Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joelle S. Suarez"'
Autor:
Angela Bononi, Qian Wang, Alicia A. Zolondick, Fang Bai, Mika Steele-Tanji, Joelle S. Suarez, Sandra Pastorino, Abigail Sipes, Valentina Signorato, Angelica Ferro, Flavia Novelli, Jin-Hee Kim, Michael Minaai, Yasutaka Takinishi, Laura Pellegrini, Andrea Napolitano, Ronghui Xu, Christine Farrar, Chandra Goparaju, Cristian Bassi, Massimo Negrini, Ian Pagano, Greg Sakamoto, Giovanni Gaudino, Harvey I. Pass, José N. Onuchic, Haining Yang, Michele Carbone
Publikováno v:
Proceedings of the National Academy of Sciences. 120
BAP1 is a powerful tumor suppressor gene characterized by haplo insufficiency. Individuals carrying germline BAP1 mutations often develop mesothelioma, an aggressive malignancy of the serosal layers covering the lungs, pericardium, and abdominal cavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdacf9010fd92242e88435de9b6c23d0
https://doi.org/10.1073/pnas.2217840120
https://doi.org/10.1073/pnas.2217840120
Autor:
Flavia Novelli, Michele Carbone, Giovanni Gaudino, Ian Pagano, Muzaffer Metintas, Sandra Pastorino, Betsy Morrow, Haining Yang, Mitsuru Emi, Masaki Nasu, Guntulu Ak, Joelle S. Suarez, Lorenzo Carparelli, Keisuke Goto, Yoshie Yoshikawa, Raffit Hassan, Michael Minaai, Yasutaka Takinishi, Joseph J. Grzymski, Ronghui Xu, Muhittin Akarsu, Mika Tanji, Jin-Hee Kim, Joanna L. Groden, Harvey I. Pass, Angela Bononi, Angelica Ferro
Publikováno v:
Proceedings of the National Academy of Sciences. 117:33466-33473
Rare biallelic BLM gene mutations cause Bloom syndrome. Whether BLM heterozygous germline mutations (BLM+/−) cause human cancer remains unclear. We sequenced the germline DNA of 155 mesothelioma patients (33 familial and 122 sporadic). We found 2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c94399d49d844b0391611cb8e9cff83d
https://doi.org/10.1073/pnas.2019652117
https://doi.org/10.1073/pnas.2019652117
Autor:
Michael Minaai, Giovanni Gaudino, Michele Carbone, Joelle S. Suarez, Haining Yang, Harvey I. Pass, Jiaming Xue, Shuangjing Li
Publikováno v:
J Cell Physiol
High-mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 has since been reevaluated to be a prototypical damage-associated m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e103bae06dc8fe7ff9ab6448b7187adf
https://doi.org/10.1002/jcp.30125
https://doi.org/10.1002/jcp.30125
Autor:
Keisuke Goto, Simone Patergnani, Mauro Tognon, Carlotta Giorgi, Ronghui Xu, Flavia Novelli, Harvey I. Pass, Angela Bononi, Sandra Pastorino, Mika Tanji, Giovanni Gaudino, Michele Carbone, Jiaming Xue, Natascia Caroccia, A. Umran Dogan, Haining Yang, Joelle S. Suarez, Paolo Pinton, Tak W. Mak
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Asbestos causes malignant transformation of primary human mesothelial cells (HM), leading to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as exposure to asbestos induces HM death. However, some asbestos-exposed HM escape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bc915d4b6620563ad085ccc6821338
https://doi.org/10.1073/pnas.2007622117
https://doi.org/10.1073/pnas.2007622117
BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos
Autor:
Yasutaka Takanishi, Giovanni Gaudino, Ellinor Haglund, Michael Minaai, Haithem Barbour, Mika Tanji, Fang Bai, Qian Wang, Simone Patergnani, Sandra Pastorino, Michele Carbone, Angela Bononi, Harvey I. Pass, Paul Morris, Carlotta Giorgi, Joelle S. Suarez, Franz Kricek, Haining Yang, Paolo Pinton, Ronghui Xu, José N. Onuchic, Greg Sakamoto, Flavia Novelli
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Significance Our findings explain mechanistically the observed gene × environment (G×E) interaction in mesotheliomas occurring in carriers of heterozygous germline BAP1 mutations ( BAP1 +/− ) exposed to asbestos. The increased amount of acetylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc71c41a53a8055d8011694b12d1ec9
Autor:
Angela, Bononi, Keisuke, Goto, Guntulu, Ak, Yoshie, Yoshikawa, Mitsuru, Emi, Sandra, Pastorino, Lorenzo, Carparelli, Angelica, Ferro, Masaki, Nasu, Jin-Hee, Kim, Joelle S, Suarez, Ronghui, Xu, Mika, Tanji, Yasutaka, Takinishi, Michael, Minaai, Flavia, Novelli, Ian, Pagano, Giovanni, Gaudino, Harvey I, Pass, Joanna, Groden, Joseph J, Grzymski, Muzaffer, Metintas, Muhittin, Akarsu, Betsy, Morrow, Raffit, Hassan, Haining, Yang, Michele, Carbone
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We found that the probability of carrying heterozygous germline BLM mutations is significantly higher among mesothelioma patients than in the general population. In vitro and in vivo experiments suggest that heterozygous BLM mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17f6184e0ad9558e02d2cc8ccba8ba28
https://pubmed.ncbi.nlm.nih.gov/33318203
https://pubmed.ncbi.nlm.nih.gov/33318203