Combinatorial optimization of pathway, process and media for the production of p‐coumaric acid by Saccharomyces cerevisiae

Autor: Sara Moreno‐Paz, Rianne van derHoek, Elif Eliana, Vitor A. P. Martins dos Santos, Joep Schmitz, Maria Suarez‐Diez

Publikováno v: Microbial Biotechnology, Vol 17, Iss 3, Pp n/a-n/a (2024)

Abstract Microbial cell factories are instrumental in transitioning towards a sustainable bio‐based economy, offering alternatives to conventional chemical processes. However, fulfilling their potential requires simultaneous screening for optimal m

Externí odkaz: https://doaj.org/article/2899d32f687444d289eabde6ece42528

Enzyme‐constrained models predict the dynamics of Saccharomyces cerevisiae growth in continuous, batch and fed‐batch bioreactors

Autor: Sara Moreno‐Paz, Joep Schmitz, Vitor A. P. Martins dos Santos, Maria Suarez‐Diez

Publikováno v: Microbial Biotechnology, Vol 15, Iss 5, Pp 1434-1445 (2022)

Summary Genome‐scale, constraint‐based models (GEM) and their derivatives are commonly used to model and gain insights into microbial metabolism. Often, however, their accuracy and predictive power are limited and enable only approximate designs.

Externí odkaz: https://doaj.org/article/42b79b63600c4ebcb5f48aef05c838d7

Kinetic Modeling of Saccharomyces cerevisiae Central Carbon Metabolism: Achievements, Limitations, and Opportunities

Autor: David Lao-Martil, Koen Verhagen, Joep Schmitz, Bas Teusink, S. Wahl, Natal van Riel

Publikováno v: Lao-Martil, D, Verhagen, K J A, Schmitz, J P J, Teusink, B, Wahl, S A & van Riel, N A W 2022, ' Kinetic Modeling of Saccharomyces cerevisiae Central Carbon Metabolism : Achievements, Limitations, and Opportunities ', Metabolites, vol. 12, no. 1, 74, pp. 1-23 . https://doi.org/10.3390/metabo12010074
Metabolites, Vol 12, Iss 74, p 74 (2022)

Central carbon metabolism comprises the metabolic pathways in the cell that process nutrients into energy, building blocks and byproducts. To unravel the regulation of this network upon glucose perturbation, several metabolic models have been develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543d2b583cc8aa1d5ff50a6caf13b731
https://doi.org/10.3390/metabo12010074

Computational modeling of mitochondrial energy transduction

Autor: Jal Jeroen Jeneson, van Naw Natal Riel, Jpj Joep Schmitz, J Joep Vanlier

Publikováno v: Critical Reviews in Biomedical Engineering, 39(5), 363-377. Begell House Inc.
Pure TUe
Scopus-Elsevier

Mitochondria are the power plant of the heart, burning fat and sugars to supply the muscle with the adenosine triphosphate (ATP) free energy that drives contraction and relaxation during each heart beat. This function was first captured in a mathemat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c016c11a23e21bf4798192fd90adbf0d
https://research.tue.nl/nl/publications/27ddbcbb-ce76-4309-851c-6382425373a5

Simulated Design-Build-Test-Learn Cycles for Consistent Comparison of Machine Learning Methods in Metabolic Engineering.

Autor: van Lent P; Delft Bioinformatics Lab, Delft University of Technology Van Mourik, Delft 2628 XE, The Netherlands., Schmitz J; Department of Science and Research, Joep Schmitz - dsm-firmenich, Science & Research, P.O. Box 1, 2600 MA Delft, The Netherlands., Abeel T; Delft Bioinformatics Lab, Delft University of Technology Van Mourik, Delft 2628 XE, The Netherlands.; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.

Publikováno v: ACS synthetic biology [ACS Synth Biol] 2023 Sep 15; Vol. 12 (9), pp. 2588-2599. Date of Electronic Publication: 2023 Aug 24.