Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Joelle N Pelletier"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210100 (2019)
Through the application of a region-focused saturation mutagenesis and randomization approach, protein engineering of the Cal-A enzyme was undertaken with the goal of conferring new triglyceride selectivity. Little is known about the mode of triglyce
Externí odkaz:
https://doaj.org/article/914f45d074ee4c0ca8535fb250c30289
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171741 (2017)
The Golden Gate strategy entails the use of type IIS restriction enzymes, which cut outside of their recognition sequence. It enables unrestricted design of unique DNA fragments that can be readily and seamlessly recombined. Successfully employed in
Externí odkaz:
https://doaj.org/article/22ccb32669e245bfbd118bd9a69d8e5b
Autor:
Christopher M Clouthier, Sébastien Morin, Sophie M C Gobeil, Nicolas Doucet, Jonathan Blanchet, Elisabeth Nguyen, Stéphane M Gagné, Joelle N Pelletier
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52283 (2012)
Enzyme engineering has been facilitated by recombination of close homologues, followed by functional screening. In one such effort, chimeras of two class-A β-lactamases - TEM-1 and PSE-4 - were created according to structure-guided protein recombina
Externí odkaz:
https://doaj.org/article/ca632b9d42fd4332a332b46c4fd95d68
Autor:
Henintsoa Rabezanahary, Caroline Gilbert, Kim Santerre, Martina Scarrone, Megan Gilbert, Mathieu Thériault, Nicholas Brousseau, Jean-François Masson, Joelle N. Pelletier, Denis Boudreau, Sylvie Trottier, Mariana Baz
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e31026- (2024)
Background: Measuring the ability of SARS-CoV-2 antibodies to neutralize live viruses remains an effective approach to quantify the level of protection of individuals. We assessed the neutralization activity against the ancestral SARS-CoV-2, Delta, O
Externí odkaz:
https://doaj.org/article/43df00f6abec42b690d0fb275a928c15
Autor:
Malama Chisanga, Hannah Williams, Denis Boudreau, Joelle N. Pelletier, Sylvie Trottier, Jean-Francois Masson
Publikováno v:
Analytical Chemistry. 95:3638-3646
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d617d14436efa24d8874c18a85da95ea
https://doi.org/10.1021/acs.analchem.2c04514
https://doi.org/10.1021/acs.analchem.2c04514
Publikováno v:
Biochemistry. 62:396-409
Engineering studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726c72ac6627f5cba5c4c5855db3367d
https://doi.org/10.1021/acs.biochem.2c00513
https://doi.org/10.1021/acs.biochem.2c00513
Autor:
Adem Hadjabdelhafid-Parisien, Sebastian Bitsch, Arturo Macarrón Palacios, Lukas Deweid, Harald Kolmar, Joelle N. Pelletier
Publikováno v:
RSC Advances. 12:33510-33515
We present an efficient approach for tag-free, site-specific conjugation of a fully glycosylated antibody using microbial transglutaminase (mTG). We created variants of trastuzumab where a single surface-exposed residue of the human crystallizable fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ac72cddf9497062599eadfdfa35f61
https://doi.org/10.1039/d2ra05630e
https://doi.org/10.1039/d2ra05630e
Autor:
Malama Chisanga, Matthew Stuible, Christian Gervais, Denis L'Abbé, Brian Cass, Louis Bisson, Alex Pelletier, Simon Lord-Dufour, Yves Durocher, Denis Boudreau, Sylvie Trottier, Joelle N. Pelletier, Jean-Francois Masson
Publikováno v:
Sensors & Diagnostics. 1:851-866
Monitoring antibody response to SARS-CoV-2 is critical for assessing the humoral response, especially important considering the emergence of multiple SARS-CoV-2 variants of concern (VOCs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58a7daf80b876ccc7cb27ceef3792316
https://doi.org/10.1039/d2sd00073c
https://doi.org/10.1039/d2sd00073c
Autor:
Abdelhadi Djaïleb, Étienne Lavallée, Megan-Faye Parker, Marie-Pierre Cayer, Florence Desautels, Marie Joëlle de Grandmont, Matthew Stuible, Christian Gervais, Yves Durocher, Sylvie Trottier, Denis Boudreau, Jean-Francois Masson, Danny Brouard, Joelle N. Pelletier
Publikováno v:
Frontiers in Immunology. 13
IntroductionEarly in the COVID-19 pandemic, reagent availability was not uniform, and infrastructure had to be urgently adapted to undertake COVID-19 surveillance.MethodsBefore the validation of centralized testing, two enzyme-linked immunosorbent as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a398961b6e949ad61c55d77bc875e8b8
https://doi.org/10.3389/fimmu.2022.1052424
https://doi.org/10.3389/fimmu.2022.1052424
Autor:
Claudèle Lemay-St-Denis, Lorea Alejaldre, Zakaria Jemouai, Kiana Lafontaine, Maxime St-Aubin, Katia Hitache, Donya Valikhani, Nuwani W. Weerasinghe, Myriam Létourneau, Christopher J. Thibodeaux, Nicolas Doucet, Christian Baron, Janine N. Copp, Joelle N. Pelletier
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
We present a potential mechanism for emergence of catalytic activity that is essential for survival, from a non-catalytic protein fold. The type B dihydrofolate reductase (DfrB) family of enzymes were first identified in pathogenic bacteria because t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e4eea807c3f710be1ab55aacf4e9604
https://doi.org/10.1098/rstb.2022.0040
https://doi.org/10.1098/rstb.2022.0040