Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Joelma Freire De Mesquita"'
Autor:
Loiane Mendonça Abrantes Da Conceição, Lucio Mendes Cabral, Gabriel Rodrigues Coutinho Pereira, Joelma Freire De Mesquita
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5796 (2024)
Friedreich’s Ataxia (FRDA) stands out as the most prevalent form of hereditary ataxias, marked by progressive movement ataxia, loss of vibratory sensitivity, and skeletal deformities, severely affecting daily functioning. To date, the only medicati
Externí odkaz:
https://doaj.org/article/7a966bedf6444a83a1b7d1ced26eabf4
Autor:
Laise Carolina França, Fabrícia Lima Fontes-Dantas, Diogo Gomes Garcia, Amanda Dutra de Araújo, João Paulo da Costa Gonçalves, Cláudia Cecília da Silva Rêgo, Elielson Veloso da Silva, Osvaldo José Moreira do Nascimento, Fernanda Cristina Rueda Lopes, Alice Laschuk Herlinger, Renato Santana de Aguiar, Orlando da Costa Ferreira Junior, Fernando Faria Andrade Figueira, Jorge Paes Barreto Marcondes de Souza, Joelma Freire De Mesquita, Soniza Vieira Alves-Leon
Publikováno v:
Arquivos de Neuro-Psiquiatria, Vol 81, Iss 04, Pp 357-368 (2023)
Background Evidence indicates a strong link between Zika virus (ZikV) and neurological complications. Acute myelitis, optic neuritis, polyneuropathy, and encephalomyelitis that mimic inflammatory idiopathic demyelination disorders (IIDD) after ZikV i
Externí odkaz:
https://doaj.org/article/9c55df440b3c444a949b30eb765e17e3
Autor:
Gabriel Rodrigues Coutinho Pereira, Bárbara de Azevedo Abrahim-Vieira, Joelma Freire de Mesquita
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1095 (2023)
Amyotrophic lateral sclerosis (ALS) is the most prevalent motor neuron disorder in adults, which is associated with a highly disabling condition. To date, ALS remains incurable, and the only drugs approved by the FDA for its treatment confer a limite
Externí odkaz:
https://doaj.org/article/466883845c254e3ea8187d5ffb871368
Autor:
Gabriel Rodrigues Coutinho Pereira, Bárbara de Azevedo Abrahim Vieira, Joelma Freire De Mesquita
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247841 (2021)
Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disorder, with a significant social and economic burden. ALS remains incurable, and the only drugs approved for its treatments confers a survival benefit of a few months for the pa
Externí odkaz:
https://doaj.org/article/acc89258ed00417d93f668124110e8fa
Autor:
Rajaiah Alexpandi, Joelma Freire De Mesquita, Shunmugiah Karutha Pandian, Arumugam Veera Ravi
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The novel coronavirus SARS-CoV-2 disease “COVID-19” emerged in China and rapidly spread to other countries; due to its rapid worldwide spread, the WHO has declared this as a global emergency. As there is no specific treatment prescribed to treat
Externí odkaz:
https://doaj.org/article/da8243bb69ac4f62b617762e465ce1ce
Autor:
Gabriel Rodrigues Coutinho Pereira, Gustavo Duarte Bocayuva Tavares, Marta Costa de Freitas, Joelma Freire De Mesquita
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229730 (2020)
The tryptophan hydroxylase 2 (TPH2) enzyme catalyzes the first step of serotonin biosynthesis. Serotonin is known for its role in several homeostatic systems related to sleep, mood, and food intake. As the reaction catalyzed by TPH2 is the rate-limit
Externí odkaz:
https://doaj.org/article/2461ec8495134ae9866e8e94cb9fdf39
Autor:
Gabriel Rodrigues Coutinho Pereira, Giovanni Henrique Almeida Silva Tellini, Joelma Freire De Mesquita
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0215723 (2019)
Profilin 1 (PFN1) protein plays key roles in neuronal growth and differentiation, membrane trafficking, and regulation of the actin cytoskeleton. Four natural variants of PFN1 were described as related to ALS, the most common adult-onset motor neuron
Externí odkaz:
https://doaj.org/article/dd72cc1b572e4d4785e9b7cb6dc30c80
Autor:
Clara Carolina Silva De Oliveira, Gabriel Rodrigues Coutinho Pereira, Jamile Yvis Santos De Alcantara, Deborah Antunes, Ernesto Raul Caffarena, Joelma Freire De Mesquita
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215508 (2019)
Brain-derived neurotrophic factor (BDNF) plays an important role in neurogenesis and synapse formation. The V66M is the most prevalent BDNF mutation in humans and impairs the function and distribution of BDNF. This mutation is related to several psyc
Externí odkaz:
https://doaj.org/article/e829dd976d5e4c8a8ea2fe633483856c
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158939 (2016)
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that affects the upper and lower motor neurons. 5-10% of cases are genetically inherited, including ALS type 20, which is caused by mutations in the hnRNPA1 gene. The goals of t
Externí odkaz:
https://doaj.org/article/063de119a2a14f3ca5d6b2b62e97d50a
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65558 (2013)
Aging in the world population has increased every year. Superoxide dismutase 2 (Mn-SOD or SOD2) protects against oxidative stress, a main factor influencing cellular longevity. Polymorphisms in SOD2 have been associated with the development of neurod
Externí odkaz:
https://doaj.org/article/43a1f7f086a141128308c2563fd33f53