, Valentina Volpin, Antonio Sorrentino, Anchana Rathinasamy, Maria Xydia, Robert Lohmayer, Julian Sax, Ayse Nur-Menevse, Abir Hussein, Slava Stamova, Georg Beckmann, Julian Marius Glueck, Dorian Schoenfeld, Joerg Weiske, Dieter Zopf, Rienk Offringa, Bertolt Kreft, Philipp Beckhove, Joerg Willuda
Publikováno v:
Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, Vol 11, Iss 1 (2022)
article-version (VoR) Version of Record
OncoImmunology, Vol 11, Iss 1 (2022)
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a cell surface receptor, is expressed on normal epithelial tissue and highly expressed in cancers of high unmet medical need, such as non-small cell lung, pancreatic, and colorectal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4287e8bd089e154a63f7b8bf72626538
https://doi.org/10.1080/2162402x.2021.2008110
https://doi.org/10.1080/2162402x.2021.2008110
Autor:
Martin Lange, Erik Schulz, Mario Huerta, Mona Blatter, Ali Nowrouzi, Bernhard Kuster, Ulrike Uhrig, Karin Laaber, Axel Benner, Hanno Glimm, Claudia R. Ball, Sina Kreth, Dominik Mumberg, Kerstin Putzker, Friederike Herbst, Joerg Weiske, Hannes Hahne, Sarah Johannes, Gerhard Siemeister, Frank Westermann, Andrea Haegebarth, Martina K. Zowada, Gabriele Stoehr, Simon Holton, Paula L Codo, Joe Lewis, Sebastian M. Dieter, Ulrike Scheib, Lena-Marit Toepper, Sylvia Martin, Christine Siegl, Anna L. Ostermann-Parucha
Summary Novel treatment options for metastatic colorectal cancer (CRC) are urgently needed to improve patient outcome. Here, we screen a library of non-characterized small molecules against a heterogeneous collection of patient-derived CRC spheroids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a410f992a87b35fec1505c6f97a79632
https://mediatum.ub.tum.de/doc/1652086/document.pdf
https://mediatum.ub.tum.de/doc/1652086/document.pdf
Autor:
Naomi Barak, Atanas Kamburov, Nina Zablowsky, Laura M. Luh, Hanna Meyer, Uwe Eberspächer, Martin Lange, Jérémie Mortier, Clara Lemos, Nico Braeuer, Thomas Markus Leissing, Patrick Steigemann, Joerg Weiske, Ralf Lesche, Michael Steckel, Holger Steuber, Carlo Stresemann, Nicolas Werbeck, Ashley Eheim, Luise Schulze, Katrin Juenemann, Knut Eis
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101517-(2020)
iScience
iScience
Summary Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccfc45a184f7faf9f0cb161ae90385f
https://pubmed.ncbi.nlm.nih.gov/32927263
https://pubmed.ncbi.nlm.nih.gov/32927263
Autor:
Franziska Siegel, Carl Friedrich Nising, Franz von Nussbaum, Ulf Boemer, Herbert Himmel, Detlev Suelzle, Marcus Bauser, Uwe Eberspaecher, Simon Holton, Joerg Weiske, Florian Prinz, Ralf Lesche, Clara Lemos, Dominik Mumberg, Dieter Moosmayer, Knut Eis, Andrea Haegebarth, Stefan Prechtl, Barbara Nicke, Duy Nguyen, Lars Wortmann, Christian Lechner, Katrin Nowak-Reppel
Publikováno v:
Journal of medicinal chemistry. 62(2)
The availability of a chemical probe to study the role of a specific domain of a protein in a concentration- and time-dependent manner is of high value. Herein, we report the identification of a highly potent and selective ERK5 inhibitor BAY-885 by h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4f7f3e30ce07bd6a816fc7f0903438
https://pubmed.ncbi.nlm.nih.gov/30563338
https://pubmed.ncbi.nlm.nih.gov/30563338
Autor:
John W. Cuozzo, Matthew A. Clark, Holly H. Soutter, Ying Zhang, Anthony D. Keefe, Vera Puetter, Hilmar Weinmann, Ingo Hartung, Detlef Stöckigt, Seong Joo Koo, Eric A. Sigel, Paolo A. Centrella, Oleg Fedorov, Simon Holton, Christoph E. Dumelin, Kilian Huber, Dawn M. Troast, Antonius Ter Laak, L. Diaz-Saez, Jan Hübner, Mátyás Gorjánácz, Volker Badock, Apirat Chaikuad, Markus Berger, Benno Kuropka, Vincent Rodeschini, James M. Bennett, Amaury Ernesto Fernandez-Montalvan, Didier M. Roche, Joerg Weiske
ATAD2 (ANCCA) is an epigenetic regulator and transcriptional cofactor, whose overexpression has been linked to the progress of various cancer types. Here, we report a DNA-encoded library screen leading to the discovery of BAY-850, a potent and isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6e59468d78b543d20e7ca9d3032de5
https://europepmc.org/articles/PMC6218015/
https://europepmc.org/articles/PMC6218015/
Autor:
Julian Glueck, Christoph Freiberg, Dieter Zopf, Hans-Henning Boehm, Heiner Apeler, Wolf-Dietrich Doecke, Florian Wessel, Joerg Weiske, Beckhove Philipp, Mark Trautwein, Ruprecht Zierz, Joerg Willuda, Sabine Wittemer-Rump, Pinkert Jessica, Ziegelbauer Karl, Uwe Gritzan, Yingzi Ge, Oliver von Ahsen, Bertolt Kreft, Gutierrez Eva-Maria, Sven Golfier, Rienk Offringa
Publikováno v:
Cancer Research. 78:1771-1771
CEACAM6 (CD66c) was previously shown to act as a novel immune checkpoint regulator suppressing the activity of effector T cells against tumors (Witzens-Harig et al., Blood 2013). CEACAM6 is a GPI-linked protein that is strongly expressed at the tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34ee3a37f29cde47828164a13773f746
https://doi.org/10.1158/1538-7445.am2018-1771
https://doi.org/10.1158/1538-7445.am2018-1771
Autor:
Clara D. Christ, Roman C. Hillig, Bernard Haendler, Hilmar Weinmann, Anke Mueller-Fahrnow, Naomi Barak, Markus Berger, Erik Eggert, Carlo Stresemann, Masoud Vedadi, Antonius Ter Laak, Stephan Siegel, Cora Scholten, Oleg Fedorov, Andrea Haegebarth, Amaury Ernesto Fernandez-Montalvan, Ursula Egner, Simon H. Holton, Peter Brown, Joerg Weiske, Mátyás Gorjánácz, Volker Badock, Ingo Hartung, Seong Joo Koo, Timo Stellfeld, Susanne Mueller, Kilian Huber, Cheryl H. Arrowsmith, Detlef Stoeckigt
Publikováno v:
Cancer Research. 77:5239-5239
Low reproducibility of published target validation studies as well as the frequent failure of genetic knock-down effects to phenocopy those of small molecule inhibitors have been recognized as road blocks for cancer drug discovery. Academic and indus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56594940be9cc1edaa3da3e7c254f327
https://doi.org/10.1158/1538-7445.am2017-5239
https://doi.org/10.1158/1538-7445.am2017-5239