Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Joerg Galle"'
Publikováno v:
Bioengineering, Vol 10, Iss 1, p 50 (2022)
The implementation of stem-cell-based organoid culture more than ten years ago started a development that created new avenues for diagnostic analyses and regenerative medicine. In parallel, computational modelling groups realized the potential of thi
Externí odkaz:
https://doaj.org/article/d67d2df470ad4488b37f91cfaaed4f96
Autor:
Maria Herberg, Susann Siebert, Marianne Quaas, Torsten Thalheim, Karen Rother, Michelle Hussong, Janine Altmüller, Christiane Kerner, Joerg Galle, Michal R. Schweiger, Gabriela Aust
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide hist
Externí odkaz:
https://doaj.org/article/f3652322832b4382953c498b1a202463
Autor:
Torsten Thalheim, Susann Siebert, Marianne Quaas, Maria Herberg, Michal R. Schweiger, Gabriela Aust, Joerg Galle
Publikováno v:
Cells, Vol 10, Iss 7, p 1718 (2021)
Organoids retain the morphological and molecular patterns of their tissue of origin, are self-organizing, relatively simple to handle and accessible to genetic engineering. Thus, they represent an optimal tool for studying the mechanisms of tissue ma
Externí odkaz:
https://doaj.org/article/6fb7b01a7af7439ab750ca6aef8fc842
Autor:
Felix Hofmann, Torsten Thalheim, Karen Rother, Marianne Quaas, Christiane Kerner, Jens Przybilla, Gabriela Aust, Joerg Galle
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7345 (2021)
Intestinal cylindrical growth peaks in mice a few weeks after birth, simultaneously with crypt fission activity. It nearly stops after weaning and cannot be reactivated later. Transgenic mice expressing Cd97/Adgre5 in the intestinal epithelium develo
Externí odkaz:
https://doaj.org/article/0d80381d6eb843a28d1e798fa3000614
Publikováno v:
Epigenetics, Vol 12, Iss 10, Pp 886-896 (2017)
In acute myeloid leukemia (AML) DNA hypermethylation of gene promoters is frequently observed and often correlates with a block of differentiation. Treatment of AML patients with DNA methyltransferase inhibitors results in global hypomethylation of g
Externí odkaz:
https://doaj.org/article/0c46c74deb3840268875593564b28cbf
Autor:
Torsten Thalheim, Lydia Hopp, Maria Herberg, Susann Siebert, Christiane Kerner, Marianne Quaas, Michal R. Schweiger, Gabriela Aust, Joerg Galle
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1941 (2020)
Aberrant DNA methylation in stem cells is a hallmark of aging and tumor development. Recently, we have suggested that promoter DNA hyper-methylation originates in DNA repair and that even successful DNA repair might confer this kind of epigenetic lon
Externí odkaz:
https://doaj.org/article/a9cffac013004e5f99dfc74d64057328
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 349-356 (2013)
The pyloric epithelium continuously self-renews throughout life, driven by limited reservoirs of resident Lgr5+ adult stem cells. Here, we characterize the population dynamics of these stem cells during epithelial homeostasis. Using a clonal fate-map
Externí odkaz:
https://doaj.org/article/c22dbe7c18854d9faebb08948b83ce68
Publikováno v:
Epigenomes, Vol 2, Iss 4, p 20 (2018)
It is generally accepted that epigenetic modifications, such as DNA and histone methylations, affect transcription and that a gene’s transcription feeds back on its epigenetic profile. Depending on the epigenetic modification, positive and negative
Externí odkaz:
https://doaj.org/article/e90397b4867241ec81f42b9e33b43034
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21960 (2011)
Therapeutic application of mesenchymal stem cells (MSC) requires their extensive in vitro expansion. MSC in culture typically grow to confluence within a few weeks. They show spindle-shaped fibroblastoid morphology and align to each other in characte
Externí odkaz:
https://doaj.org/article/01369d99002d454f826e6a735164c43c
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2922 (2008)
The balance between maintenance of the stem cell state and terminal differentiation is influenced by the cellular environment. The switching between these states has long been understood as a transition between attractor states of a molecular network
Externí odkaz:
https://doaj.org/article/9a647bbfacb74820be22a99af7ec2a59