Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joelle Ngo Hanna"'
Autor:
Rita Ayuk Ndip, Joelle Ngo Hanna, James Ajeck Mbah, Stephen Mbigha Ghogomu, Moses Njutain Ngemenya
Publikováno v:
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2023 (2023)
The global burden of Salmonella infections remains high due to the emergence of multidrug resistance to all recommended treatment antibiotics. Tetrahydroisoquinolines (THIQs) have demonstrated promising activity against multidrug-resistant (MDR) Salm
Externí odkaz:
https://doaj.org/article/c3cee897d46d49c4845719f6077534fc
Autor:
Joelle Ngo Hanna, Rita A. Ndip, Moses N. Ngemenya, Casey R. Simons, Flavien A. A. Toze, Stephen M. Ghogomu, James A. Mbah
Publikováno v:
Scientific African, Vol 17, Iss , Pp e01302- (2022)
The high burden of Salmonella infections has been aggravated by the emergence and spread of multidrug-resistant strains affecting almost all antibiotic classes recommended for treatment. Several tetrahydroisoquinolines, both natural and synthetic, ar
Externí odkaz:
https://doaj.org/article/3f5e385d9df348da91213c9273e6e0fa
Autor:
Joelle Ngo Hanna, Vincent de Paul N. Nziko, Fidele Ntie-Kang, James A. Mbah, Flavien A.A. Toze
Publikováno v:
Heliyon, Vol 7, Iss 5, Pp e07032- (2021)
A quantitative structure-activity relationship (QSAR) study was conducted using nineteen previously synthesized, and tested 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines with proven in vitro activities against Plasmodium falciparum. In order to co
Externí odkaz:
https://doaj.org/article/e6d5cc0ce3a74a33aca3c97b605c66cb
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 6, Pp 472-477 (2015)
Objective: To evaluate the antibacterial activity of ten synthetic tetrahydroisoquinolines against eight bacterial strains. Methods: The ten tetrahydroisoquinolines synthesized via base-catalyzed Pictet–Spengler cyclization were screened against a
Externí odkaz:
https://doaj.org/article/3e91e985532f41bd901945aceca51097
Autor:
Joelle Ngo Hanna, A. Rita Ndip, Moses N. Ngemenya, Casey R. Simons, Flavien A. A. Toze, Fidele Ntie-Kang, Stephen M. Ghogomu, James Ajeck Mbah
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90008dd55cd713164134a802695ccb29
https://doi.org/10.2139/ssrn.4094947
https://doi.org/10.2139/ssrn.4094947
Autor:
Luc C. Owono Owono, Flavien A. A. Toze, James A. Mbah, Boris D. Bekono, Joelle Ngo Hanna, Fidele Ntie-Kang, Stefan Günther
Publikováno v:
Physical Sciences Reviews.
In the quest to know why natural products (NPs) have often been considered as privileged scaffolds for drug discovery purposes, many investigations into the differences between NPs and synthetic compounds have been carried out. Several attempts to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eea652f68895471b06a87587686699a
https://doi.org/10.1515/psr-2019-0096
https://doi.org/10.1515/psr-2019-0096
Publikováno v:
RSC Adv.. 4:22856-22865
In the present study, twenty-one 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline (THIQ) analogues were synthesized by base-catalyzed Pictet–Spengler reaction, and tested in vitro against P. falciparum using the [3H]hypoxanthine incorporation assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22dec258628c884110979d150109f4ac
https://doi.org/10.1039/c3ra46791k
https://doi.org/10.1039/c3ra46791k
Publikováno v:
ChemInform. 46
3-Hydroxyphenethylamine derived from substrate (I) undergoes Pictet—Spengler reaction with a wide variety of aldehydes and cyclohexanone to form the title compounds (III) and (V).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b929d67826b4a226f966cfdad5a12f13
https://doi.org/10.1002/chin.201502149
https://doi.org/10.1002/chin.201502149
Autor:
Simon M. N. Efange, Eugene Megnassan, Joelle Ngo Hanna, Lydia L. Lifongo, Luc C Owono Owono, Pascal Amoa Onguéné, Wolfgang Sippl, Michael Scharfe, James A. Mbah, Fidele Ntie-Kang, Fidelis Cho-Ngwa, Luc Meva'a Mbaze
Publikováno v:
BMC Complementary and Alternative Medicine
Background Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery protocols. We present CamMedNP - a new database beginning with more than 2,500 comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e76aff7e6fdeeca15deb108f8c9aa08
https://pubmed.ncbi.nlm.nih.gov/23590173
https://pubmed.ncbi.nlm.nih.gov/23590173