Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joerg P. Burgstaller"'
Autor:
Joerg P. Burgstaller, Thomas Kolbe, Vitezslav Havlicek, Stephanie Hembach, Joanna Poulton, Jaroslav Piálek, Ralf Steinborn, Thomas Rülicke, Gottfried Brem, Nick S. Jones, Iain G. Johnston
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Mitochondrial populations in cells may consist of heteroplasmic mixtures of mtDNA types, and their evolution through development, aging and generations is central to genetic diseases. Here the authors dissect these population dynamics using a large m
Externí odkaz:
https://doaj.org/article/cc6164d489974209a000641b4844da87
Autor:
Iain G Johnston, Joerg P Burgstaller, Vitezslav Havlicek, Thomas Kolbe, Thomas Rülicke, Gottfried Brem, Jo Poulton, Nick S Jones
Publikováno v:
eLife, Vol 4 (2015)
Dangerous damage to mitochondrial DNA (mtDNA) can be ameliorated during mammalian development through a highly debated mechanism called the mtDNA bottleneck. Uncertainty surrounding this process limits our ability to address inherited mtDNA diseases.
Externí odkaz:
https://doaj.org/article/8019d712523d4708afa02fd46cc2e356
Publikováno v:
Methods in Molecular Biology ISBN: 9781071612699
Heteroplasmic mice represent a valuable tool to study the segregation of different mtDNA haplotypes (mtDNAs with differing alleles) in vivo against a defined nuclear background. We describe two methods for the creation of such models, differing in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c43bdbe08fd84934c3a8129892c8334f
https://doi.org/10.1007/978-1-0716-1270-5_6
https://doi.org/10.1007/978-1-0716-1270-5_6
Autor:
Barbara Wallner, Claus Vogl, Priyank Shukla, Joerg P Burgstaller, Thomas Druml, Gottfried Brem
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60015 (2013)
The paternally inherited Y chromosome displays the population genetic history of males. While modern domestic horses (Equus caballus) exhibit abundant diversity within maternally inherited mitochondrial DNA, no significant Y-chromosomal sequence dive
Externí odkaz:
https://doaj.org/article/bb69c0c333da43e585178eefa0aaa84c
Autor:
Iain G. Johnston, Joerg P. Burgstaller
Publikováno v:
Biochemical Society Transactions
Mitochondrial DNA (mtDNA) encodes vital respiratory machinery. Populations of mtDNA molecules exist in most eukaryotic cells, subject to replication, degradation, mutation, and other population processes. These processes affect the genetic makeup of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac9dda0d31f6988080972ad074a8a95
Autor:
Gottfried Brem, Simone Mueller, Rainer Kluger, Michal Skultety, Claus Vogl, Joerg P. Burgstaller
Publikováno v:
Journal of Orthopaedic Research. 35:894-901
Evidence for a heritable predisposition to rotator cuff tears (RCTs) is growing. Unrelated Caucasian individuals with surgically diagnosed full thickness RCTs (cases) and elderly Caucasian controls with intact rotator cuffs were screened for differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76392665240bf3fe9366c30590392521
https://doi.org/10.1002/jor.23321
https://doi.org/10.1002/jor.23321
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 39(7)
Heterogeneity in mitochondrial content has been previously suggested as a major contributor to cellular noise, with multiple studies indicating its direct involvement in biomedically important cellular phenomena. A recently published dataset explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5acab2d551dc1d35af4b40e267af267
https://pubmed.ncbi.nlm.nih.gov/28594445
https://pubmed.ncbi.nlm.nih.gov/28594445
Publikováno v:
Europe PubMed Central
STUDY QUESTION Does mitochondrial DNA (mtDNA) diversity in modern human populations potentially pose a challenge, via mtDNA segregation, to mitochondrial replacement therapies?\ud \ud SUMMARY ANSWER The magnitude of mtDNA diversity in modern human po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967c732140113246288754cd20f2dedb
https://doi.org/10.1101/072348
https://doi.org/10.1101/072348
Autor:
Thomas Kolbe, Gottfried Brem, Jo Poulton, Iain G. Johnston, Thomas Rülicke, Joerg P. Burgstaller, Vitezslav Havlicek, Nick S. Jones
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, Vol 4 (2015)
Dangerous damage to mitochondrial DNA (mtDNA) can be ameliorated during mammalian development through a highly debated mechanism called the mtDNA bottleneck. Uncertainty surrounding this process limits our ability to address inherited mtDNA diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43461a05d4a3e907b0b901f8f828705e
https://pubmed.ncbi.nlm.nih.gov/26035426
https://pubmed.ncbi.nlm.nih.gov/26035426