Zobrazeno 1 - 10
of 334
pro vyhledávání: '"Joerg, Heeren"'
Autor:
Benjamin Bay, Marceline M. Fuh, Julia Rohde, Anna Worthmann, Alina Goßling, Natalie Arnold, Lukas Koester, Thiess Lorenz, Christopher Blaum, Paulus Kirchhof, Stefan Blankenberg, Moritz Seiffert, Fabian J. Brunner, Christoph Waldeyer, Joerg Heeren
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background Lipids, including phospholipids and bile acids, exert various signaling effects and are thought to contribute to the development of coronary artery disease (CAD). Here, we aimed to compare lipidomic and bile acid profiles in the b
Externí odkaz:
https://doaj.org/article/a6229e4e270d4438b96d86ae2a432d50
Autor:
Janina Behrens, Ingke Braren, Michelle Y. Jaeckstein, Luka Lilie, Markus Heine, Finnja Sass, Judith Sommer, Dagmar Silbert-Wagner, Marceline M. Fuh, Anna Worthmann, Leon Straub, Tarek Moustafa, Joerg Heeren, Ludger Scheja
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 101999- (2024)
Objective: Recombinant adeno-associated virus (rAAV) vectors are powerful tools for the sustained expression of proteins in vivo and have been successfully used for mechanistic studies in mice. A major challenge associated with this method is to obta
Externí odkaz:
https://doaj.org/article/107161de55d9488bb70aeb07ce4f4045
Autor:
Friederike Behler-Janbeck, Anke Baranowsky, Timur A. Yorgan, Michelle Y. Jaeckstein, Anna Worthmann, Marceline M. Fuh, Karthikeyan Gunasekaran, Gisa Tiegs, Michael Amling, Thorsten Schinke, Joerg Heeren
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Bone is a dynamic tissue that is constantly remodeled throughout adult life. Recently, it has been shown that bone turnover decreases shortly after food consumption. This process has been linked to the fermentation of non-digestible food ingredients
Externí odkaz:
https://doaj.org/article/8ae75f068f8046b7bb571f37fd7660ae
Autor:
Anna Worthmann, Julius Ridder, Sharlaine Y. L. Piel, Ioannis Evangelakos, Melina Musfeldt, Hannah Voß, Marie O’Farrell, Alexander W. Fischer, Sangeeta Adak, Monica Sundd, Hasibullah Siffeti, Friederike Haumann, Katja Kloth, Tatjana Bierhals, Markus Heine, Paul Pertzborn, Mira Pauly, Julia-Josefine Scholz, Suman Kundu, Marceline M. Fuh, Axel Neu, Klaus Tödter, Maja Hempel, Uwe Knippschild, Clay F. Semenkovich, Hartmut Schlüter, Joerg Heeren, Ludger Scheja, Christian Kubisch, Christian Schlein
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous fatty acids – a process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases. D
Externí odkaz:
https://doaj.org/article/d4a6b8efd8424ceaa3b39a71f53879ef
Autor:
Valerie J. Brock, Niels Christian Lory, Franziska Möckl, Melina Birus, Tobias Stähler, Lena-Marie Woelk, Michelle Jaeckstein, Joerg Heeren, Friedrich Koch-Nolte, Björn Rissiek, Hans-Willi Mittrücker, Andreas H. Guse, René Werner, Björn-Philipp Diercks
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CD8+ T cells are a crucial part of the adaptive immune system, responsible for combating intracellular pathogens and tumor cells. The initial activation of T cells involves the formation of highly dynamic Ca2+ microdomains. Recently, purinergic signa
Externí odkaz:
https://doaj.org/article/a2847c04e466468e97ea1424969ec6f1
Autor:
Andrea Benzi, Markus Heine, Sonia Spinelli, Annalisa Salis, Anna Worthmann, Björn Diercks, Cecilia Astigiano, Raúl Pérez Mato, Adela Memushaj, Laura Sturla, Valerio Vellone, Gianluca Damonte, Michelle Y. Jaeckstein, Friedrich Koch-Nolte, Hans-Willi Mittrücker, Andreas H. Guse, Antonio De Flora, Joerg Heeren, Santina Bruzzone
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
IntroductionDuring thermogenesis, adipose tissue (AT) becomes more active and enhances oxidative metabolism. The promotion of this process in white AT (WAT) is called “browning” and, together with the brown AT (BAT) activation, is considered as a
Externí odkaz:
https://doaj.org/article/6cbc007a0f474be38c4530fd56e6e433
Autor:
Michelle Y. Jaeckstein, Isabell Schulze, Michael Wolfgang Zajac, Markus Heine, Oliver Mann, Alexander Pfeifer, Joerg Heeren
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Next to white and brown adipocytes present in white and brown adipose tissue (WAT, BAT), vascular endothelial cells, tissue-resident macrophages and other immune cells have important roles in maintaining adipose tissue homeostasis but also contribute
Externí odkaz:
https://doaj.org/article/a3c18f1e0f9f4b0997e75595158ef373
Publikováno v:
Adipocyte, Vol 11, Iss 1, Pp 28-33 (2022)
Oxidative tissues such as brown adipose tissue and muscle internalize large amounts of circulating lipids and glucose as energy source. Endothelial cells (ECs) provide a platform for regulated transport and processing of blood-borne nutrients. Next t
Externí odkaz:
https://doaj.org/article/c3b1b677bfdf4ba08bf0289a599bd288
Autor:
Julian Stürznickel, Friederike Behler-Janbeck, Anke Baranowsky, Tobias Schmidt, Dorothee Schwinge, Clara John, Ansgar W. Lohse, Christoph Schramm, Joerg Heeren, Thorsten Schinke, Michael Amling
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Primary sclerosing cholangitis (PSC) is an idiopathic cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of intra- and extrahepatic bile ducts. Osteoporosis is a frequent comorbidity in PSC, and we could
Externí odkaz:
https://doaj.org/article/d7c763f5573d4cf5bf7c82ef35f5acfe
Autor:
Steven Schepanski, Mattia Chini, Veronika Sternemann, Christopher Urbschat, Kristin Thiele, Ting Sun, Yu Zhao, Mareike Poburski, Anna Woestemeier, Marie-Theres Thieme, Dimitra E. Zazara, Malik Alawi, Nicole Fischer, Joerg Heeren, Nikita Vladimirov, Andrew Woehler, Victor G. Puelles, Stefan Bonn, Nicola Gagliani, Ileana L. Hanganu-Opatz, Petra C. Arck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
During pregnancy, maternal cells are transferred to the fetus, where they can reach the developing brain. In this study, the authors demonstrate that these maternal cells play an important role in neurodevelopment.
Externí odkaz:
https://doaj.org/article/f28f78dbe76547abbc4cadf7463e2b41