Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Joerg Mittelstaet"'
Autor:
Niels Werchau, Bettina Kotter, Elvira Criado-Moronati, Andre Gosselink, Nicole Cordes, Dominik Lock, Simon Lennartz, Carolin Kolbe, Nora Winter, Karin Teppert, Fabian Engert, Brian Webster, Joerg Mittelstaet, Daniel Schaefer, Peter Mallmann, Michael R. Mallmann, Dominik Ratiu, Mario Assenmacher, Thomas Schaser, Michael von Bergwelt-Baildon, Pierre Abramowski, Andrew D. Kaiser
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Solid tumors consist of malignant and nonmalignant cells that together create the local tumor microenvironment (TME). Additionally, the TME is characterized by the expression of numerous soluble factors such as TGF-β. TGF-β plays an important role
Externí odkaz:
https://doaj.org/article/c33c72814d7043f49b55860008ccb5cf
Autor:
Nicole Cordes, Nora Winter, Carolin Kolbe, Bettina Kotter, Joerg Mittelstaet, Mario Assenmacher, Toni Cathomen, Andrew Kaiser, Thomas Schaser
Publikováno v:
Viruses, Vol 14, Iss 10, p 2157 (2022)
Selective gene delivery to a cell type of interest utilizing targeted lentiviral vectors (LVs) is an efficient and safe strategy for cell and gene therapy applications, including chimeric antigen receptor (CAR)-T cell therapy. LVs pseudotyped with me
Externí odkaz:
https://doaj.org/article/eee4d9380673423ba066e75f1c54c09c
Autor:
Christian M. Seitz, Joerg Mittelstaet, Daniel Atar, Jana Hau, Selina Reiter, Clara Illi, Verena Kieble, Fabian Engert, Britta Drees, Giulia Bender, Ann-Christin Krahl, Philipp Knopf, Sarah Schroeder, Nikolas Paulsen, Alexander Rokhvarguer, Sophia Scheuermann, Elena Rapp, Anna-Sophia Mast, Armin Rabsteyn, Sabine Schleicher, Stefan Grote, Karin Schilbach, Manfred Kneilling, Bernd Pichler, Dominik Lock, Bettina Kotter, Sandra Dapa, Stefan Miltenyi, Andrew Kaiser, Peter Lang, Rupert Handgretinger, Patrick Schlegel
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Chimeric antigen receptor (CAR)-T therapy holds great promise to sustainably improve cancer treatment. However, currently, a broad applicability of CAR-T cell therapies is hampered by limited CAR-T cell versatility and tractability and the lack of ex
Externí odkaz:
https://doaj.org/article/856cb793555a4203b03dee394ed2e07f
Autor:
Stefan Grote, Joerg Mittelstaet, Caroline Baden, Kenneth Chun-Ho Chan, Christian Seitz, Patrick Schlegel, Andrew Kaiser, Rupert Handgretinger, Sabine Schleicher
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Despite the recent success of CAR T cells targeting CD19 and CD22 in hematological malignancies, the production of CAR T cells still requires an extensive manufacturing process. The well-established NK-92 cell line provides a promising alternative to
Externí odkaz:
https://doaj.org/article/0b0d562f97f048ffa69b7edf46053c85
Autor:
Bettina Kotter, Fabian Engert, Winfried Krueger, Andre Roy, Wael Al Rawashdeh, Nicole Cordes, Britta Drees, Brian Webster, Niels Werchau, Dominik Lock, Sandra Dapa, Dina Schneider, Stephan Ludwig, Claudia Rossig, Mario Assenmacher, Joerg Mittelstaet, Andrew D. Kaiser
Publikováno v:
Cancers, Vol 13, Iss 19, p 4741 (2021)
Chimeric antigen receptor (CAR) T cell therapy has emerged as an attractive strategy for cancer immunotherapy. Despite remarkable success for hematological malignancies, excessive activity and poor control of CAR T cells can result in severe adverse
Externí odkaz:
https://doaj.org/article/07057e4a21204bbf93f5df4b75d47c2f
Autor:
Stefan Grote, Frank Traub, Joerg Mittelstaet, Christian Seitz, Andrew Kaiser, Rupert Handgretinger, Sabine Schleicher
Publikováno v:
Cancers, Vol 13, Iss 5, p 1124 (2021)
Background: Since metastatic spreading of solid tumor cells often leads to a fatal outcome for most cancer patients, new approaches for patient-individualized, targeted immunotherapy are urgently needed. Methods: Here, we established cell lines from
Externí odkaz:
https://doaj.org/article/8bb501e9aae14af7a9c41a629c78a97f
Autor:
Emmanuel Donnadieu, Andrew D. Kaiser, Alain Trautmann, Nadège Bercovici, Elisabetta Dondi, Marco Alifano, Mathilde Sibony, Audrey Lupo, Diane Damotte, Ali Kinkhabwala, Nadine Mockel-Tenbrinck, Joerg Mittelstaet, Sandy Joaquina, Claire Gervais, Sandrine Haghiri, Lene Vimeux, Sarah Barrin, Chahrazade Kantari-Mimoun
Antibodies used in MACSima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599dc6637c55402b21849f3fa5913a32
https://doi.org/10.1158/2326-6066.22544645
https://doi.org/10.1158/2326-6066.22544645
Autor:
Emmanuel Donnadieu, Andrew D. Kaiser, Alain Trautmann, Nadège Bercovici, Elisabetta Dondi, Marco Alifano, Mathilde Sibony, Audrey Lupo, Diane Damotte, Ali Kinkhabwala, Nadine Mockel-Tenbrinck, Joerg Mittelstaet, Sandy Joaquina, Claire Gervais, Sandrine Haghiri, Lene Vimeux, Sarah Barrin, Chahrazade Kantari-Mimoun
Adoptive transfer of T cells expressing chimeric antigen receptors (CAR) has shown remarkable clinical efficacy against advanced B-cell malignancies but not yet against solid tumors. Here, we used fluorescent imaging microscopy and ex vivo assays to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089a36b4c500c26ff6de06bd9872533f
https://doi.org/10.1158/2326-6066.c.6550712
https://doi.org/10.1158/2326-6066.c.6550712
Autor:
Emmanuel Donnadieu, Andrew D. Kaiser, Alain Trautmann, Nadège Bercovici, Elisabetta Dondi, Marco Alifano, Mathilde Sibony, Audrey Lupo, Diane Damotte, Ali Kinkhabwala, Nadine Mockel-Tenbrinck, Joerg Mittelstaet, Sandy Joaquina, Claire Gervais, Sandrine Haghiri, Lene Vimeux, Sarah Barrin, Chahrazade Kantari-Mimoun
Legends for supplementary Figures and Videos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74587c1912aca06ee9f627a4ac98134d
https://doi.org/10.1158/2326-6066.22544675
https://doi.org/10.1158/2326-6066.22544675
Figure S3 from CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1
Autor:
Emmanuel Donnadieu, Andrew D. Kaiser, Alain Trautmann, Nadège Bercovici, Elisabetta Dondi, Marco Alifano, Mathilde Sibony, Audrey Lupo, Diane Damotte, Ali Kinkhabwala, Nadine Mockel-Tenbrinck, Joerg Mittelstaet, Sandy Joaquina, Claire Gervais, Sandrine Haghiri, Lene Vimeux, Sarah Barrin, Chahrazade Kantari-Mimoun
CAR T cell-induced ICAM-1 expression by tumor cells facilitates lymphocyte activation and entry into tumor islets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5588f7a93bef61b94f372cd2c4d91a
https://doi.org/10.1158/2326-6066.22544681.v1
https://doi.org/10.1158/2326-6066.22544681.v1