Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joerg Kahle"'
Autor:
Courtney Cox, Christoph Königs, Joerg Kahle, John F. Healey, Ernest T. Parker, Brenda Nguyen, W. Hunter Baldwin, Glaivy Batsuli, Renhao Li, Wei Deng, Shannon L. Meeks, Pete Lollar
Publikováno v:
Blood. 128:2055-2067
Inhibitor formation in hemophilia A is the most feared treatment-related complication of factor VIII (fVIII) therapy. Most inhibitor patients with hemophilia A develop antibodies against the fVIII A2 and C2 domains. Recent evidence demonstrates that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72f98b573adc771aa89551e0386d346f
https://doi.org/10.1182/blood-2016-02-701805
https://doi.org/10.1182/blood-2016-02-701805
Autor:
Ali Kabiri, Diana Stichel, Joerg Kahle, Pete Lollar, John F. Healey, Karin Becker-Peters, Anja Naumann, Anna Katharina Scherger, Aleksander Orlowski, Christoph Königs, Dirk Schwabe, Kerstin Brettschneider
Publikováno v:
Thrombosis and Haemostasis. 113:396-405
SummaryThe most serious complication in today’s treatment of congenital haemophilia A is the development of neutralising antibodies (inhibitors) against factor VIII (FVIII). Although FVIII inhibitors can be eliminated by immune tolerance induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bdb59abaf14a6fcfb2cc2aa1ff2d3a
https://doi.org/10.1160/th14-01-0101
https://doi.org/10.1160/th14-01-0101
Autor:
Pete Lollar, Aleksander Orlowski, John F. Healey, Diana Stichel, Christoph Königs, Ernest T. Parker, Manuela Krause, Dirk Schwabe, Marc Jacquemin, Joerg Kahle, Andreas Tiede
Publikováno v:
Blood. 130(6)
Several studies showed that neutralizing anti-factor VIII (anti-fVIII) antibodies (inhibitors) in patients with acquired hemophilia A (AHA) and congenital hemophilia A (HA) are primarily directed to the A2 and C2 domains. In this study, the frequency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9b8f1bdf5a49c3233d835033b68328
https://pubmed.ncbi.nlm.nih.gov/28507083
https://pubmed.ncbi.nlm.nih.gov/28507083
Publikováno v:
Journal of Biological Chemistry. 282:35821-35830
DNA cleavage is a biochemical hallmark of apoptosis. In humans, apoptotic DNA cleavage is executed by DNA fragmentation factor (DFF) 40. In proliferating cells DFF40 is expressed in the presence of its chaperone and inhibitor DFF45, which results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70434eda6a87b873e830b5aa5249653f
https://doi.org/10.1074/jbc.m703110200
https://doi.org/10.1074/jbc.m703110200
Publikováno v:
Molecular and Cellular Biology. 25:5339-5354
The transcriptional activator NF-Y is a heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC, which specifically binds the CCAAT consensus present in about 30% of eukaryotic promoters. All three subunits contain evolutionarily conserved core re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70912092131789f581588af0b62d986c
https://doi.org/10.1128/mcb.25.13.5339-5354.2005
https://doi.org/10.1128/mcb.25.13.5339-5354.2005
Publikováno v:
Biochemical Journal. 384:317-326
We have analysed the transcriptional regulation of the human histone H3 genes using promoter deletion series, scanning mutagenesis, specific mutagenesis and electrophoretic mobility-shift assay experiments. The promoters of five of the six examined h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537883dd56a7a7f109249e92ae5df133
https://doi.org/10.1042/bj20040502
https://doi.org/10.1042/bj20040502
Autor:
Christine Heller, Diana Stichel, Dirk Schwabe, Sonja Neimanis, Joerg Kahle, Thomas Klingebiel, Anja Schmidt, Karin Becker-Peters, Aleksander Orlowski, Kerstin Brettschneider, Christoph Koenigs
Publikováno v:
Blood. 128:561-561
The development of inhibitory antibodies (inhibitors) against coagulation factor VIII (FVIII) is the most serious complication for patients with hemophilia A that undergo FVIII replacement therapy. In addition, healthy individuals can spontaneously d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50a493b546f53c10fe26b4901c4f623a
https://doi.org/10.1182/blood.v128.22.561.561
https://doi.org/10.1182/blood.v128.22.561.561
Autor:
Andreas Tiede, Anja Schmidt, Marc Jacquemin, John S. Lollar, Joerg Kahle, Manuela Krause, John F. Healey, Thomas Klingebiel, Kerstin Brettschneider, Ernest T. Parker, Dirk Schwabe, Aleksander Orlowski, Christoph Königs
Publikováno v:
Blood. 126:3491-3491
Acquired hemophilia A (AHA) is a rare autoimmune disease caused by development of inhibitory anti-factor VIII (fVIII) antibodies (also called inhibitors) resulting in severe hemorrhages. In addition, inhibitor development is the most serious complica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0095cbd0a932fa50832a549ef3f2ccc0
https://doi.org/10.1182/blood.v126.23.3491.3491
https://doi.org/10.1182/blood.v126.23.3491.3491
Autor:
Lisa Egerer, Dorothee von Laer, Frances Brauer, Andreas Volk, Joerg Kahle, Janine Kimpel, Felix G. Hermann
Gene therapeutic strategies for human immunodeficiency virus type 1 (HIV-1) infection could potentially overcome the limitations of standard antiretroviral drug therapy (ART). However, in none of the clinical gene therapy trials published to date, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c0984e0b2453f68ab5b424165f3285
https://europepmc.org/articles/PMC3129562/
https://europepmc.org/articles/PMC3129562/
The histone fold is a structural element that facilitates heterodimerization, and histone fold heterodimers play crucial roles in gene regulation. Here, we investigated the nuclear import of two human histone fold pairs, which belong to the H2A/H2B f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1af9c345f90948beb606be63787674d
https://europepmc.org/articles/PMC2670169/
https://europepmc.org/articles/PMC2670169/