Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1

Autor: Joelle Kersual, Thomas Kirkegaard-Sørensen, Julie Vandekerckhove, Yael Zermati, Bruno Varet, Carmen Garrido, Michael Dussiot, Ann Zeuner, Jean-Antoine Ribeil, Séverine Coulon, Séverine Cathelin, Eric Solary, Ivan C. Moura, Olivier Hermine

Publikováno v: Nature. 445:102-105

Caspase-3 is activated during both terminal differentiation and erythropoietin-starvation-induced apoptosis of human erythroid precursors. The transcription factor GATA-1, which performs an essential function in erythroid differentiation by positivel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f64890889b5cdaf7f958b12a81bed82
https://doi.org/10.1038/nature05378

Human T-cell lymphotropic virus oncoprotein Tax represses TGF-β1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis

Autor: Pierre Charneau, Alain Mauviel, Bertrand Arnulf, Ali Bazarbachi, Aude Villemain, Elodie Mordelet, Olivier Hermine, Christophe Nicot, Yael Zermati, Joelle Kersual

Publikováno v: Blood. 100:4129-4138

Human T-cell leukemia virus I is the etiologic agent of adult T-cell leukemia (ATL), an aggressive T-cell malignancy. The viral oncoprotein Tax, through the activation of nuclear factorkappaB (NF-kappaB), CCAAT-enhancer binding protein (CREB), and ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7ab9dcdb5e250e660eb728f2eaaeb0
https://doi.org/10.1182/blood-2001-12-0372

Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms

Autor: Frédéric Féger, Sebastion Létard, Joelle Kersual, Michel Dy, Yael Zermati, Olivier Lortholary, Nathalie Casteran, Michel Arock, Olivier Hermine, Yann Bieche, Karim Dorgham, Paulo De Sepulveda, Patrice Dubreuil, Michel Vidaud, Antoni Ribadeau Dumas, Guy Gorochov, Christophe Parizot

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2003, 22 (5), pp.660-4. ⟨10.1038/sj.onc.1206120⟩
Oncogene, Nature Publishing Group, 2003, 22 (5), pp.660-4. 〈10.1038/sj.onc.1206120〉
Oncogene, 2003, 22 (5), pp.660-4. ⟨10.1038/sj.onc.1206120⟩

Systemic mastocytosis (SM) is a rare disease caused by an abnormal mast cell accumulation in various tissues. Two classes of constitutive activating c-kit mutations are found in SM. The most frequent class occurs in the catalytic pocket coding region

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d49a5446c1b1ac4973b1867df5a5ad
https://hal.archives-ouvertes.fr/hal-00282566

Caspase Activated Rock-1 Allows Erythroblasts Enucleation Independently of Cytokine Signaling

Autor: Julie Vandekerckhove, Joelle Kersual, Yunhua Chang, Geneviève Courtois, William Vainchenker, Olivier Hermine, Bruno Varet, Jean-Antoine Ribeil, Najet Debili

Publikováno v: Blood. 112:2885-2885

Stem Cell Factor (SCF) and Erythopoietin (Epo) are strictly required for preventing apoptosis and stimulating proliferation, allowing differentiation of erythroid precursors from CFU-E until the polychromatophilic stage. In contrast, terminal maturat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6349119486f1a04573155c2020fdde86
https://doi.org/10.1182/blood.v112.11.2885.2885

Methylthioadenosine toxicity and metabolism to methionine in mammalian cells

Autor: Jean-Louis Pérignon, Joelle Kersual, Laurence Christa, Joelle Augé

Publikováno v: Biochemical Journal. 255:145-152

5′-Deoxy-5′-methylthioadenosine, a by-product of polyamine synthesis, can support the growth of Raji cells in a methionine-free medium, but not the growth of CCL39 cells, although these cells are also able to incorporate radiolabelled 5′-deoxy-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9a530d4a00e6fef32fb73945e80b92
https://doi.org/10.1042/bj2550145