Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joep Brinkmann"'
Publikováno v:
Cancers, Vol 2, Iss 2, Pp 376-396 (2010)
In addition to a wide range of adverse effects on human health, toxic metals such as cadmium, arsenic and nickel can also promote carcinogenesis. The toxicological properties of these metals are partly related to generation of reactive oxygen species
Externí odkaz:
https://doaj.org/article/474f1f140c70420581d93e690262cd60
Autor:
Andrei Tintu, Ellen Rouwet, Stefan Verlohren, Joep Brinkmann, Shakil Ahmad, Fatima Crispi, Marc van Bilsen, Peter Carmeliet, Anne Cathrine Staff, Marc Tjwa, Irene Cetin, Eduard Gratacos, Edgar Hernandez-Andrade, Leo Hofstra, Michael Jacobs, Wouter H Lamers, Ingo Morano, Erdal Safak, Asif Ahmed, Ferdinand le Noble
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5155 (2009)
BACKGROUND:Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction. We have previously shown that chronic hypoxia alte
Externí odkaz:
https://doaj.org/article/f94e4ab0c7db40d088273cfe1bd108d2
Autor:
V. Blatz, Frank Henkler, Kerstin Reisinger, Stefan Pfuhler, Astrid A. Reus, Anja Fischer, Cyrille Krul, Sebastian Hoffmann, Thomas R. Downs, Manfred Liebsch, Markus Schulz, Joep Brinkmann, Andreas Luch, Ralph Pirow
Publikováno v:
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 827, 27-41
Recently revised OECD Testing Guidelines highlight the importance of considering the first site-of-contact when investigating the genotoxic hazard. Thus far, only in vivo approaches are available to address the dermal route of exposure. The 3D Skin C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b28f110d466e7f79407b358511cdc1c
http://resolver.tudelft.nl/uuid:153766fa-4050-432f-bb78-384547d26059
http://resolver.tudelft.nl/uuid:153766fa-4050-432f-bb78-384547d26059
Publikováno v:
Polycyclic Aromatic Compounds. 35:32-40
Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BP), are detectable in certain consumer products, including newspapers. We investigated the release of PAHs from newspapers and the fate and effects of BP in human skin models. The migr
Autor:
Bryan Hellack, Joep Brinkmann, Martin Wiemann, Aileen Bahl, Andreas Luch, Mihaela Balas, Anca Dinischiotu, Bernhard Y. Renard, Andrea Haase
Publikováno v:
NanoImpact. 15:100179
Nanomaterials (NMs) can be produced in numerous different variants of the same chemical substance. An in-depth safety assessment for each variant by generating test data will simply not be feasible. Thus, NM grouping approaches that would significant
Autor:
Joep Brinkmann, Andreas Luch, Tewes Tralau, Christian Kern, Frank Henkler, Anna Tkachenko, Juliane Sowada, Doris Genkinger
Publikováno v:
Scientific Reports
The aryl hydrocarbon receptor (AHR) shuttles continuously between cytoplasm and nucleus, unless ligand-binding triggers association with the AHR nuclear translocator (ARNT) and subsequent binding to cognate DNA motifs. We have now identified Val 647
Autor:
Andreas Luch, Christoph Hutzler, Udo Bock, Susanne Trappe, Joep Brinkmann, Timo Otter, Kristin Stolpmann, Frank Henkler, Manfred Liebsch, Doris Genkinger
Publikováno v:
Toxicological Sciences
The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) is metabolized into a complex pattern of BP derivatives, among which the ultimate carcinogen (+)-anti-BP-7,8-diol-9,10-epoxide (BPDE) is formed to certain extents. Skin is frequently in co
Autor:
Katja Scholz, Salim Abdelilah-Seyfried, Janna Krueger, Christian Klein, Ferdinand le Noble, Justus Veerkamp, Joep Brinkmann, Janine Mikutta, Doreen Siegel, Dong Liu
Publikováno v:
Development (Cambridge, England). 138(10)
Endodermal organogenesis requires a precise orchestration of cell fate specification and cell movements, collectively coordinating organ size and shape. In Caenorhabditis elegans, uncoordinated-53 (unc-53) encodes a neural guidance molecule that dire
Autor:
Shakil Ahmad, Marc Tjwa, Asif Ahmed, Peter Carmeliet, Wouter H. Lamers, Ferdinand le Noble, Ingo Morano, Irene Cetin, Anne Cathrine Staff, Leonard Hofstra, Erdal Safak, Michael J. Jacobs, Joep Brinkmann, Ellen V. Rouwet, Andrei Tintu, Eduard Gratacós, Edgar Hernandez-Andrade, Fatima Crispi, Stefan Verlohren, Marc van Bilsen
Publikováno v:
PLOS ONE, 4(4):e5155. Public Library of Science
PLoS ONE
PLoS ONE, Vol 4, Iss 4, p e5155 (2009)
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, 4(4). Public Library of Science
Recercat. Dipósit de la Recerca de Catalunya
instname
Tintu, A, Rouwet, E, Verlohren, S, Brinkmann, J, Ahmad, S, Crispi, F, van Bilsen, M, Carmeliet, P, Staff, A C, Tjwa, M, Cetin, I, Gratacos, E, Hernandez-Andrade, E, Hofstra, L, Jacobs, M, Lamers, W H, Morano, I, Safak, E, Ahmed, A & le Noble, F 2009, ' Hypoxia induces dilated cardiomyopathy in the chick embryo : mechanism, intervention, and long-term consequences ', PLoS ONE, vol. 4, no. 4, pp. e5155 . https://doi.org/10.1371/journal.pone.0005155
PLoS ONE
PLoS ONE, Vol 4, Iss 4, p e5155 (2009)
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE, 4(4). Public Library of Science
Recercat. Dipósit de la Recerca de Catalunya
instname
Tintu, A, Rouwet, E, Verlohren, S, Brinkmann, J, Ahmad, S, Crispi, F, van Bilsen, M, Carmeliet, P, Staff, A C, Tjwa, M, Cetin, I, Gratacos, E, Hernandez-Andrade, E, Hofstra, L, Jacobs, M, Lamers, W H, Morano, I, Safak, E, Ahmed, A & le Noble, F 2009, ' Hypoxia induces dilated cardiomyopathy in the chick embryo : mechanism, intervention, and long-term consequences ', PLoS ONE, vol. 4, no. 4, pp. e5155 . https://doi.org/10.1371/journal.pone.0005155
Background - Intrauterine growth restriction is associated with an increased future risk for developing cardiovascular diseases. Hypoxia in utero is a common clinical cause of fetal growth restriction. We have previously shown that chronic hypoxia al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c16bdd410f5f79b829ae6b7d7b6a2a
https://cris.maastrichtuniversity.nl/en/publications/6e1117c4-e639-4c42-b5e4-8292a4d179a1
https://cris.maastrichtuniversity.nl/en/publications/6e1117c4-e639-4c42-b5e4-8292a4d179a1
Autor:
Joep Brinkmann, Harald Wajant, Steffen Salzmann, Frank Henkler, Andreas Luch, Christoph Hutzler, Kristin Stolpmann, Doris Genkinger, E Fritsche
Publikováno v:
Cell Death & Disease
In this study, we have analysed the apoptotic effects of the ubiquitous environmental toxin benzo[ a] pyrene (BP) in HaCaT cells and human keratinocytes. Although prolonged exposure to BP was not cytotoxic on its own, a strong enhancement of CD95 (Fa