Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joelle Verhagen"'
Autor:
Robert Elling, Aaron Smith, Matthew Burger, Kay Huh, Hanne Merritt, Sabina Pecchi, Charles Voliva, Jiong Lan, Wooseok Han, Daniel Menezes, John Chan, Teresa E. Williams, Yongjin Xu, Mark Knapp, Joelle Verhagen, Susan Kaufman, Zhi-Jie Ni
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:742-746
Alterations in PI3K/AKT signaling are known to be implicated with tumorigenesis. The PI3 kinases family of lipid kinases has been an attractive therapeutic target for cancer treatment. Imidazopyridine compound 1, a potent, selective, and orally avail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2765997f6c419aa67c3b02c108df4b
https://doi.org/10.1016/j.bmcl.2016.01.003
https://doi.org/10.1016/j.bmcl.2016.01.003
Autor:
Susan Kaufman, Zhang Yanchen, Joshua Haznedar, Daniel Menezes, Matthew Burger, Xiaohua Xin, Aaron Smith, Frazier Kelly, Sauveur-Michel Maira, Allan S. Wagman, Zhi-Jie Ni, Keith B. Pfister, Kay Huh, Isabel Zaror, Thomas Hendrickson, Joelle Verhagen, Gordana Atallah, Kevin Shoemaker, Bartulis Sarah, Michael Chin, Simon Ng, Kenneth Crawford, Dirksen E. Bussiere, Ed Iwanowicz, Mark Knapp, Isabelle Lee, Hanne Merritt, Marion Wiesmann, Charles Voliva, Sabina Pecchi
Publikováno v:
ACS Medicinal Chemistry Letters. 2:774-779
Phosphoinositide-3-kinases (PI3Ks) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. Herein we describe the structure guided optimization of a series of 2-morpholino, 4-substituted, 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31ec0f7f889d4d0d8c5baf0ae8c19fd
https://doi.org/10.1021/ml200156t
https://doi.org/10.1021/ml200156t
Autor:
Sharadha Subramanian, Song Lin, Abran Costales, Hashash Ahmad, Mina Aikawa, Leonard Sung, Johanna M. Jansen, Savithri Ramurthy, Cynthia M. Shafer, Paul A. Renhowe, Joelle Verhagen, Payman Amiri, Sylvia Ma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3286-3289
Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan-Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547fbcd3db3efa6a58bf107e5a7a92d3
https://doi.org/10.1016/j.bmcl.2011.04.023
https://doi.org/10.1016/j.bmcl.2011.04.023
Autor:
Brain Gallagher, Joelle Verhagen, Frank E. Cappuccio, Praveen Thoniyot, Bakthan Singaram, Cian Christopher Watts
Publikováno v:
Tetrahedron: Asymmetry. 17:1301-1307
Catalytic asymmetric transfer hydrogenations of aromatic alkyl ketones have been studied using [RuCl2(p-cymeme)]2 and terpene-based β-amino alcohols. The limonene derived amino alcohol, (1S,2S,4R)-1-methyl-4-(1-methylethenyl)-2-(methylamino)cyclohex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b80b306598bb5ba513ef91c87877694
https://doi.org/10.1016/j.tetasy.2006.04.025
https://doi.org/10.1016/j.tetasy.2006.04.025
Autor:
Joelle Verhagen, Brent A. Appleton, Cynthia M. Shafer, Sharadha Subramanian, Louie Alicia, Abran Costales, William R. Antonios-Mccrea, Kimberly Aardalen, Maureen Mckenna, Darrin Stuart, Paul A. Renhowe, Leonard Sung, Barry Levine, Teresa E. Williams, Timothy D. Machajewski, Savithri Ramurthy, James Chou, Daniel Poon, Christopher McBride, Payman Amiri
Publikováno v:
ACS medicinal chemistry letters. 6(9)
Abrogation of errant signaling along the MAPK pathway through the inhibition of B-RAF kinase is a validated approach for the treatment of pathway-dependent cancers. We report the development of imidazo-benzimidazoles as potent B-RAF inhibitors. Robus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ee4145fd74f752a18851401d18ecca
https://pubmed.ncbi.nlm.nih.gov/26396681
https://pubmed.ncbi.nlm.nih.gov/26396681
Autor:
Darrin Stuart, Teresa E. Williams, Daniel Poon, Savithri Ramurthy, Payman Amiri, Sharadha Subramanian, Cynthia M. Shafer, Abran Costales, Barry Levine, Joelle Verhagen, Paul A. Renhowe, Christopher McBride
Publikováno v:
ACS medicinal chemistry letters. 5(9)
Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure–activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631da30643ffa236aa0d6a9d30aec126
https://pubmed.ncbi.nlm.nih.gov/25514817
https://pubmed.ncbi.nlm.nih.gov/25514817
Autor:
Mark Knapp, Marion Weismann, Xiaohua Xin, Zhang Yanchen, Ed Iwanowicz, Allan S. Wagman, Charles Voliva, Sabina Pecchi, Frazier Kelly, Matthew Burger, Hanne Merrit, Joelle Verhagen, Zhi-Jie Ni, Keith B. Pfister, Thomas Hendrickson, Bartulis Sarah, Simon Ng, Joshua Haznedar, Aaron Smith, Gordana Atallah
Publikováno v:
ACS medicinal chemistry letters. 2(1)
Phospoinositide-3-kinases (PI3K) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. A series of 2-morpholino, 4-substituted, 6-(3-hydroxyphenyl) pyrimidines have been reported as poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ea9cc9b672683ff665364e7bedd0c8
https://pubmed.ncbi.nlm.nih.gov/24900252
https://pubmed.ncbi.nlm.nih.gov/24900252
Autor:
Joelle Verhagen, Teresa E. Williams, Payman Amiri, Paul A. Renhowe, Daniel Poon, Darrin Stuart, Christopher McBride, Sharadha Subramanian, Abran Costales, Barry Levine, Savithri Ramurthy, Cynthia M. Shafer
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1340-1340
The error is on page 990 in Table 1. Compound 11 should be 3-OCF3, and compound 16 should be 4-OCF3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::822b070033880f5ece9cf976f0dcbaba
https://doi.org/10.1021/ml500461g
https://doi.org/10.1021/ml500461g