Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Joerg, Kallen"'
Autor:
Jacob Stewart-Ornstein, Yoshiko Iwamoto, Miles A. Miller, Mark A. Prytyskach, Stephane Ferretti, Philipp Holzer, Joerg Kallen, Pascal Furet, Ashwini Jambhekar, William C. Forrester, Ralph Weissleder, Galit Lahav
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor
Externí odkaz:
https://doaj.org/article/ec4f9099e0ec49f6920b6fbb19143619
Autor:
Yannick Mesrouze, Hanspeter Gubler, Frédéric Villard, Ralf Boesch, Johannes Ottl, Joerg Kallen, Patrick C. Reid, Clemens Scheufler, Andreas L. Marzinzik, Patrick Chène
Publikováno v:
ACS Chemical Biology. 18:643-651
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4808188d8d2d91d270aa5073b3cd649
https://doi.org/10.1021/acschembio.2c00936
https://doi.org/10.1021/acschembio.2c00936
Autor:
Holger Sellner, Emilie Chapeau, Pascal Furet, Markus Voegtle, Bahaa Salem, Mickaël Le Douget, Vincent Bordas, Jean‐Marc Groell, Anne‐Laure Le Goff, Christine Rouzet, Thomas Wietlisbach, Thomas Zimmermann, Joseph McKenna, Cara E. Brocklehurst, Patrick Chène, Markus Wartmann, Clemens Scheufler, Joerg Kallen, Gareth Williams, Stephanie Harlfinger, Martin Traebert, Bérengère M. Dumotier, Tobias Schmelzle, Nicolas Soldermann
Publikováno v:
ChemMedChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87689f9fe496e8ff4e8b8008d72b261f
https://doi.org/10.1002/cmdc.202300051
https://doi.org/10.1002/cmdc.202300051
Autor:
William R. Sellers, Francesco Hofmann, Michael R. Jensen, Marion Wiesmann, Emil Kuriakose, Audrey Kauffmann, Astrid Jullion, Ensar Halilovic, Nelson Guerreiro, Jens Würthner, Pascal Furet, Joerg Kallen, Therese-Marie Stachyra, Stephan Ruetz, Marta Cortes-Cros, Swann Gaulis, Eric Y. Durand, Grainne Kerr, Masato Murakami, Vincent Romanet, Dario Sterker, Markus Wartmann, Emilie A. Chapeau, Jeanette Fuchs, Philipp Holzer, Stéphane Ferretti, Sébastien Jeay
Median of the shRNAs and RSA values. File containing median counts and log fold changes of each gene from Supplementary Data File S1. According significance values of each gene as activator or sensitizer compared to DMSO control (see Methods) are inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fb2879a6749b92d41888b92af04a38
https://doi.org/10.1158/0008-5472.22420067.v1
https://doi.org/10.1158/0008-5472.22420067.v1
Autor:
William R. Sellers, Francesco Hofmann, Michael R. Jensen, Marion Wiesmann, Emil Kuriakose, Audrey Kauffmann, Astrid Jullion, Ensar Halilovic, Nelson Guerreiro, Jens Würthner, Pascal Furet, Joerg Kallen, Therese-Marie Stachyra, Stephan Ruetz, Marta Cortes-Cros, Swann Gaulis, Eric Y. Durand, Grainne Kerr, Masato Murakami, Vincent Romanet, Dario Sterker, Markus Wartmann, Emilie A. Chapeau, Jeanette Fuchs, Philipp Holzer, Stéphane Ferretti, Sébastien Jeay
Activation of p53 by inhibitors of the p53–MDM2 interaction is being pursued as a therapeutic strategy in p53 wild-type cancers. Here, we report distinct mechanisms by which the novel, potent, and selective inhibitor of the p53–MDM2 interaction H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::defcbf6d8ab85cdf500b16956270b3ec
https://doi.org/10.1158/0008-5472.c.6510551.v1
https://doi.org/10.1158/0008-5472.c.6510551.v1
Autor:
William R. Sellers, Francesco Hofmann, Michael R. Jensen, Marion Wiesmann, Emil Kuriakose, Audrey Kauffmann, Astrid Jullion, Ensar Halilovic, Nelson Guerreiro, Jens Würthner, Pascal Furet, Joerg Kallen, Therese-Marie Stachyra, Stephan Ruetz, Marta Cortes-Cros, Swann Gaulis, Eric Y. Durand, Grainne Kerr, Masato Murakami, Vincent Romanet, Dario Sterker, Markus Wartmann, Emilie A. Chapeau, Jeanette Fuchs, Philipp Holzer, Stéphane Ferretti, Sébastien Jeay
Supplementary material and methods include the description for the bioanalytical method for HDM201 detection in plasma and tumor, the human and mouse gene expression analysis in vitro and in vivo, the live-cell quantification of cleaved-caspase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b82fed93efadb9ad16a5268c6dd4a1d
https://doi.org/10.1158/0008-5472.22420061
https://doi.org/10.1158/0008-5472.22420061
Akademický článek
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Autor:
Fedir Bokhovchuk, Yannick Mesrouze, Marco Meyerhofer, Patrizia Fontana, Catherine Zimmermann, Frédéric Villard, Dirk Erdmann, Joerg Kallen, Clemens Scheufler, Camilo Velez‐Vega, Patrick Chène
Publikováno v:
Protein science : a publication of the Protein Society. 32(1)
The yes-associated protein (YAP) regulates the transcriptional activity of the TEAD transcription factors that are key in the control of organ morphogenesis. YAP interacts with TEAD via three secondary structure elements: a β-strand, an α-helix, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affa184f655fa01734677caf77960a1a
https://pubmed.ncbi.nlm.nih.gov/36522189
https://pubmed.ncbi.nlm.nih.gov/36522189
Autor:
Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaa Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie Chapeau, Markus Wartmann, Clemens Scheufler, Cesar Fernandez, Joerg Kallen, Vito Guagnano, Patrick Chène, Tobias Schmelzle
Publikováno v:
ChemMedChem. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72eaa7a7b52b189acf9bc634916ec5d3
https://doi.org/10.1002/cmdc.202200514
https://doi.org/10.1002/cmdc.202200514
Autor:
Samuel Hintermann, Andreas Marzinzik, Johannes Ottl, Joerg Kallen, Therese-Marie Stachyra, Patrick C. Reid, Stephan Ruetz, Anselm F. L. Schneider, Christian P. R. Hackenberger, Christoph E. Dumelin, Sebastien Ripoche
Publikováno v:
RSC Chemical Biology
Mouse double minute 2 homolog (MDM2, Hdm2) is an important negative regulator of the tumor suppressor p53. Using a mRNA based display technique to screen a library of >1012in vitro-translated cyclic peptides, we have identified a macrocyclic ligand t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79c0089311703a726113d94f5b84104
http://europepmc.org/articles/PMC8637822
http://europepmc.org/articles/PMC8637822