Výsledky vyhledávání - "Joelle Winckler"

Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome

Autor: Alan T. Nurden, Joelle Winckler, Christelle Lecut, Véronique Arocas, Thomas J. Kunicki, Jean-Max Pasquet, Robert Combrié, Paquita Nurden, Martine Jandrot-Perrus

Publikováno v: Blood. 104:107-114

We report a novel case of gray platelet syndrome (GPS) where a severe deficiency of the platelet collagen receptor, glycoprotein (GP) VI, accompanies classical symptoms of a low platelet count and platelets lacking α-granules. Dense granules were no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c59319481e34d1f79e80f51cf3bfae
https://doi.org/10.1182/blood-2003-11-3842

Zobrazit plný text záznamu

A Ser752→Pro substitution in the cytoplasmic domain of β3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the αIIbβ3 integrin and the platelet granule pool of fibrinogen

Autor: Robert Combrié, Paquita Nurden, Jacques P. Caen, Alan T. Nurden, Christel Poujol, Joelle Winckler

Publikováno v: British Journal of Haematology. 118:1143-1151

Summary. A Glanzmann thrombasthenia variant with a β3 Ser752Pro cytoplasmic domain substitution has platelets that fail to aggregate or bind soluble fibrinogen (Fg) after activation. Despite this, Fg is normally present in the α-granules. We have u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51b90b2002d5dd34719a41c77656902b
https://doi.org/10.1046/j.1365-2141.2002.03758.x

Zobrazit plný text záznamu

Platelet ultrastructural abnormalities in three patients with type 2B von Willebrand disease

Autor: Fabrice Chretien, Christel Poujol, Alan T. Nurden, Joelle Winckler, Paquita Nurden, Annie Borel-Derlon

Publikováno v: British Journal of Haematology. 110:704-714

Several reports have described the presence of giant platelets in patients with type 2B von Willebrand disease (VWD). We have now characterized the ultrastructural changes in platelets from three unrelated patients with type 2B VWD and different muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14c3d535694149b8949f15a2e8ba14b7
https://doi.org/10.1046/j.1365-2141.2000.02246.x

Zobrazit plný text záznamu

Labeling of the Internal Pool of GP IIb-IIIa in Platelets by c7E3 Fab Fragments (abciximab): Flow and Endocytic Mechanisms Contribute to the Transport

Autor: Robert Jordan, Paquita Nurden, Robert Combrié, Claude Bihour, Carrie Wagner, Laurent Macchi, Catherine Durrieu-Jais, Alan T. Nurden, Christel Poujol, Joelle Winckler

Publikováno v: Blood. 93:1622-1633

Abciximab is a new antiplatelet therapeutic in ischemic cardiovascular disease. The drug, chimeric Fab fragments of a murine monoclonal antibody (MoAb) (c7E3), blocks GP IIb-IIIa function. However, its capacity to reach all receptor pools in platelet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1420cd679683f23253046ee826f02d
https://doi.org/10.1182/blood.v93.5.1622.405k03_1622_1633

Zobrazit plný text záznamu

Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane systems of activated human platelets

Autor: Paquita Hourdillé, Kenneth J. Clemetson, Joelle Winckler, Robert Combrié, Alan T. Nurden, Eric Heilmann

Publikováno v: Blood. 76:1503-1513

Previous studies have shown a decreased binding of monoclonal antibodies (MoAbs) to glycoprotein (GP) Ib-IX complexes on thrombin- stimulated platelets, but the reason for this is poorly understood. We have used (1) immunofluorescence procedures and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc401af8a7e7ff5cc44d8534cac384f
https://doi.org/10.1182/blood.v76.8.1503.1503

Zobrazit plný text záznamu

Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system

Autor: Nathalie Pousseau, Paquita Nurden, Sylviane Levy-Toledano, Aida Habib, Robert Combrié, Joelle Winckler, Pamela B. Conley, Christel Poujol, Alan T. Nurden

Publikováno v: Blood. 101(4)

P2Y(1) and thromboxane-prostanoid-alpha (TPalpha) receptors on platelets belong to the G-protein-coupled 7-transmembrane domain family. They transmit signals for shape change, mobilization of calcium, and platelet aggregation. Immunogold labeling wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d32461fe429ce83326f42e08ac8833
https://pubmed.ncbi.nlm.nih.gov/12393588

Zobrazit plný text záznamu

A Ser752--Pro substitution in the cytoplasmic domain of beta3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the alphaIIbbeta3 integrin and the platelet granule pool of fibrinogen

Autor: Paquita, Nurden, Christel, Poujol, Joelle, Winckler, Robert, Combrié, Jacques P, Caen, Alan T, Nurden

Publikováno v: British journal of haematology. 118(4)

A Glanzmann thrombasthenia variant with a beta3 Ser752--Pro cytoplasmic domain substitution has platelets that fail to aggregate or bind soluble fibrinogen (Fg) after activation. Despite this, Fg is normally present in the alpha-granules. We have use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b1005093a97a8d4517149f4b752e3fb
https://pubmed.ncbi.nlm.nih.gov/12199799

Zobrazit plný text záznamu

Ultrastructural studies of platelet aggregates from human subjects receiving clopidogrel and from a patient with an inherited defect of an ADP-dependent pathway of platelet activation

Autor: Eric Heilmann, Paquita Nurden, Joelle Winckler, Thomas J. Kunicki, Jean-Marc Herbert, Pierre Savi, Claude Bihour, Michel Humbert, Jean-Max Pasquet, Alan T. Nurden

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 16(12)

Our study investigated the effect of the antithrombotic drug clopidogrel (75 mg/d for 7 days) on the ultrastructure of platelet aggregates induced by ADP or 2-methylthio-ADP (2-MeS-ADP) in citrated platelet-rich plasma and examined the activation sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e07ceaf5a9776ab8c8d211e93cf8553
https://pubmed.ncbi.nlm.nih.gov/8977459

Zobrazit plný text záznamu

Visualization of activation-dependent epitopes on glycoprotein IIb-IIIa complexes of platelets stimulated by thrombin: immunogold staining of ultrathin sections

Autor: Claude Bihour, Alan T. Nurden, Michel Humbert, Paquita Nurden, Thomas J. Kunicki, Joelle Winckler

Publikováno v: Seminars in thrombosis and hemostasis. 22(3)

An immunoglobulin M monoclonal antibody (IgM MAb; AP-6) recognizing the sequence 211-221 of glycoprotein (GP) IIIa enabled a study of the distribution of this epitope on unstimulated or thrombin-activated platelets. Flow cytometry was used to evaluat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9028f5bfbafb20ba463bcc91c200039
https://pubmed.ncbi.nlm.nih.gov/8836014

Zobrazit plný text záznamu

Confirmation that GP Ib-IX complexes have a reduced surface distribution on platelets activated by thrombin and TRAP-14-mer peptide

Autor: Paquita Nurden, Michel Humbert, Claude Bihour, Joelle Winckler, Robert Combrié, Alan T. Nurden, Eric Cazes, Annie Paponneau

Publikováno v: British journal of haematology. 90(3)

In 1990 we reported that GP Ib-IX complexes accumulated within the surface-connected canalicular system (SCCS) of thrombin-stimulated platelets. This conclusion was reached following investigations using monoclonal antibodies (MAbs) in flow cytometry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d5dce4a06ce7545cd9f8ea05599ddb
https://pubmed.ncbi.nlm.nih.gov/7544151

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání