Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Joerg M, Buescher"'
Autor:
Matteo Villa, David E. Sanin, Petya Apostolova, Mauro Corrado, Agnieszka M. Kabat, Carmine Cristinzio, Annamaria Regina, Gustavo E. Carrizo, Nisha Rana, Michal A. Stanczak, Francesc Baixauli, Katarzyna M. Grzes, Jovana Cupovic, Francesca Solagna, Alexandra Hackl, Anna-Maria Globig, Fabian Hässler, Daniel J. Puleston, Beth Kelly, Nina Cabezas-Wallscheid, Peter Hasselblatt, Bertram Bengsch, Robert Zeiser, Sagar, Joerg M. Buescher, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment and how this process shapes the establishment of the CD8+ T cell pool.
Externí odkaz:
https://doaj.org/article/94dc27161c6a48b2b42944d1f1be38af
Autor:
Angela Castoldi, David E. Sanin, Nikki van Teijlingen Bakker, Cristhiane F. Aguiar, Lauar de Brito Monteiro, Nisha Rana, Katarzyna M. Grzes, Agnieszka M. Kabat, Jonathan Curtis, Alanna M. Cameron, George Caputa, Tiago Antônio de Souza, Fabrício O. Souto, Joerg M. Buescher, Joy Edwards-Hicks, Erika L. Pearce, Edward J. Pearce, Niels Olsen Saraiva Camara
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107719- (2023)
Summary: Little is known about the effects of high-fat diet (HFD)-induced obesity on resident colonic lamina propria (LP) macrophages (LPMs) function and metabolism. Here, we report that obesity and diabetes resulted in increased macrophage infiltrat
Externí odkaz:
https://doaj.org/article/70708d6c2e6b42e9aa409bf406d9bad6
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101408- (2022)
Summary: Metabolism is important for the regulation of hematopoietic stem cells (HSCs) and drives cellular fate. Due to the scarcity of HSCs, it has been technically challenging to perform metabolome analyses gaining insight into HSC metabolic regula
Externí odkaz:
https://doaj.org/article/169b196d841a48ba970b95799f328d22
Autor:
Katharina Schönberger, Michael Mitterer, Katharina Glaser, Manuel Stecher, Sebastian Hobitz, Dominik Schain-Zota, Konrad Schuldes, Tim Lämmermann, Angelika S. Rambold, Nina Cabezas-Wallscheid, Joerg M. Buescher
Publikováno v:
Analytical Chemistry
Metabolism plays a fundamental role in regulating cellular functions and fate decisions. Liquid chromatography-mass spectrometry (LC-MS)-based targeted metabolomic approaches provide high-resolution insights into the metabolic state of a cell. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6336947be60affc4b441a3a94a694847
https://doi.org/10.1021/acs.analchem.2c04396
https://doi.org/10.1021/acs.analchem.2c04396
Autor:
Indre Piragyte, Thomas Clapes, Aikaterini Polyzou, Ramon I. Klein Geltink, Stylianos Lefkopoulos, Na Yin, Pierre Cauchy, Jonathan D. Curtis, Lhéanna Klaeylé, Xavier Langa, Cora C. A. Beckmann, Marcin W. Wlodarski, Patrick Müller, Dominic Van Essen, Angelika Rambold, Friedrich G. Kapp, Marina Mione, Joerg M. Buescher, Erika L. Pearce, Alexander Polyzos, Eirini Trompouki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
HLX transcription factor regulates haematopoietic stem and progenitor cell (HSPC) differentiation and is overexpressed in acute myeloid leukemia. Here the authors show that HLX overexpression leads to myeloid differentiation block in zebrafish and hu
Externí odkaz:
https://doaj.org/article/6e1870de09fa401dacacea3d50a2697e
Autor:
Thiemo Zambanini, Hamed Hosseinpour Tehrani, Elena Geiser, Christiane K. Sonntag, Joerg M. Buescher, Guido Meurer, Nick Wierckx, Lars M. Blank
Publikováno v:
Metabolic Engineering Communications, Vol 4, Iss C, Pp 12-21 (2017)
Ustilago trichophora RK089 has been found recently as a good natural malic acid producer from glycerol. This strain has previously undergone adaptive laboratory evolution for enhanced substrate uptake rate resulting in the strain U. trichophora TZ1.
Externí odkaz:
https://doaj.org/article/5cc052bd87b8474b9ba785711f3695e0
Autor:
Thiemo Zambanini, Hamed Hosseinpour Tehrani, Elena Geiser, Dorothee Merker, Sarah Schleese, Judith Krabbe, Joerg M. Buescher, Guido Meurer, Nick Wierckx, Lars M. Blank
Publikováno v:
Biotechnology for Biofuels, Vol 10, Iss 1, Pp 1-15 (2017)
Abstract Background The family of Ustilaginaceae is known for their capability to naturally produce industrially valuable chemicals from different carbon sources. Recently, several Ustilaginaceae were reported to produce organic acids from glycerol,
Externí odkaz:
https://doaj.org/article/129e7a4c57d046f38fd8dcc56b53cdf8
Publikováno v:
Analytical Chemistry
Preprocessing of liquid chromatography-mass spectrometry (LC-MS) raw data facilitates downstream statistical and biological data analyses. In the case of targeted LC-MS data, consistent recognition of chromatographic peaks is a main challenge, in par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db459c50d7295d69753b676b770730b
https://doi.org/10.1021/acs.analchem.1c05224
https://doi.org/10.1021/acs.analchem.1c05224
Autor:
Omar Mossad, Bérénice Batut, Bahtiyar Yilmaz, Nikolaos Dokalis, Charlotte Mezö, Elisa Nent, Lara Susann Nabavi, Melanie Mayer, Feres José Mocayar Maron, Joerg M. Buescher, Mercedes Gomez de Agüero, Antal Szalay, Tim Lämmermann, Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg, Rolf Backofen, Daniel Erny, Marco Prinz, Thomas Blank
Publikováno v:
Nature Neuroscience
Microglial function declines during aging. The interaction of microglia with the gut microbiota has been well characterized during development and adulthood but not in aging. Here, we compared microglial transcriptomes from young-adult and aged mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1551beebbdeb2d3f40d654575609fd
https://doi.org/10.1038/s41593-022-01027-3
https://doi.org/10.1038/s41593-022-01027-3
Autor:
Joy Edwards-Hicks, Petya Apostolova, Joerg M. Buescher, Hannes Maib, Michal A. Stanczak, Mauro Corrado, Ramon I. Klein Geltink, Maria Elena Maccari, Matteo Villa, Gustavo E. Carrizo, David E. Sanin, Francesc Baixauli, Beth Kelly, Jonathan D. Curtis, Fabian Haessler, Annette Patterson, Cameron S. Field, George Caputa, Ryan L. Kyle, Melanie Soballa, Minsun Cha, Harry Paul, Jacob Martin, Katarzyna M. Grzes, Lea Flachsmann, Michael Mitterer, Liang Zhao, Frances Winkler, David Ali Rafei-Shamsabadi, Frank Meiss, Bertram Bengsch, Robert Zeiser, Daniel J. Puleston, David O’Sullivan, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Immunology
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well understood. Here we show that, although naive T cells are rich in polyunsaturated phosphoinositides (PIPn with 3-4 double bonds), Teff cells have unique PIPn marked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bcbbf423f9a7b51630fb44cecc15a8
https://hdl.handle.net/21.11116/0000-000D-12D6-D21.11116/0000-000D-12D8-B
https://hdl.handle.net/21.11116/0000-000D-12D6-D21.11116/0000-000D-12D8-B
