Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joerg Rinnenthal"'
Autor:
Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J. Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E. Fuchs, Thomas Gerstberger, Yunhai Cui, Gabriela Gremel, Paolo Chetta, Stefan Hopf, Nicole Budano, Joerg Rinnenthal, Gerhard Gmaschitz, Moriz Mayer, Manfred Koegl, Alessio Ciulli, Harald Weinstabl, William Farnaby
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally b
Externí odkaz:
https://doaj.org/article/3f90550853c6402d8f154d10f8e2a18c
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
Supplementary Material and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820b42e67f47200c9c178cedb99c7c5a
https://doi.org/10.1158/1535-7163.22520580.v1
https://doi.org/10.1158/1535-7163.22520580.v1
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
IHC for cleaved caspase-8 and cleaved caspase-3 24h after the second administration of BI 905711 in GP2d xenograft tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334db19e87c0561dd5ecdc1dc054e314
https://doi.org/10.1158/1535-7163.22520589
https://doi.org/10.1158/1535-7163.22520589
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
S1: Evaluation of CDH17 and TRAILR2 IHC staining in hepatic metastases of colorectal cancer -S2:BI 905711 kinetic and steady-state measurements -S3: CDH17 and TRAILR2 mean fluorescence intensity, antibody binding capacity and BI 905711 / TAS266' minP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b6cd5ccfd8bf8bdf5d258d7c9e5b48
https://doi.org/10.1158/1535-7163.22520577.v1
https://doi.org/10.1158/1535-7163.22520577.v1
Autor:
Klaus Peter Kuenkele, Mark Pearson, Norbert Kraut, Frank Hilberg, Iñigo Tirapu, Maria Antonietta Impagnatiello, Craig Giragossian, Joerg Rinnenthal, Rachel Kroe-Barrett, Philip N. Gorman, Darrin Dutcher, Jason Ho, Catarina Pinto, Paolo Chetta, Andreas Wernitznig, Cordula Weishaeupl, Shirley Wang, Juan Manuel García-Martínez
Activation of TRAILR2 has emerged as an important therapeutic concept in cancer treatment. TRAILR2 agonistic molecules have only had limited clinical success, to date, due either to lack of efficacy or hepatotoxicity. BI 905711 is a novel tetravalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643c72c3613f080a868d2bc5298534ff
https://doi.org/10.1158/1535-7163.c.6542688.v1
https://doi.org/10.1158/1535-7163.c.6542688.v1
Autor:
Yvonne Scherbantin, Gerd Bader, thomas Fett, Harald Weinstabl, Sophie Mitzner, Tuncay Ciftci, Bernhard Wolkerstorfer, Jens Bruchhaus, Xiaobing Lv, Dongyang Li, Bernadette Sharps, Daniela Haering, Heribert Arnhof, Nikolai Mischerikow, Geraldine Garavel, Andreas Schrenk, Joerg Rinnenthal, Roland Kousek, Thomas Gerstberger, Guido Scholz, Stephan Karl Zahn, Paola Martinelli, Jens Quant, Renate Schnitzer, Andreas Zoephel, Darryl B. McConnell, Moriz Mayer, Dirk Kessler, Xuechun Zhang, Michelle Burkard, Mark Pearson, Karin S. Hofbauer, Alicia Du, Matthias Treu, Christoph Harrer, Yali Li, Fabio Savarese, Klaus Rumpel, Biljana Peric-Simov, Georg Dahmann, Wolfgang Sommergruber, Peter Ettmayer
Publikováno v:
Journal of Medicinal Chemistry. 62:7976-7997
Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate-limiting enzyme in the serine synthesis pathway in humans. It converts glycolysis-derived 3-phosphoglycerate to 3-phosphopyruvate in a co-factor-dependent oxidation reaction. Herein, we r
Autor:
David Covini, Christian Dank, Gerd Bader, Andreas Schrenk, Alessio Ciulli, Heribert Arnhof, Joerg Rinnenthal, Helmut Berger, Maria Rieger, Mark Pearson, Peter Greb, Jale Karolyi-Özguer, Elisabeth Traxler, Nicole Trainor, Teresa Gmaschitz, Markus Spina, Vanessa Roessler, Johannes Popow, Peter Ettmayer, Andreas Zoephel, Darryl B. McConnell, Manfred Koegl, Corinna Wieshofer, Steffen Steurer
Publikováno v:
Journal of Medicinal Chemistry. 62:2508-2520
Focal adhesion tyrosine kinase (PTK2) is often overexpressed in human hepatocellular carcinoma (HCC), and several reports have linked PTK2 depletion and/or pharmacological inhibition to reduced tumorigenicity. However, the clinical relevance of targe
Autor:
Simon Wöhrle, Tom Owen-Hughes, Jale Karolyi-Oezguer, Teresa Gmaschitz, Steffen Steurer, Bernadette Sharps, Heribert Arnhof, Gerd Bader, Joerg Rinnenthal, Thomas Gerstberger, Peter Greb, Manfred Koegl, Johannes Wachter, Michael Galant, Klaus Rumpel, Carina Riedmueller, William Farnaby, David Zollman, Peter Ettmayer, Meng-Ying Wu, Michael J. Roy, Emelyne Diers, Andreas Zoephel, Nicole Trainor, Darryl B. McConnell, Nicola Wiechens, Mark Pearson, Guido Boehmelt, Oliver Petermann, Alessio Ciulli, Renate Schnitzer, Harald Weinstabl, Christian Dank, Katharina Ehrenhöfer-Wölfer, Alexander Weiss-Puxbaum, Claire Whitworth, Elisabeth Traxler
Publikováno v:
Nature chemical biology
Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits SMARCA2 and SMARCA4 using a
Autor:
Jale Karolyi-Oezguer, Renate Schnitzer, Heribert Arnhof, Emelyne Diers, Andreas Zoephel, Harald Weinstabl, Bernadette Sharps, Darryl B. McConnell, Katharina Ehrenhöfer-Wölfer, Peter Ettmayer, David Zollman, Joerg Rinnenthal, Guido Boehmelt, Michael J. Roy, Meng-Ying Wu, Alessio Ciulli, Thomas Gerstberger, Klaus Rumpel, William Farnaby, Carina Riedmueller, Alexander Weiss-Puxbaum, Nicole Trainor, Peter Greb, Mark Pearson, Johannes Wachter, Michael Galant, Steffen Steurer, Tom Owen-Hughes, Oliver Petermann, Simon Wöhrle, Manfred Koegl, Nicola Wiechens, Elisabeth Traxler, Gerd Bader, Teresa Gmaschitz, Christian Dank, Claire Whitworth
Publikováno v:
Nature Chemical Biology. 15:846-846
In the version of this article originally published, several lines of text in the last paragraph of the right column on page 1 of the PDF were transposed into the bottom paragraph of the left column. The affected text of the left column should read "
Autor:
Joerg Rinnenthal, Juan Manuel Garcia-Martinez, Norbert Kraut, Klaus-Peter Kuenkele, Andreas Wernitznig, Mark Pearson, Craig Giragossian, Frank Hilberg, Maria Antonietta Impagnatiello
Publikováno v:
Cancer Research. 79:2051-2051
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has the capability to induce apoptosis in a wide variety of tumor cells and has emerged as an important therapeutic concept for cancer treatment. To date however, TRAILR2 agoni