Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joerg Kley"'
Autor:
Patrick Baum, Trixi Brandl, Detlev Mennerich, Stefan Hoerer, Gisela Schnapp, Joerg Kley, Gerald Juergen Roth, Matthias Grauert, Andreas Schnapp, Armin Heckel, John Edward Park
Publikováno v:
Journal of Medicinal Chemistry. 53:7287-7295
Inhibition of transforming growth factor β (TGFβ) type I receptor (Alk5) offers a novel approach for the treatment of fibrotic diseases and cancer. Indolinones substituted in position 6 were identified as a new chemotype inhibiting TGFβRI concomit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d25f7b7185111b6fc49da6b8d1fb20
https://doi.org/10.1021/jm100812a
https://doi.org/10.1021/jm100812a
Publikováno v:
Synthesis. :3279-3282
Furan-2-ylmethyl, thien-2-ylmethyl and pyrrol-2-ylmethyl tosylacetates undergo facile decarboxylative Claisen rearrangement upon exposure to N,O-bis(trimethylsilyl)acetamide-potassium acetate to yield the corresponding 2,3-disubstituted heteroaromati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8b0766672d84058ea5d26aa795bb13
https://doi.org/10.1055/s-2005-918448
https://doi.org/10.1055/s-2005-918448
Autor:
Joerg Kley, Uwe Ries, Herbert Nar, Paul Declerck, Ann Gils, Wolfgang Wienen, Jean-Marie Stassen
Publikováno v:
Thrombosis and Haemostasis. 88:137-143
SummaryPlasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor of both tissue-type plasminogen activator and urokinasetype plasminogen activator in plasma, is a well established risk factor in thrombotic diseases. Reduction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c081128d7d01923c6a62f77822dcd4
https://doi.org/10.1055/s-0037-1613166
https://doi.org/10.1055/s-0037-1613166
Publikováno v:
ChemInform. 43
Based on a high-throughput screening, cyclopentanecarboxanilides (I) are identified as a new chemotype of non-covalent inhibitors of type 1 fatty acid synthase (FAS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab9bab4068aefe0d5f2380263dc8e8be
https://doi.org/10.1002/chin.201208219
https://doi.org/10.1002/chin.201208219
Publikováno v:
Bioorganic & Medicinal Chemistry Letters.
Based on a high-throughput screen, cyclopentanecarboxanilides were identified as a new chemotype of non-covalent inhibitors of type I fatty acid synthase (FAS). Starting from initial hits we aimed at generating a tool compound suitable for the in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8a43e15ab3ee3dde46ee6871fa7ff4
https://doi.org/10.1016/j.bmcl.2011.07.083
https://doi.org/10.1016/j.bmcl.2011.07.083
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3c1816917559e5d317b3dc7906e0b42
https://doi.org/10.1002/chin.199819239
https://doi.org/10.1002/chin.199819239
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13b56a01c84d1cacf9dc2976206edc79
https://doi.org/10.1002/chin.199920211
https://doi.org/10.1002/chin.199920211