Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Joen, Luirink"'
Autor:
Dung T. Huynh, Emanuele Nolfi, Lobna Medfai, Peter van Ulsen, Wouter S. P. Jong, Alice J. A. M. Sijts, Joen Luirink
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
ABSTRACTChlamydia trachomatis is an obligate intracellular pathogen responsible for the most prevalent bacterial sexually transmitted disease globally. The high prevalence of chlamydial infections underscores the urgent need for licensed and effectiv
Externí odkaz:
https://doaj.org/article/2716bdd255c7460dada3b26d8b187d92
Autor:
Giuseppe Andreacchio, Ylenia Longo, Sara Moreno Mascaraque, Kartikan Anandasothy, Sarah Tofan, Esma Özün, Lena Wilschrey, Johannes Ptok, Dung T. Huynh, Joen Luirink, Ingo Drexler
Publikováno v:
Vaccines, Vol 12, Iss 8, p 944 (2024)
Chlamydia trachomatis remains a major global health problem with increasing infection rates, requiring innovative vaccine solutions. Modified Vaccinia Virus Ankara (MVA) is a well-established, safe and highly immunogenic vaccine vector, making it a p
Externí odkaz:
https://doaj.org/article/3bda0ec5f9ad422b8e589baa61351000
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTTo infer the biological meaning from transcriptome data, it is useful to focus on genes that are regulated by the same regulator, i.e., regulons. Unfortunately, current gene set enrichment analysis (GSEA) tools do not consider whether a gene
Externí odkaz:
https://doaj.org/article/8d0fe696dd0c42078aee2e187abaf35b
Publikováno v:
Microbial Cell Factories, Vol 20, Iss 1, Pp 1-17 (2021)
Abstract Monomeric autotransporters have been used extensively to transport recombinant proteins or protein domains to the cell surface of Gram-negative bacteria amongst others for antigen display. Genetic fusion of such antigens into autotransporter
Externí odkaz:
https://doaj.org/article/7e4ae359789e4ec7bd0a810c0de8d5cc
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Autotransporters are the core component of a molecular nano-machine that delivers cargo proteins across the outer membrane of Gram-negative bacteria. Part of the type V secretion system, this large family of proteins play a central role in controllin
Externí odkaz:
https://doaj.org/article/84d615eec2714c4daf8378847999870f
Autor:
Lucille F. van Beek, Kristin Surmann, H. Bart van den Berg van Saparoea, Diane Houben, Wouter S. P. Jong, Christian Hentschker, Thomas H. A. Ederveen, Elena Mitsi, Daniela M. Ferreira, Fred van Opzeeland, Christa E. van der Gaast – de Jongh, Irma Joosten, Uwe Völker, Frank Schmidt, Joen Luirink, Dimitri A. Diavatopoulos, Marien I. de Jonge
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 1310-1328 (2020)
Nasopharyngeal colonization by Streptococcus pneumoniae is a prerequisite for pneumococcal transmission and disease. Current vaccines protect only against disease and colonization caused by a limited number of serotypes, consequently allowing serotyp
Externí odkaz:
https://doaj.org/article/3e016418b8e44a38bee691ecfa6505c3
Autor:
Linglei Jiang, Tom A.P. Driedonks, Wouter S.P. Jong, Santosh Dhakal, H. Bart van den Berg van Saparoea, Ioannis Sitaras, Ruifeng Zhou, Christopher Caputo, Kirsten Littlefield, Maggie Lowman, Mengfei Chen, Gabriela Lima, Olesia Gololobova, Barbara Smith, Vasiliki Mahairaki, M. Riley Richardson, Kathleen R. Mulka, Andrew P. Lane, Sabra L. Klein, Andrew Pekosz, Cory Brayton, Joseph L. Mankowski, Joen Luirink, Jason S. Villano, Kenneth W. Witwer
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 3, Pp n/a-n/a (2022)
Abstract Several vaccines have been introduced to combat the coronavirus infectious disease‐2019 (COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Current SARS‐CoV‐2 vaccines include mRNA‐conta
Externí odkaz:
https://doaj.org/article/85e40e2ab5cf4b5994d24e62d93c8c9a
Autor:
Dung T. Huynh, Wouter S. P. Jong, Manon A. H. Oudejans, H. Bart van den Berg van Saparoea, Joen Luirink, Peter van Ulsen
Publikováno v:
Membranes, Vol 13, Iss 4, p 366 (2023)
Chlamydia trachomatis is the bacterial pathogen that causes most cases of sexually transmitted diseases annually. To combat the global spread of asymptomatic infection, development of effective (mucosal) vaccines that offer both systemic and local im
Externí odkaz:
https://doaj.org/article/d75931d18129452291731094b67f4093
Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle.
Autor:
Ruth Steinberg, Andrea Origi, Ana Natriashvili, Pinku Sarmah, Mariya Licheva, Princess M Walker, Claudine Kraft, Stephen High, Joen Luirink, Wei Q Shi, Martin Helmstädter, Maximilian H Ulbrich, Hans-Georg Koch
Publikováno v:
PLoS Biology, Vol 18, Iss 9, p e3000874 (2020)
Small membrane proteins represent a largely unexplored yet abundant class of proteins in pro- and eukaryotes. They essentially consist of a single transmembrane domain and are associated with stress response mechanisms in bacteria. How these proteins
Externí odkaz:
https://doaj.org/article/2e0b61b58b9742239a5084079ef95be7
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Bacterial outer membrane vesicles (OMVs) attract increasing interest as immunostimulatory nanoparticles for the development of vaccines and therapeutic agents. We previously engineered the autotransporter protein Hemoglobin protease (Hbp) into a surf
Externí odkaz:
https://doaj.org/article/dbe401c2eaaf486cb66ee38dac728d9d